Pill with Papaya Leaf Extract Intended to Fight Dengue

There are a number of positive results from various clinical studies on the effect of papaya leaf juice on Dengue Fever:

1. https://clinicaltrials.gov/ct2/show/NCT02016027

2. http://ijabmr.org/article.asp?issn=2229-516X;year=2016;volume=6;issue=4;spage=249;epage=254;aulast=Charan

3. http://www.openaccessscience.com/pdf-files/vol2_4_dec2012/IJMAP_2_4_4_Carica_papaya.pdf

4. http://slctr.lk/trials/110%20%

5. http://www.jcbsonline.ac.in/Articles/12.%20Case%20report%201%20final%20print.pdf

6. Review of seven clinical studies


7. https://www.worldwidejournals.com/indian-journal-of-applied-research-(IJAR)/file.php?val=October_2016_1477141322__191.pdf

And now a clinical study on Microlab’s nutraceutical pill, Caripill:




The Julia Ruffin Project promotes papaya leaf for its effect on disease.

Papaya Leaf Has The Caffeic Acid That Battles Prostate and Breast Cancer

Of the list of cancer-fighting phytochemicals found in papaya leaf, Caffeic Acid has been shown as the most abundant of any in the papaya leaf, and significantly more abundant in the leaf than in any other part of the papaya plant including the fruit.

-Proximate Analysis, Antioxidant and Anti Proliferative Activities of Different Parts of Carica papaya Maisarah AM1, Asmah R1 and Fauziah O2, 1Department of Nutrition and Dietetics, Universiti Putra Malaysia, Malaysia 2Department of Human Anatomy, Universiti Putra Malaysia, Malaysia


What is significant about this is that Caffeic acid has shown effect on fighting specifically Prostate and Breast cancer. Its use is also as a complement to standard drugs like Tamoxifen. See the selected studies below.

Prostate Cancer:




Breast Cancer:





2016 Study on Fermented Papaya in form of FPP Indicates Cancer Effect

FPP is a registered trademark for a natural preparation of fermented green papaya that has been under intense study for years related to its effect on cancer and viruses.

The study below, published this year by the Asian Pacific Journal of Cancer Prevention, discusses the amazing effect of fermented papaya taken orally, on tumors.

The fermenting of papaya leaf is part of the ancient Aryuvetic medicine. The papaya leaf has some similar enzymes that may account for the medicinal-related properties also found in the green, unripe papaya used as the base for FPP. Fermented products have shown to be more easily absorbed by the body.

Anti-Tumor and Immunoregulatory Effects of Fermented Papaya Preparation (FPP: SAIDO-PS501)

Shinki Murakami1*, Shingo Eikawa2, Savas Kaya2, Mitsuko Imao1, Toshiki Aji2

 Asian Pac J Cancer Prev, 17 (7), 3077-3084

Scientists published papaya leaf tea as invention to combat cancer

Filed in 2005 by Nam Dang and Chikao Morimoto to the US Patent Office, the portion of the application below offers a view from the scientists as to the way to brew and take the tea for effect on more than ten types of cancer. 

The indication from the application looks like it is “preferable” to take one half to three cups per day of papaya leaf tea, approximately, for one to three months to combat the listed cancers.

…”The present invention’s brew/extract components, prepared from, for example, a papaya leaf, or fractionated components thereof, are effective in the prevention or treatment of stomach cancer, lung cancer, pancreatic cancer, liver cancer, colon cancer, uterine cancer, ovarian cancer, neuroblastoma or other solid cancers, or lymphoma, leukemia or other blood cancers. In a preferred embodiment, treatment is administered to those suffering from a disease. In another embodiment, treatment is administered as prophylaxis. The dose of the brew/extract components or fractionated components thereof to be administered will depend on the dosage form, symptoms of the subject, type of cancer or the like. However, for example, when the brew/extract is taken, it is normally preferable to take an amount of 100 ml to 750 ml per day, every day for between one month and three months. When the fractionated components are taken, it is preferable to take an amount of 10 ml to 200 ml per day, every day for between one month and three months.”

Section [0011]

Compositions for Cancer Prevention, Treatment, or Amelioration Comprising Papaya Extract 

US 20080069907 A1

The scientists, along with Noriko Otsuki, also published in the Journal of Ethnopharmocology the following study in 2010, “Aqueous extract of Carica papaya leaves exhibits anti-tumor activity and immunomodulatory effects” which revealed in detail their science behind the tea.

This article is not intended to prescribe the tea, only to publish information related that is available by academics who study papaya leaf.

Papaya Leaf for the Natural and Affordable War on TB

A recent article in Aljazeera documents the desperate poverty, a shortage of funding for TB medication, and developing resistance to TB drugs in Madagascar.

Madagascar: The vulnerability to tuberculosis http://aje.io/tdy7

New research in India has shown the potential of papaya leaf for its effect on TB.

“…By using alamar blue dye assay and in-vitro bioassay based on inactivation of viability by a procedure similar to neutralization test were used to study the inhibition of Mycobacterium tuberculosis which shows anti-tb activity against clinical strains of sensitive and drug resistant Mycobacterium tuberculosis (pyrazinamide, streptomycin, ciprofloxacin). The present results are possibly one of the first few investigations showing a clear indication of the potent anti-tubercular effect of carica papaya.”

Naga Swathi Sree Kavuri, Sravani Yangalasetti, Venkata Rao Vutla. Anti-tubercular Activity of Leaf and Seed Extract of Carica papaya. Inventi Rapid: Planta Activa, 2016(1): 1-3, 2015

Papaya Leaf Listed for AntiDiabetic Potential in Cuba

Papaya Leaf was one among a list of seventeen herbal candidates for potential diabetes treatment in Cuba.

“Carica papaya L. (C. papaya)
Traditional use to treat diabetes in: USA 17, Trinidad and Tobago44, Mexico47, Nigeria 48. India49 Hypoglycemic potential of C. papaya leaf aqueous extract was demonstrated by lowering of fasting blood glucose levels in rats with Streptozotocin – and Aloxan.- induced diabetes that were orally treated with this product 50, 51.”

Antidiabetic potential of plants used in Cuba
García Mesa, M.
National Institute of Angiology and Vascular Surgery, 1551 Calzada del Cerro, 12000 Cerro, Havana, Cuba

Pharmacology Online
Archives • 2014 • vol.1 •52-62
April 30, 2014


What Type of Cancer Has Papaya Leaf Shown to Affect?

Sheikh Fauziya in his paper, “Papaya: Source for Anticancer”, created a summary of the types of cancer lines studied so far that papaya leaf has shown to affect:

Stomach Cancer
Pancreatic Cancer
Colon Cancer
Ovarian Cancer
Lymphoma Cancer
Breast Cancer
Neuroblastoma Cancer
Uterine Cancer
Leukemia Cancer
Cervical Cancer
Hepatocellular Cancer

-CIBTech Journal of Pharmaceutical Sciences ISSN: 2319–3891 (Online)
An Online International Journal Available at http://www.cibtech.org/cjps.htm 2013 Vol.2 (1) January-March, pp.25-34/Sheikh and Krishnamurthy
Review Article
*Sheikh Fauziya and R Krishnamurthy
CG Bhakta Institute of Biotechnology, Uka Tarsadia University, Maliba Campus Bardoli, Dist. Surat, Gujarat, India-394350
*Author for Correspondence