Protease Enzyme Therapy for Cancer and Papaya Leaf

Scientists continue to work to define the reason why proteases like the ones in papaya leaf (papain and chymopapain) have shown to slow the growth of tumors.

“…we have discovered that proenzyme therapy, mandated first by John Beard nearly one hundred years ago, shows remarkable selective effects that result in growth inhibition of tumor cells with metastatic potential.”

-Proenzyme therapy of cancer. Novak JF, et al. Anticancer Res. 2005 Mar-Apr.

John Beard, a Scottish doctor, proved the effect of trypsin (a protease taken from a young cow) on halting the growth of tumors in humans by injecting part of the Pancreas of the young cow straight into human tumors.

Papain has been shown to be more powerful of a protease than trypsin.

56% of Breast Cancer Cells Inhibited by Papaya Leaf

Vietnamese researchers claim that 56% of breast cancer cells were inhibited by papaya leaf in the lab. The scientists also made note that the papaya leaf was harmless to the healthy cells. The control used was vitamin C, and papaya leaf showed a much higher antioxidant level with equal dosage.

Their research included tests on lung cancer (62% cells inhibited), and leukemia (60% cells inhibited).

-Research on Biological Activity of some Extracts from Vietnamese Carica papaya Leaves
Do Thi Hoa Vien, Phung Thi Thuy

ASEAN Journal of Chemical Engineering, vol. 12 no.2 (2012)

In with the Old (Protease Therapy for Cancer); On with the NEW (Papain in Papaya Leaf as the Protease)

Proponent of Protease Enzyme Therapy for Cancer, Dr. Gonzales, carefully reviewed prior clinical studies performed by Dr. Kelley at Cornell University and the treatments were shown to have effect.
“Historically, large doses of proteolytic enzymes, along with diet, nutritional supplements, and “detoxification” procedures, have been used in alternative therapies to treat all forms of cancer, without formal clinical studies to support their use. A 2-year, unblinded, 1-treatment arm, 10-patient, pilot prospective case study was used to assess survival in patients suffering inoperable stage II-IV pancreatic adenocarcinoma treated with large doses of orally ingested pancreatic enzymes, nutritional supplements, “detoxification” procedures, and an organic diet. From January 1993 to April 1996 in the authors’ private practice, 10 patients with inoperable, biopsy-proven pancreatic adenocarcinoma were entered into the trial. After one patient dropped out, an 11th patient was added to the study (however, all 11 are considered in the data tabulation). Patients followed the treatment at home, under the supervision of the authors. As of 12 January 1999, of 11 patients entered into the study, 9 (81%) survived one year, 5 (45%) survived two years, and at this time, 4 have survived three years. Two patients are alive and doing well: one at three years and the other at four years. These results are far above the 25% survival at one year and 10% survival at two years for all stages of pancreatic adenocarcinoma reported in the National Cancer Data Base from 1995. This pilot study suggests that an aggressive nutritional therapy with large doses of pancreatic enzymes led to significantly increased survival over what would normally be expected for patients with inoperable pancreatic 6|Page adenocarcinoma.”

-“Evaluation of Pancreatic Proteolytic Enzyme Treatment of Adenocarcinoma of the Pancreas, With Nutrition and Detoxification Support”
Nicholas Gonzales and Linda Lee Isaacs
Nutrition and Cancer, volume 33 -Issue 2 March 1999 , pages 117 – 124

Protease Enzymes for Cancer Doctor/ Scientists 2005 and prior:

Beard, Dr. John
Howell, Dr. Edward
Wolf, Dr. Max
Benitez, Helen
Ranzberger, Dr. Karl
Kelley, Dr. William Donald
Gonzales, Dr. Nicholas
Isaacs, Dr. Linda
Good, Dr. Robert
Nieper, Dr. Hans
Murray, Dr.
Trnka, Dr. Frantisek
Novak, Dr. Josef F.

Translate Us To Your Country


The Director of The Julia Ruffin Project, Jill Nicole Gallo, needs a volunteer from each country to help translate information on our website to other languages.

The site

is our most important engine to promote the effect of papaya leaf tea on cancer. We need this healing information to be known around the world.

If you are willing to translate for us we will give you credit on our website and you will give people in your country information that could bring healing to their body and to their families. Please send a comment on this blog with your name, country, and language if you can volunteer for this very important service. We will respond back to you and ask you to go forward if the language has not already been claimed.

Thank you in advance for your help, and we very much appreciate if you have an ability to donate to the Julia Ruffin Project.

Papain Pill or Papaya Leaf Tea

After the first stages of my research on papaya leaf tea I contacted an oncologist to review my study with. I asked him why the papain pills on the shelf all over the world are not just as good a choice as the papaya leaf tea. He told me that earlier in their research with one if the large cancer foundations his team was isolating b12. He said that they put so much b12 in a man that it almost killed him. From this experience he said that he learned how God or nature works naturally we can’t always find scientific reasoning behind. This didn’t stop me from trying to pursue the answer to why the leaf tea is different from papain plain. So far the reason is the co-enzymes that work with, in conjunction with papain.

See more in the e-book. papayaleavesforcancer

Papaya Leaf Tea has Effect Against Cancer

Papaya leaf tea is used as alternative cancer therapy in fourteen countries. I have studied the science and the farming of the herb for six years. It seems odd that the large papaya fruit-bearing tree is actually classified as an herb. It seems equally odd that the young leaves of this tree make such a miraculous medicinal tea.

Scientists that have studied the anti-tumor effect of the leaves find various medical reasons that the tea has effect against cancer. One of the most well known is research by Nam Dang. I choose to stick by my favorite; that the tea has an unusual enzyme to nature called papain that breaks down and dissolves proteins. Another form of “protease” is called trypsin, and is naturally produced by our pancreas. The protease dissolves the fibrin, or protein coating around our cancer cells or running in our blood thus freeing our bodies to fight or prevent the cancer.

The leaves need to be initially heated to 150-160F degrees to activate the enzyme, therefore, a “tea”.