Papaya Leaf May Slow Development of Atherosclerosis

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Scientists at Mexican Universities in Villahermosa and Comalcalco have discovered that papaya leaf reduces the build-up of fats in the blood. Given this function, papaya leaf may be able to assist in slowing development of atherosclerosis.

“Hyperlipidemia plays an important role in the development of atherosclerosis, the main cause of death in the world. In this study, the lipid-lowering effect of Carica papaya leaf in rats fed with a high cholesterol diet was evaluated…”

“…Our data support that C. papaya has a significant hypocholesterolemic action and HDL-C raising effect on rats fed with a cholesterol-rich diet, however, the precise metabolites responsible of this effect remain unknown.”

Effect of Carica papaya Leaf Extract on Serum Lipids and Liver Metabolic Parameters of Rats Fed a High Cholesterol Diet

Alma M. Zetina-Esquivel1, Carlos A. Tovilla-Zárate2, Crystell Guzmán-Garcia1, Arturo Rodríguez-Hernández3, Andrés E. Castell-Rodríguez4, Jorge L. Ble-Castillo1, Angela Avila-Fernandez1, Isela E. Juárez-Rojop1*, Juan C. Díaz-Zagoya4
Affiliation(s)
1Centro de Investigación, División Académica de Ciencias de la Salud, Universidad Juárez Autónoma de Tabasco, Villahermosa, México.
2División Académica Multidisciplinaria de Comalcalco, Universidad Juárez Autónoma de Tabasco, Comalcalco, México.
3Unidad de Medicina Familiar 10, Instituto Mexicano del Seguro Social, Xalapa, México.
4División de Investigación, Facultad de Medicina, Universidad Nacional Autónoma de México, México, D. F., México.

http://www.scirp.org/journal/PaperInformation.aspx?PaperID=59952

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International Pharmaceutical Journal: Papaya Leaf Cancer Prevention Reviewed in Saudi Arabia

This research paper just published this year, 2016, gave a concise five page summary of papaya and its effect on disease. Dr Dang’s original research at the University of Florida was referenced related to papaya leaf and its effect on cancer.

“Plants products or constituent of the plants shows therapeutics role in the cancer prevention and treatment [37]. In this regards, papaya and their valuable constituents have a significant role in the cancer management. An important study examined the effect of aqueous- extracted C. papaya leaf fraction on the growth of various tumor cell lines and on the anti-tumor effect of human lymphocytes and results showed that growth inhibitory activity of the CP extract on tumor cell lines derived from cervical carcinoma (Hela), breast adenocarcinoma (MCF-7), hepatocellular carcinoma (HepG2), lung adenocarcinoma (PC14), pancreatic epithelioid carcinoma (Panc-1), and mesothelioma (H2452) in a dose-dependent manner. In addition, CP extract inhibited the proliferative responses of haematopoietic cell lines, including T-cell lymphoma (Jurkat), plasma cell leukemia (ARH77), Burkitt’s lymphoma a (Raji), and anaplastic large cell lymphoma (Karpas-299) [38].”

POTENTIAL ROLE OF CARICA PAPAYA AND THEIR ACTIVE CONSTITUENTS IN THE PREVENTION AND TREATMENT OF DISEASES
ARSHAD H RAHMANI1, YOUSEF H ALDEBASI2
1Department of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Saudi Arabia, 2Department of Optometry, College of Applied Medical Sciences, Qassim University, Saudi Arabia
Email: rehmani.arshad@gmail.com

http://innovareacademics.in/journals/index.php/ijpps/article/download/8891/pdf

Papaya Leaf Shows Effect on Skin Cancer in Lab

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A very special publication on Christmas Eve, 2015 shows the hard work in Australia to prove the inhibitive effect of papaya leaf on the second most common type of skin cancer, squamous cells.

” In this study, we investigated the in vitro cytotoxicity of aqueous and ethanolic extracts of Carica papaya leaves on the human oral squamous cell carcinoma SCC25 cell line in parallel with non-cancerous human keratinocyte HaCaT cells. Two out of four extracts showed a significantly selective effect towards the cancer cells and were found to contain high levels of phenolic and flavonoid compounds…

The principal compounds [in papaya leaf] identified were flavonoids or flavonoid glycosides, particularly compounds from the kaempferol and quercetin families, of which several have previously been reported to possess anticancer activities. These results confirm that papaya leaf is a potential source of anticancer compounds and warrant further scientific investigation to validate the traditional use of papaya leaf to treat cancer.”

Chemical Characterization and in Vitro Cytotoxicity on Squamous Cell Carcinoma Cells of Carica Papaya Leaf Extracts
Thao T. Nguyen 1, Marie-Odile Parat 1, Mark P. Hodson 1,2, Jenny Pan 1, Paul N. Shaw 1 and Amitha K. Hewavitharana 1,*
Received: 26 October 2015; Accepted: 18 December 2015; Published: 24 December 2015 Academic Editor: Carmela Fimognari

http://www.mdpi.com/2072-6651/8/1/7/pdf

Papaya Leaf Shows Anti-Proliferative Effect on Prostate Cancer Cells

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DOI: 10.1111/bju.13198
Conference: Prostate Cancer World Congress-August, 2015, At Cairns Convention Centre, Australia

“This study has shown that anti-Proliferative responses to papaya [leaf juice] extracts.”

Carica papaya leaf juice extracts have selective anti-proliferative responses in prostatic disease

http://www.researchgate.net/publication/281526213_Carica_papaya_leaf_juice_extracts_have_selective_anti-proliferative_responses_in_prostatic_disease

This blog sponsored by the Julia Ruffin Project: researching, promoting, and growing papaya leaves for cancer

Papaya Leaf Shows Activity Against E-Coli: Research Published by International Journal

“The leaves of Carica papaya are used in herbal medical practices in South East Nigeria to treat malaria and typhoid fever which engendered a probe of its chemical constituents…
The extract showed potent antimicrobial activity against Staphylococcus aureus,streptococcus faecalis, Escherichia coli and Proteus mirabilis… This research lends credence to the use of C. papaya in herbal medicine in Nigeria.”

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CHEMICAL CONSTITUENTS OF THE LEAF ESSENTIAL OIL OF CARICA PAPAYA FROM SOUTH EAST NIGERIA
AND ITS ANTIMICROBIAL ACTIVITY

OU. Igwe
Department of Chemistry, Michael Okpara University of Agriculture, Umudike, P.M.B. 7267 Umuahia, Abia State, Nigeria.
IJRPC 2015, 5(1), 77-83 Igwe ISSN: 22312781 INTERNATIONAL JOURNAL OF RESEARCH IN PHARMACY AND CHEMISTRY

Papaya Leaf for Dengue in Delhi

“Delhi government struggles with dengue outbreak
Extra hospital beds ordered and medical-staff leave cancelled amid warning situation in Indian capital could worsen.”
Showkat Shafi | 19 Sep 2015 10:30 GMT | Health, Dengue, India, Asia
http://www.aljazeera.com/news/2015/09/delhi-government-struggles-dengue-outbreak-150919053907482.html

A respected European Journal notes the Aryvetic approach to managing dengue fever.

Given the recommendation to treat with papaya leaf, and the abundance of this herb in India, it may be profitable to society for papaya plantations to supply hospitals in Delhi with leaves (given the reported nature of the current health crisis.)

“The juice of papaya leaf has been found to be useful in the treatment of dengue fever. A number of scientific papers have proved that papaya leaf juice is actually beneficial for the body. Few recent studies have shown the effect of papaya leaf juice in curing the dengue fever. A recent one, done on five dengue patients by Indian Institute of Forest Management in 2012, found interesting observations. Among the five patients, papaya leaf juice was found to be effective in curing dengue. The platelet count increased in all five patients within 24 hours of drinking the papaya leaf juice. All of them reported significant improvement in health.[10]
A 2009 study, done on mice in Malaysia, reported significant improvement in thrombolytic count in the group which received papaya leaf formulations compared to the control group. It seems that this bitter green juice is promising without posing any serious ill-effects.”

ejpmr, 2015,2(4), 693
EUROPEAN JOURNAL OF PHARMACEUTICAL AND MEDICAL RESEARCH
http://www.ejpmr.com
Research Article search
ISSN 3294-3211
EJPMR
“AN AYURVEDIC INSIGHT TOWARDS DENGUE FEVER”
Dr. Sumit Srivastava*
Associate Professor, Dept. of Rog-nidan, Shri Dhanwantry Ayurvedic College, Chandigarh.
Article Received on 18/05/2015 Article Revised on 12/06/2015 Article Accepted on 04/07/2015

http://archive.indianexpress.com/news/bitter-treatment-papaya-leaves-can-fight-dengue- cancer/1178680/.

The Julia Ruffin Project promotes and researches papaya leaf for its effect on cancer and disease.

Papaya Leaf Slows Free Radical Destruction that Causes Aging and Cancer

We have published research articles that show the healing effect of papaya leaf on the liver. But this study explains how this action also has anti-aging and anti-cancer effects:

From the International Journal of Pharmacy

“…In general up on entry of any foreign particle enters in to our body. Free radicals can be generated, which is based on the size of the foreign particle or physico chemical characteristics of that foreign particle (1). The free radicals are not inactivated; their chemical reactivity can damage all cellular macromolecules including proteins, carbohydrates, lipids and nucleic acids. Their destructive effect on protein may play a role in the causation of diseases, like cataracts. Free radical damage to DNA is also implicated in the causation of cancer and its effect on LDL cholesterol is very likely responsible for heart disease. Free radicals are also responsible for ageing (2).
Iron over load causes liver toxicity by producing hydroxyl radicals by promoting Fenton reaction(3). Free radicals also can be able to cause various
diseases like neurodegenerative diseases (4), cardio vascular diseases (5), cancer etc. So the work started because of these serious effects up on the free radical generation, expecting that Herbal medicines have been used able to generate antioxidants, which can be provide balance between free radical generation and anti-oxidant levels or those anti-oxidants prevents the liver damage and gastric ulceration caused by free radicals….
In present study the antioxidant activity of aqueous extract of leaf of Carica papaya was found. From the study it was also found to decrease lipid peroxidation and significant increase in catalase, glutathione and protein with the aqueous extract of leaf of Carica papaya in dose dependant manner. Literature regarding phytoconstituents shows that aqueous extract of leaf of Carica papaya contains Alkaloids Carpain, Pseudo carpain, and dehydro carpaine I & II, Choline, Caproside, Vitamin C & E. Since all these constituents are found in the leaf of this plant it is possible that these constituents may be implicated in antioxidant activity of the species. Therefore, it was concluded that the aqueous extract of the leaf of Carica papaya possess antioxidant principles and has free radical scavenging activity.
CONCLUSION
The result have shown that the aqueous extract of the leaf of Carica papaya possesses antioxidant properties, supported by the decrease in lipid peroxidation and increase in the reduced glutathione and catalase activity in in vivo method. The in vivo antioxidant activities have been supported by its free radical scavenging activities in in-vitro method. Such antioxidant activity of Carica papaya might be responsible for its importance in traditional medicine for the treatment of various disorders. The present study opens many new areas of research work. This work can be continued in the future to study and confirm liver protective activity in different experimental models and also to isolate, identify, characterize and standardize the active principle(s) that are responsible for this activity.”

-IRON OVER LOAD INDUCED LIVER TOXICITY OF AQUEOUS LEAF EXTRACT
OF CARICA PAPAYA IN RATS
Balakrishna V*, Srikanth G, Ajay kumar Sarabu, Thippani Maneshwar
Department of Pharmacology, Vaageswari College of Pharamacy, Karimnagar, Andhra Pradesh, India
International Journal of Pharmacy
Journal Homepage: http://www.pharmascholars.com