Papaya Leaf for the Natural and Affordable War on TB

A recent article in Aljazeera documents the desperate poverty, a shortage of funding for TB medication, and developing resistance to TB drugs in Madagascar.

Madagascar: The vulnerability to tuberculosis

New research in India has shown the potential of papaya leaf for its effect on TB.

“…By using alamar blue dye assay and in-vitro bioassay based on inactivation of viability by a procedure similar to neutralization test were used to study the inhibition of Mycobacterium tuberculosis which shows anti-tb activity against clinical strains of sensitive and drug resistant Mycobacterium tuberculosis (pyrazinamide, streptomycin, ciprofloxacin). The present results are possibly one of the first few investigations showing a clear indication of the potent anti-tubercular effect of carica papaya.”

Naga Swathi Sree Kavuri, Sravani Yangalasetti, Venkata Rao Vutla. Anti-tubercular Activity of Leaf and Seed Extract of Carica papaya. Inventi Rapid: Planta Activa, 2016(1): 1-3, 2015

Papaya Leaf: Don’t Boil it. Brew it.

In a new study that investigated the effect of aboriginal methods using papaya leaf for medicinal effects, the researchers found that the traditional decoctions (boiling the leaves) had LESS effect on cancer cells than the fresh juice from the leaves. This research result is not surprising, as the enzyme papain in the leaf is most effective at 150-160 degrees F. 

The researchers also called their alternative boiling method “brewing”…as in “brewing” tea. 

Tea enthusiasts would not connect to this definition as “brewing” tea is a delicate act of boiling water, letting it cool to the proper temperature, (typically 150-160 F) then pouring over the tea. 

Related to its (papaya leaf tea) effect on cancer, I would encourage the scientists to test again a true, “classically brewed” papaya leaf against the papaya juice to find its effect on this set of cancer cells in the lab.

Again, it is glorious to see strong research indicating the selective effect of papaya leaf on SCC25 cancer cells. Exciting research. Thank you to the team in Australia!!

Traditional Aboriginal Preparation Alters the Chemical Profile of Carica papaya Leaves and Impacts on Cytotoxicity towards Human Squamous Cell Carcinoma

Feb 1, 2016

Thao T. Nguyen1, Marie-Odile Parat1, Paul N. Shaw1, Amitha K. Hewavitharana1, Mark P. Hodson1,2*
1 School of Pharmacy, The University of Queensland, Brisbane, Queensland, Australia, 2 Metabolomics Australia, Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, Queensland, Australia

Papaya Leaves Beat Standard Antibiotics in Lab

According to the International Journal of Herbs and Pharmocological Research:



1Orhue P.O. and *2Momoh A.R.M.

In this research where a petroleum extract of papaya leaf was compared to two common antibiotics, Perflacine and Cefuroxime on bacterial organisms S Aureus, E-Coli, and P aeruginosa, papaya leaf was found to be more powerful.

Their chart below…Orhue%20and%20Momoh.,%202(4)%202013.pdf

Papaya Leaf Listed for AntiDiabetic Potential in Cuba

Papaya Leaf was one among a list of seventeen herbal candidates for potential diabetes treatment in Cuba.

“Carica papaya L. (C. papaya)
Traditional use to treat diabetes in: USA 17, Trinidad and Tobago44, Mexico47, Nigeria 48. India49 Hypoglycemic potential of C. papaya leaf aqueous extract was demonstrated by lowering of fasting blood glucose levels in rats with Streptozotocin – and Aloxan.- induced diabetes that were orally treated with this product 50, 51.”

Antidiabetic potential of plants used in Cuba
García Mesa, M.
National Institute of Angiology and Vascular Surgery, 1551 Calzada del Cerro, 12000 Cerro, Havana, Cuba

Pharmacology Online
Archives • 2014 • vol.1 •52-62
April 30, 2014

What Type of Cancer Has Papaya Leaf Shown to Affect?

Sheikh Fauziya in his paper, “Papaya: Source for Anticancer”, created a summary of the types of cancer lines studied so far that papaya leaf has shown to affect:

Stomach Cancer
Pancreatic Cancer
Colon Cancer
Ovarian Cancer
Lymphoma Cancer
Breast Cancer
Neuroblastoma Cancer
Uterine Cancer
Leukemia Cancer
Cervical Cancer
Hepatocellular Cancer

-CIBTech Journal of Pharmaceutical Sciences ISSN: 2319–3891 (Online)
An Online International Journal Available at 2013 Vol.2 (1) January-March, pp.25-34/Sheikh and Krishnamurthy
Review Article
*Sheikh Fauziya and R Krishnamurthy
CG Bhakta Institute of Biotechnology, Uka Tarsadia University, Maliba Campus Bardoli, Dist. Surat, Gujarat, India-394350
*Author for Correspondence…Krishnamurthy…Papaya…Anticancer…25-33.pdf

Nine Dengue Patients Observed Recovered With Papaya Leaf

A test of the effect of papaya leaf on nine patients with Dengue Fever was published in India last Spring:

“In the present study we found the therapeutic potential of papaya leaf extract (PLE) in curing dengue infection by increasing platelet and WBC counts respectively. Ultrasonographic findings, blood reports, statistical analysis and patient’s recovery from dengue infection further supported the culinary effect of papaya leaf extract (PLE) in dengue patients. The nontoxic nature of PLE also supports its use as natural herbal remedy for dengue infection. An earlier study categorized Carica papaya leaf as non toxic (LD50 >15g per Kg body weight) (Kardono et al., 2003).”

-International Journal of Applied Biology and Pharmaceutical Technology
C.V.M. Naresh Kumar1,2, V. Taranath1, A. Venkatamuni3 , R. Vishnu Vardhan4, Y. Siva Prasad1, U. Ravi3 and D.V.R. Sai Gopal1,2*
1Department of Virology, College of Sciences, Sri Venkateswara University, Tirupati -517 502, Andhra Pradesh, India
2Department of Science and Technology-Promotion of University Research and Scientific Excellence Centre (DST-PURSE CENTRE), Sri Venkateswara University, Tirupati -517 502, Andhra Pradesh, India 3Vishnu Sri Hospital, Korlagunta Main Road, Tirupati -517 502, Andhra Pradesh, India 4Department of Statistics, Pondicherry University, Puducherry – 14, India *Corresponding author Email:

Ayurvedic Practitioner Dr Valerian Mendonca: Papaya Leaves for Chikungunya


“…Herbal medicine in India has been saving lives for thousands of years. Ayurveda is probably as old as the Indus Valley Civilization dating back to 3000 BC. All four Vedas especially the Rig Veda carry references to diseases and their cures through herbs and roots.

The ancient art of Ayurveda was systematically killed by the colonialists when they took over the country. It was suppressed by the British. The East India Company banned and shut down all Ayurvedic colleges in 1833. When Ayurveda re-emerged for almost 100 years, herbal remedies were dismissed as “the poor man’s medicine” practiced in rural areas where western medicine was too expensive or not available. The irony was the country folk were healthier than the urban class.

The Portuguese in Goa actually did shut down Ayurvedic practitioners. The Vaidyas of Hindu Pharmacy were the only Ayurvedic dispensers allowed to practice after one of them saved the life of a Viceroy’s wife.

Only now more and more patients are realising that allopathy or Western Medicine is not just expensive, but has hidden side effects that cause more problems than the original ailment itself.

When the Chikungunya outbreak happened a couple of years ago, The Times of India Mumbai edition carried an article on the effectiveness of the papaya leaf juice cure to completely eliminate the crippling joint pains that kicked in after the fever ended. My brother read the article and was so desperate to try anything to get back to his active life that he experimented with the papaya cure. It worked the same day. He had another two tablespoons the next day and was 100 percent fit.”

Dr Valerian Mendonca
Papaya for Chikungunya and Dengue (Adapted from an email forward)

The Julia Ruffin Project researches, grows, and publishes the medicinal benefits of papaya leaf