Papaya Leaf Determined To Be Safe. Again.

Scientists continue to study papaya leaf to be assured of its safety. It has been shown as “Hepatoprotective” (safe for the liver) Orhan, D.D.; Orhan, N.; Ergun, E.; Ergun, F. Hepatoprotective effect of Vitis vinifera L. leaves on carbon tetrachloride-induced acute liver damage in rats. J. Ethnopharmacol. 2007, 112, 145–151.

A study in 2011 tested the toxicity of papaya leaf
Halim, S.; Abdullah, N.R.; Afzan, A.; Rashid, B.A.A.; Jantan, I.; Ismail, Z. Study of acute toxicity
of Carica papaya leaf extract in Sprague Dawley rats. J. Med. Plants Res. 2011, 5, 1867–1872

And in 2012 another study related to the safety of papaya leaf in malaysia:

“…analysis revealed that the leaf extract of C. papaya cultivar ‘Sekaki’ contains considerable amounts of carpaine, malic acid, quinic acid, manghaslin and clitorin, minor quantities of various malic acid derivatives, nicotiflorin, rutin and unidentified unknown constituents. These complex mixtures did not produce treatment related changes in body weight, food intake, water level, hematological parameters and serum biochemistry in Sprague Dawley rats after oral sub-acute exposure for 28 days.”

Repeated Dose 28-Days Oral Toxicity Study of Carica papaya L. Leaf Extract in Sprague Dawley Rats
Adlin Afzan 1,*, Noor Rain Abdullah 1,2, Siti Zaleha Halim 1, Badrul Amini Rashid 1,
Raja Hazlini Raja Semail 1, Noordini Abdullah 1, Ibrahim Jantan 3, Hussin Muhammad 1 and Zakiah Ismail 1
molecules
ISSN 1420-3049
http://www.mdpi.com/journal/molecules

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Flavonoids make Papaya Leaf Tea Safe

In 2011 Brazilian scientists wanted to show that the apparent positive effect of papaya leaf on cancers was not toxic to the body.

The study used standard methods for discovery on this subject, and in the final analysis the study showed that papaya leaf is non-toxic by these methods and also disclosed the most likely substance in the papaya leaf that is responsible: it is the flavonoid in the leaf called rutin.

“…The results of this study indicated that an aqueous solution of the ethanolic extract of leaves of C. papaya, under the experimental conditions used, has low toxicity and an antimutagenic effect; flavonoids, such as rutin, may be the substances involved in this action.”

http://serv-bib.fcfar.unesp.br/seer/index.php/Cien_Farm/article/viewFile/1993/1187

Antimutagenic activity of Carica papaya L. assayed in vivo by micronucleus test
Kalil, I.C.1; Gibson, B.A.V.1; Ribeiro, C.A.1; Benincá, L.S.1; Brasil, G.A.1; Andrade, T.U.1; Batitucci, M.C.P.2; Endringer, D.C.1*
1 Curso de Farmácia, Universidade Vila Velha – UVV 2 Universidade Federal do Espírito Santo – UFES
Recebido 22/09/2011 / Aceito 17/11/2011

Papaya Leaf In Large Doses Tests Safe

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Malaysian lab study advises that papaya leaf shows to be safe in large doses:

“…Carica papaya L. leaves have been used in ethnomedicine for the treatment of fevers and cancers. Despite its benefits, very few studies on their potential toxicity have been described….The present [study] results suggest that C. papaya leaf extract at a dose up to fourteen times the levels employed in practical use in traditional medicine in Malaysia could be considered safe as a medicinal agent.”

Repeated Dose 28-Days Oral Toxicity Study of Carica papaya L. Leaf Extract in Sprague Dawley Rats
AUTHOR(S)Afzan, Adlin; Abdullah, Noor Rain; Halim, Siti Zaleha; Rashid, Badrul Amini; Raja Semail, Raja Hazlini; Abdullah, Noordini; Jantan, Ibrahim; Muhammad, Hussin; Ismail, Zakiah

April 2012

Molecules;Apr2012, Vol. 17 Issue 4, p4326

http://connection.ebscohost.com/c/articles/75144876/repeated-dose-28-days-oral-toxicity-study-carica-papaya-l-leaf-extract-sprague-dawley-rats