Papaya Leaf Listed for AntiDiabetic Potential in Cuba

Papaya Leaf was one among a list of seventeen herbal candidates for potential diabetes treatment in Cuba.

“Carica papaya L. (C. papaya)
Traditional use to treat diabetes in: USA 17, Trinidad and Tobago44, Mexico47, Nigeria 48. India49 Hypoglycemic potential of C. papaya leaf aqueous extract was demonstrated by lowering of fasting blood glucose levels in rats with Streptozotocin – and Aloxan.- induced diabetes that were orally treated with this product 50, 51.”

Antidiabetic potential of plants used in Cuba
García Mesa, M.
National Institute of Angiology and Vascular Surgery, 1551 Calzada del Cerro, 12000 Cerro, Havana, Cuba

Pharmacology Online
Archives • 2014 • vol.1 •52-62
April 30, 2014

Click to access PhOL_2014_1_A08_Mesa1.pdf

What Type of Cancer Has Papaya Leaf Shown to Affect?

Sheikh Fauziya in his paper, “Papaya: Source for Anticancer”, created a summary of the types of cancer lines studied so far that papaya leaf has shown to affect:

Stomach Cancer
Pancreatic Cancer
Colon Cancer
Ovarian Cancer
Lymphoma Cancer
Breast Cancer
Neuroblastoma Cancer
Uterine Cancer
Leukemia Cancer
Cervical Cancer
Hepatocellular Cancer

-CIBTech Journal of Pharmaceutical Sciences ISSN: 2319–3891 (Online)
An Online International Journal Available at 2013 Vol.2 (1) January-March, pp.25-34/Sheikh and Krishnamurthy
Review Article
*Sheikh Fauziya and R Krishnamurthy
CG Bhakta Institute of Biotechnology, Uka Tarsadia University, Maliba Campus Bardoli, Dist. Surat, Gujarat, India-394350
*Author for Correspondence

Click to access 05-008…Krishnamurthy…Papaya…Anticancer…25-33.pdf

Nine Dengue Patients Observed Recovered With Papaya Leaf

A test of the effect of papaya leaf on nine patients with Dengue Fever was published in India last Spring:

“In the present study we found the therapeutic potential of papaya leaf extract (PLE) in curing dengue infection by increasing platelet and WBC counts respectively. Ultrasonographic findings, blood reports, statistical analysis and patient’s recovery from dengue infection further supported the culinary effect of papaya leaf extract (PLE) in dengue patients. The nontoxic nature of PLE also supports its use as natural herbal remedy for dengue infection. An earlier study categorized Carica papaya leaf as non toxic (LD50 >15g per Kg body weight) (Kardono et al., 2003).”

-International Journal of Applied Biology and Pharmaceutical Technology
C.V.M. Naresh Kumar1,2, V. Taranath1, A. Venkatamuni3 , R. Vishnu Vardhan4, Y. Siva Prasad1, U. Ravi3 and D.V.R. Sai Gopal1,2*
1Department of Virology, College of Sciences, Sri Venkateswara University, Tirupati -517 502, Andhra Pradesh, India
2Department of Science and Technology-Promotion of University Research and Scientific Excellence Centre (DST-PURSE CENTRE), Sri Venkateswara University, Tirupati -517 502, Andhra Pradesh, India 3Vishnu Sri Hospital, Korlagunta Main Road, Tirupati -517 502, Andhra Pradesh, India 4Department of Statistics, Pondicherry University, Puducherry – 14, India *Corresponding author Email:

Click to access therapeutic-potential-of-carica-papaya-l-leaf-extract-in-treatment-ofdengue-patients.pdf

Ayurvedic Practitioner Dr Valerian Mendonca: Papaya Leaves for Chikungunya


“…Herbal medicine in India has been saving lives for thousands of years. Ayurveda is probably as old as the Indus Valley Civilization dating back to 3000 BC. All four Vedas especially the Rig Veda carry references to diseases and their cures through herbs and roots.

The ancient art of Ayurveda was systematically killed by the colonialists when they took over the country. It was suppressed by the British. The East India Company banned and shut down all Ayurvedic colleges in 1833. When Ayurveda re-emerged for almost 100 years, herbal remedies were dismissed as “the poor man’s medicine” practiced in rural areas where western medicine was too expensive or not available. The irony was the country folk were healthier than the urban class.

The Portuguese in Goa actually did shut down Ayurvedic practitioners. The Vaidyas of Hindu Pharmacy were the only Ayurvedic dispensers allowed to practice after one of them saved the life of a Viceroy’s wife.

Only now more and more patients are realising that allopathy or Western Medicine is not just expensive, but has hidden side effects that cause more problems than the original ailment itself.

When the Chikungunya outbreak happened a couple of years ago, The Times of India Mumbai edition carried an article on the effectiveness of the papaya leaf juice cure to completely eliminate the crippling joint pains that kicked in after the fever ended. My brother read the article and was so desperate to try anything to get back to his active life that he experimented with the papaya cure. It worked the same day. He had another two tablespoons the next day and was 100 percent fit.”

Dr Valerian Mendonca
Papaya for Chikungunya and Dengue (Adapted from an email forward)

The Julia Ruffin Project researches, grows, and publishes the medicinal benefits of papaya leaf


Papaya Leaf Determined To Be Safe. Again.

Scientists continue to study papaya leaf to be assured of its safety. It has been shown as “Hepatoprotective” (safe for the liver) Orhan, D.D.; Orhan, N.; Ergun, E.; Ergun, F. Hepatoprotective effect of Vitis vinifera L. leaves on carbon tetrachloride-induced acute liver damage in rats. J. Ethnopharmacol. 2007, 112, 145–151.

A study in 2011 tested the toxicity of papaya leaf
Halim, S.; Abdullah, N.R.; Afzan, A.; Rashid, B.A.A.; Jantan, I.; Ismail, Z. Study of acute toxicity
of Carica papaya leaf extract in Sprague Dawley rats. J. Med. Plants Res. 2011, 5, 1867–1872

And in 2012 another study related to the safety of papaya leaf in malaysia:

“…analysis revealed that the leaf extract of C. papaya cultivar ‘Sekaki’ contains considerable amounts of carpaine, malic acid, quinic acid, manghaslin and clitorin, minor quantities of various malic acid derivatives, nicotiflorin, rutin and unidentified unknown constituents. These complex mixtures did not produce treatment related changes in body weight, food intake, water level, hematological parameters and serum biochemistry in Sprague Dawley rats after oral sub-acute exposure for 28 days.”

Repeated Dose 28-Days Oral Toxicity Study of Carica papaya L. Leaf Extract in Sprague Dawley Rats
Adlin Afzan 1,*, Noor Rain Abdullah 1,2, Siti Zaleha Halim 1, Badrul Amini Rashid 1,
Raja Hazlini Raja Semail 1, Noordini Abdullah 1, Ibrahim Jantan 3, Hussin Muhammad 1 and Zakiah Ismail 1
ISSN 1420-3049

Papaya Leaf May Slow Development of Atherosclerosis


Scientists at Mexican Universities in Villahermosa and Comalcalco have discovered that papaya leaf reduces the build-up of fats in the blood. Given this function, papaya leaf may be able to assist in slowing development of atherosclerosis.

“Hyperlipidemia plays an important role in the development of atherosclerosis, the main cause of death in the world. In this study, the lipid-lowering effect of Carica papaya leaf in rats fed with a high cholesterol diet was evaluated…”

“…Our data support that C. papaya has a significant hypocholesterolemic action and HDL-C raising effect on rats fed with a cholesterol-rich diet, however, the precise metabolites responsible of this effect remain unknown.”

Effect of Carica papaya Leaf Extract on Serum Lipids and Liver Metabolic Parameters of Rats Fed a High Cholesterol Diet

Alma M. Zetina-Esquivel1, Carlos A. Tovilla-Zárate2, Crystell Guzmán-Garcia1, Arturo Rodríguez-Hernández3, Andrés E. Castell-Rodríguez4, Jorge L. Ble-Castillo1, Angela Avila-Fernandez1, Isela E. Juárez-Rojop1*, Juan C. Díaz-Zagoya4
1Centro de Investigación, División Académica de Ciencias de la Salud, Universidad Juárez Autónoma de Tabasco, Villahermosa, México.
2División Académica Multidisciplinaria de Comalcalco, Universidad Juárez Autónoma de Tabasco, Comalcalco, México.
3Unidad de Medicina Familiar 10, Instituto Mexicano del Seguro Social, Xalapa, México.
4División de Investigación, Facultad de Medicina, Universidad Nacional Autónoma de México, México, D. F., México.

International Pharmaceutical Journal: Papaya Leaf Cancer Prevention Reviewed in Saudi Arabia

This research paper just published this year, 2016, gave a concise five page summary of papaya and its effect on disease. Dr Dang’s original research at the University of Florida was referenced related to papaya leaf and its effect on cancer.

“Plants products or constituent of the plants shows therapeutics role in the cancer prevention and treatment [37]. In this regards, papaya and their valuable constituents have a significant role in the cancer management. An important study examined the effect of aqueous- extracted C. papaya leaf fraction on the growth of various tumor cell lines and on the anti-tumor effect of human lymphocytes and results showed that growth inhibitory activity of the CP extract on tumor cell lines derived from cervical carcinoma (Hela), breast adenocarcinoma (MCF-7), hepatocellular carcinoma (HepG2), lung adenocarcinoma (PC14), pancreatic epithelioid carcinoma (Panc-1), and mesothelioma (H2452) in a dose-dependent manner. In addition, CP extract inhibited the proliferative responses of haematopoietic cell lines, including T-cell lymphoma (Jurkat), plasma cell leukemia (ARH77), Burkitt’s lymphoma a (Raji), and anaplastic large cell lymphoma (Karpas-299) [38].”

1Department of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Saudi Arabia, 2Department of Optometry, College of Applied Medical Sciences, Qassim University, Saudi Arabia

Papaya Leaf Shows Effect on Skin Cancer in Lab

A very special publication on Christmas Eve, 2015 shows the hard work in Australia to prove the inhibitive effect of papaya leaf on the second most common type of skin cancer, squamous cells.

” In this study, we investigated the in vitro cytotoxicity of aqueous and ethanolic extracts of Carica papaya leaves on the human oral squamous cell carcinoma SCC25 cell line in parallel with non-cancerous human keratinocyte HaCaT cells. Two out of four extracts showed a significantly selective effect towards the cancer cells and were found to contain high levels of phenolic and flavonoid compounds…

The principal compounds [in papaya leaf] identified were flavonoids or flavonoid glycosides, particularly compounds from the kaempferol and quercetin families, of which several have previously been reported to possess anticancer activities. These results confirm that papaya leaf is a potential source of anticancer compounds and warrant further scientific investigation to validate the traditional use of papaya leaf to treat cancer.”

Chemical Characterization and in Vitro Cytotoxicity on Squamous Cell Carcinoma Cells of Carica Papaya Leaf Extracts
Thao T. Nguyen 1, Marie-Odile Parat 1, Mark P. Hodson 1,2, Jenny Pan 1, Paul N. Shaw 1 and Amitha K. Hewavitharana 1,*
Received: 26 October 2015; Accepted: 18 December 2015; Published: 24 December 2015 Academic Editor: Carmela Fimognari

Papaya Leaf Shows Anti-Proliferative Effect on Prostate Cancer Cells

DOI: 10.1111/bju.13198
Conference: Prostate Cancer World Congress-August, 2015, At Cairns Convention Centre, Australia

“This study has shown that anti-Proliferative responses to papaya [leaf juice] extracts.”

Carica papaya leaf juice extracts have selective anti-proliferative responses in prostatic disease

This blog sponsored by the Julia Ruffin Project: researching, promoting, and growing papaya leaves for cancer

Papaya Leaf Shows Activity Against E-Coli: Research Published by International Journal

“The leaves of Carica papaya are used in herbal medical practices in South East Nigeria to treat malaria and typhoid fever which engendered a probe of its chemical constituents…
The extract showed potent antimicrobial activity against Staphylococcus aureus,streptococcus faecalis, Escherichia coli and Proteus mirabilis… This research lends credence to the use of C. papaya in herbal medicine in Nigeria.”



OU. Igwe
Department of Chemistry, Michael Okpara University of Agriculture, Umudike, P.M.B. 7267 Umuahia, Abia State, Nigeria.