Protease Enzyme Therapy for Cancer and Papaya Leaf

Scientists continue to work to define the reason why proteases like the ones in papaya leaf (papain and chymopapain) have shown to slow the growth of tumors.

“…we have discovered that proenzyme therapy, mandated first by John Beard nearly one hundred years ago, shows remarkable selective effects that result in growth inhibition of tumor cells with metastatic potential.”

-Proenzyme therapy of cancer. Novak JF, et al. Anticancer Res. 2005 Mar-Apr.

John Beard, a Scottish doctor, proved the effect of trypsin (a protease taken from a young cow) on halting the growth of tumors in humans by injecting part of the Pancreas of the young cow straight into human tumors.

Papain has been shown to be more powerful of a protease than trypsin.

Papaya Leaf Tea; Enzyme Therapy for Cancer

Papaya Leaf tea can be taken as a form of enzyme therapy. Proteases (protein dissolving enzymes) continue to show effect against cancers in the lab.

Dr Beard, the Scottish embryologist, showed the effect of trypsin (similar to our body’s natural protease) taken from a young calf on human cancerous tumors. The enzyme “ignites” activity in the human body. In Dr Beard’s studies, trypsin injected directly into cancerous tumors appeared to slow down or stop tumor growth.

Why would we need more proteases in our body if it already produces trypsin? Dr Howell, the famous enzyme scientist, addressed that question by the analogy of our bodies having an enzyme “bank” that becomes depleted as we age and when we consume cooked food. The idea is that cooked food does not contain necessary digestive enzymes, so the body essentially must borrow from the “bank”. When the bank becomes depleted of proteases from digesting cooked food it has less ability to use these enzymes for healing.

Additional factors create an environment for cancerous, non-differentiated cells to grow. A Key to changing toxic, low oxygen cellular environments is to give your body the digestive enzymes necessary to function food digestion and remove toxic waste as it builds up in the blood.

Enzyme therapy contributes to this goal. Papaya leaf tea has a very unique set of proteases in nature called papain and chymopapain. These proteolytic enzymes are more powerful than your body’s trypsin.

Papaya leaf tea can be a form of enzyme therapy if taken on a regular basis and for a minimum of three months.

An Alternative Perspective on Cancer

An Alternative Perspective on Cancer and the Immune System:

What is Cancer and How Does It Attack the Body?

-“Immunition Report”, Frank M. Jordan Volume III, Number 5

“The most common cause of death in the U.S. is cancer, accounting currently for 1 in 2 mortalities… Billions spent in research have not dented death statistics.

Cancer is any of a group of more than 200 diseases with symptoms of unrestrained growth of cells in one of the body organs or tissues. The most common form of cancer is carcinoma which originates in the skin or in the glandular tissue such as the breast or prostate gland. Another form of cancer, sarcoma, affects connective and supportive tissue such as bone, muscle, cartilage and fat. Melanomas are more serious, often, but not always, manifested as skin cancers. Lymphomas affect the lymphatic system throughout the body, while leukemias are cancers of the blood-forming organs.

Did you know you probably get cancer up to six times per year, but your immune system when at peak recognizes, attacks and destroys the cancerous cells before potentially deadly growth and multiplication!

Prevention is promoted with proper lifestyle including nutrition, standard and so-called alternative treatments including nutritional supplements. Permissible treatments logically should be expanded to include these same factors proven safe and effective, in addition to the standards of surgery, chemotherapy and radiation to place the patient’s welfare as the number one priority instead of profits and exclusivity.

When not destroyed immediately by your immune system, the new cancer cells avoid the usual controls on growth and multiplication in normal cells. The growth begins when the genes controlling cell growth and multiplication called oncogenes are transformed by cancer-causing agents named carcinogens into cancer cells.

Normal cells can have a malignant change to become a cancer infested cell. These small groups of abnormal cancer cells divide more rapidly than the normal surrounding cells. The fast multiplication results in invasion and destruction of normal body cells. The abnormal cells usually show a lack of “differentiation,” meaning they no longer perform their unique roll as normal cells in maintaining good health. Cancerous cells act as uncontrollable parasites, consuming needed nutrients while contributing nothing except malnutrition.

If not killed and removed, these cancerous cells can then spread (metastasize) via the bloodstream and lymphatic system to other parts of the body from their original site and potentially be fatal if causing organs to fail.

Your immune response is critical to beating or controlling cancer because cancerous tumors develop and multiply when the white immune cells fail to recognize, respond and kill the cancerous cell invaders. If not at peak, the immune response often fails to respond timely when overwhelmed due to the massive number of corrupted cancer cells that have multiplied rapidly when undetected and unchecked.

What Do Cancer and Fetal Development Cells Have in Common?

Cancer cells are similar to fetal development cells called trophoblast that are responsible for the enormous growth from inception to day 55-60. The pancreas then starts working, secreting an enzyme called chymotrypsin. Trophoblast cells are negatively charged with a protein coating that repels white immune cells to prevent your immune system from destroying the developing child.

At the proper time, chymotrypsin destroys the protein coating, the abnormally fast growth ceases and normal baby development continues. Almost all cancer cells unfortunately exhibit this same protein coating with the negative charge that repels immune cells. If pancreatic enzyme production is impaired, as in diabetes or from fungal infections, cancer cells hide from the immune cells thus avoiding attack and removal. Supplemental proteolytic enzymes are believed to be beneficial nutritional supplements in cases of pancreatic enzyme production.

A Healthy Versus Suppressed Immune Response

When your immune response is in peak condition, it is better able to recognize the cancerous cells quickly and respond to kill the health invaders rapidly in most instances. A suppressed or impaired immune response exposes a body to both development and spread (metastasis) of too-often deadly cancer cells in the body.

We are often our own worst enemies instead of helping in our body war against cancer. Diets are poor, we exercise little, rest inadequately and stress too much. Our immune systems are suppressed with excessive free radicals (rogue molecules that damage cells similar to sparking wires) and nutrient delivery is impaired due to high toxicity and high acidity in the body.

Free radicals arrive in toxins entering our systems, including 4,000 legal food additives. Sugar is the food of cancer with a cancer cell having 92 sugar receptors compared to a normal cell with 4! Cancer could be increasing because we now eat an average of 150 lbs a year of sugar compared to only 5 lbs in 1904! Cancer also thrives in an acidic rather than balanced body. Keeping the pH balanced is essential to fighting cancer.

Add polluted air, most tap water; in addition to pathogens such as parasites, fungi, bacteria and viruses. Mix in heavy metals, particularly with dental work and toxic chemicals. Genetic factors damaging cellular DNA (together with caffeine) join immunological weaknesses in certain cancer types and cases.

Present Cancer Treatments – The Facts

The most common treatment in 50% of cancer cases is chemotherapy, but success unfortunately occurs in too few cases (2 to 25%), such as ovarian cancer in women, testicular cancer in men and Duke’s C, a form of colon cancer. Chemo too often shrinks tumor size but does not kill all the cancer cells while damaging other cells. How many cancer patients have heard the words, “We got it all but we want to do preventive chemotherapy to be sure!” Because chemotherapy ingredients often attempt to curtail rapidly multiplying cancer cells, other rapidly multiplying cells such as hair, nails and skin can also be negatively effected (hair loss, pallor, etc.) by multiple treatments.

Dr. Ralph Moss, author of Questioning Chemotherapy, explains most people confuse decreased tumor size with disappearance of disease. The association appears logical, but no known significant proof exists to support the connection. Statistics too often are skewed due to study drop-outs, age limitations on participants and even statistical definitions such as “cure” means an absence of cancer for a five year period from diagnosis.

Even more disturbing, chemotherapy and radiation are recognized carcinogens that can cause rather than cure cancer while increasing dangerous excess acidity which promotes cancer growth. Because of toxicity, chemotherapy and radiation are always spaced out time-wise between treatments, allowing the cancer cells often to multiply rapidly in the interim. Non-toxic alternative treatments do not require time spacing.

The Biopsy Dilemma in Metastasis

An irony can occur during a biopsy of an encapsulated tumor believed to be cancerous because of potential tumor perforation. If the biopsy procedure perforates a malignant tumor, cancer cells are released into the blood stream to metastasize that are otherwise contained. Sadly, a biopsy that can cause metastasis is often performed for legal reasons just before a surgery scheduled to prevent metastasis! If scheduled for cancer tumor surgery, ask for straight answers about the biopsy status and risk before the surgery.

Alternative therapies are often criticized for not being tested according to scientific standards, but many “accepted” treatments, including chemotherapy and radiation, have very limited success, but are both patentable and profitable. In fact, a “cure” is now defined as being alive 5 years after diagnosis – not cured, with present “cure rates” deceptively including non-life-threatening forms of cancer such as simple skin cancers.

This makes cure rates of 50% or more knowingly deceptive by the cancer and pharmaceutical industry due to deceptive statistic practices. This is a moral crime against the victims of cancer in giving knowingly unrealistic “cure” rates. Shouldn’t natural alternatives that have minimal toxic effects on other important functions of the body also be given research funds?

Why Don’t Pharmaceuticals Research and Promote Natural Cancer Treatments?

Alternative treatments are almost universally non-toxic, causing no harm to normal healthy cells in the body while the body is trying to recover from cancer. How can nutrition be an “alternative” treatment while injecting synthetic chemicals is mainstream? Hopefully the answer isn’t money, but the facts too often indicate otherwise. While surgery, chemotherapy and radiation target specific areas of the body, alternative treatments usually approach cancer as a holistic, or whole-body disease; while enhancing the immune response to better attack cancer cells throughout the body. The holistic approach makes sense as research indicates 60-75% of patients diagnosed with cancer have cancer already metastasized.

Why won’t giant pharmaceuticals market natural and alternative cancer treatments? The current system for a cancer drug to be approved by the FDA requires $700+ million dollars and years in research and approval time. Additionally, a natural cancer treatment is not patentable; a protection needed to assure exclusivity and substantial profits for a long-time period.

Being unpatentable makes the extensive time and huge expenditure uneconomic. Unless the system is changed, a natural form of treating cancer will almost certainly never be marketed by a major pharmaceutical. Medical schools also participate in patent profits. Profits – not people – all too often come first! Interrelationships between those regulating and those manufacturing have become more prevalent and disturbing in assessing the possible abuse of objectivity, although most in the regulatory agencies are well-intended and working within a system determined too often by politicians and contributors.

Doctors – Forced Denial by the Present Medical System

Patients many times are not aware that even if their health care provider wants to try a treatment forced to be classified as alternative, in most states the doctor is not legally allowed to prescribe or even recommend anything but surgery, chemotherapy and radiation due to the rigidity of antiquated Standards of Practice or Care.

Doctors often tell patients using alternative therapies to “keep on doing what you’re doing” to avoid personal licensing problems. Are physicians being taught nutrition and other alternative applications in Medical School in a positive and sufficient manner? The answer unfortunately is no, with little change anticipated. Why can’t we use the best of all health sciences with the patient – not the dollar – as our objective in application? The reality is until sick people vote and natural ingredients can produce billions of dollars for profits and contributions, the system priorities will remain with the wrong focus – to the detriment of the cancer victim.”

I choose to publish this perspective because it explains the science of why it is a good idea to add proteolytic enzymes (like chymopapain and papain in the papaya leaf) to your body because they contribute to dissolve the protein coating (similar to chymotrypsin) around cancer cells so that your body can destroy them.


Famous Cancer Scientist, Gonzales, Uses Dr. Kelley’s Study to Prove Effect of Protease Enzyme Therapy for Pancreatic Cancer


Proponent of Protease Enzyme Therapy for Cancer, Dr. Gonzales carefully reviewed prior clinical studies performed by Dr. Kelley at Cornell University and the treatments were shown to have effect. Papaya leaf tea is a form of natural protease enzyme therapy. We have discovered even stronger enzyme activity in papaya leaf tea compared to proteases in pill form.

“Historically, large doses of proteolytic enzymes, along with diet, nutritional supplements, and “detoxification” procedures, have been used in alternative therapies to treat all forms of cancer, without formal clinical studies to support their use.

A 2-year, unblinded, 1-treatment arm, 10-patient, pilot prospective case study was used to assess survival in patients suffering inoperable stage II-IV pancreatic adenocarcinoma treated with large doses of orally ingested pancreatic enzymes, nutritional supplements, “detoxification” procedures, and an organic
diet. From January 1993 to April 1996 in the authors’ private practice, 10 patients with inoperable, biopsy-proven pancreatic adenocarcinoma were entered into the trial. After one patient dropped out, an 11th patient was added to the study (however, all 11 are considered in the data tabulation). Patients followed the treatment at home, under the supervision of the authors. As of 12 January 1999, of 11 patients entered into the study, 9 (81%) survived one year, 5 (45%) survived two years, and at this time, 4 have survived three years. Two patients are alive and doing well: one at three years and the other at four years. These results are far above the 25% survival at one year and 10% survival at two years for all
stages of pancreatic adenocarcinoma reported in the National Cancer Data Base from 1995. This pilot study suggests that an aggressive nutritional therapy with large doses of pancreatic enzymes led to significantly increased survival over what would normally be expected for patients with inoperable pancreatic adenocarcinoma.”

-“Evaluation of Pancreatic Proteolytic Enzyme Treatment of Adenocarcinoma of the Pancreas, With Nutrition and Detoxification Support” Nicholas Gonzales and Linda Lee Isaacs
Nutrition and Cancer, Volume title~content=t775653687~db=all~tab=issueslist~branches=33 – v33 33 , Issue 2
March 1999 , pages 117 – 124

Add Young Papaya Leaves to Your Coffee


Adding young papaya leaf tea to your coffee grounds each morning may save you from a cancer lurking in your body, or from one that you may know very well.

Scientists have shown that it takes three months for the protease papain (found in the papaya leaf) to have full systemic effect in your body. If you are not a tea drinker, or if you know someone who is a coffee drinker, we suggest that you add these leaves to your life.

See more ways to drink young papaya leaf tea at:

Add Young Papaya Leaves to Your Coffee


Adding young papaya leaf tea to your coffee grounds each morning may save you from a cancer lurking in your body, or from one that you may know very well. The enzymes in the leaf may protect your body from viruses or bacterial infections that overused antibiotics can no longer effect. The enzymes in the tea, taken on a regular basis, can clean your blood from build-up. See details at

Scientists have shown that it takes three months for the protease papain (found in the papaya leaf) to have full systemic effect in your body. If you are not a tea drinker, or if you know someone who is a coffee drinker, we suggest that you add these leaves to your life.

See more ways to drink young papaya leaf tea at:

Harvard Graduate Has Patent Pending on Papaya Leaves for Cancer


Dr Nam Dang is a medical oncologist with expertise in the study and treatment of lymphoma and chronic lymphocytic leukemia (CLL). He is Professor and Deputy Chief of the Division of Hematology & Oncology and also is Director of the University of Florida Shands Cancer Center Clinical Trials Office. Dr. Dang received his Phd in Immunology from Harvard.

WE are excited about Dr Dang’s work on papaya leaves and greatly appreciate what he has shown in research on their effect against cancer(s). The Julia Ruffin Project focuses on promoting, growing, and researching papaya leaves. We offer papaya leaves grown from non-genetically modified seeds… just the natural product to markets. The Julia Ruffin Project is non-profit and is not creating additional products from the leaves (such as selling extracted leaf juice) so the patent-pending is not applicable to the young papaya leaves that we grow for market. Go to