Papaya Leaf Tea: Oral Enzyme Therapy

Oral Enzyme Therapy combines various proteases (protein dissolving enzymes) in order to prevent disease, assist the body to fight various cancers, and lessen the negative effects of chemotherapy and radiation. The proteolytic enzymes papain and chymopapain are found naturally in the papaya leaf.

Memorial Sloan Cancer Center Site explains possible Mechanism of Action:
“PEs (proteolytic enzymes) are thought to exert immunomodulatory effects by causing increased release of reactive oxygen species by polymorphonuclear leukocytes (7) or by production of tumor necrosis factor-alpha and interleukins IL-6 and IL-1B that cause cytotoxic effects (1) (2). The antiangiogenic effects that papain exhibits in VEGF-activated human endothelial cells is concentration-dependent and likely due to interference with AKT, MEK1/2 and SAPK/JNK phosphorylation (15). Bromelain has been shown to lower the tumorigenic/metastatic capacities of sarcoma L-1 cells (3). It also inhibited glioma cell migration and invasion by affecting expression of integrins, necessary for cellular migration and invasion (5). In B16 murine melanoma models, PEs inhibited metastasis by reducing expression of CD44 and CD54 molecules (6).”

One example of a clinical trial that documented the lessened effect of radiation on cancer patients who took oral enzyme therapy is below:

Co-medication with hydrolytic enzymes in radiation therapy of uterine cervix: evidence of the reduction of acute side effects.

Dale PS1, Tamhankar CP, George D, Daftary GV.
Cancer Chemother Pharmacol. 2001 Jul;47 Suppl:S29-34.

“CONCLUSIONS: In patients with locally advanced cancer of the uterine cervix, oral enzyme therapy was found to be effective in significantly reducing radiation therapy-related side effects such as genitourinary symptoms, subcutaneous changes and reactions of the vaginal mucosa.”

In another clinical study, oral enzyme therapy was an effective complementary treatment for patients undergoing chemotherapy and radiation:

“…CONCLUSION: Complementary treatment of colorectal cancer patients with OE improves their quality of life by reducing both the signs and symptoms of the disease and the adverse reactions associated with adjuvant antineoplastic therapies. This epidemiological retrolective cohort analysis provides evidence that patients may also benefit by a prolongation of survival time. OE were generally well tolerated.”

PMID 11561874 [PubMed – indexed for MEDLINE]

Influence of a complementary treatment with oral enzymes on patients with colorectal cancers–an epidemiological retrolective cohort study.

Popiela T1, Kulig J, Hanisch J, Bock PR.
Cancer Chemother Pharmacol. 2001 Jul;47 Suppl:S55-63.

Papaya Leaf Tea as a natural oral enzyme therapy solution may contain a more complete set of necessary compounds to allow for absorption by the body. This theory is presented in part in the blog below:

Picture above; Mr Jacob Jeyasekaran
Of the Julia Ruffin Project

The Julia Ruffin Project promotes, researches, and test-farms papaya leaf tea.