Papaya Leaf Increases Platelet Count and Red Blood Cell Count in Sri Lankan Study

Sri Lankan study published this year in the Asian Journal of Tropical Biomedicine reached this conclusion:

Fresh C. papaya leaf extract significantly increased the platelet and RBC counts in the test group as compared to controls. Therefore, it is very important to identify those chemicals of C. papaya leaves as it can be recommended to be used as a medication to boost thrombopoiesis and erythropoiesis in humans and in animals.

Does Carica papaya leaf-extract increase the platelet count? An experimental study in a murine model
Sinhalagoda Lekamlage Chandi Asoka

Dharmarathna1, Susiji Wickramasinghe2*, Roshitha Nilmini Waduge3, Rajapakse Peramune Veddikkarage Jayanthe Rajapakse1, Senanayake Abeysinghe Mudiyanselage Kularatne4
1Department of Pathobiology, Faculty of Veterinary Medicine and Animal Science, University of Peradeniya, Sri Lanka 2Department of Parasitology, Faculty of Medicine, University of Peradeniya, Sri Lanka
3Department of Pathology, Faculty of Medicine, University of Peradeniya, Sri Lanka
4Department of Medicine, Faculty of Medicine, University of Peradeniya, Sri Lanka

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757281/pdf/apjtb-03-09-720.pdf

PEER REVIEW
Siti Zaleha Halim, Herbal Medicine Research Center, Institute for Medical Research, Jalan Pahang 50588, Kuala Lumpur, Malaysia.

Comments
This is a interesting study of the efferct of C. papaya leaves extract on the haematological and biochemical parameters in a murine model. The findings are impressive and useful for continuous study related to C. papaya. C. papaya leaf could be an alternative to treat dengue and malaria fever instead of prescription drugs.

Peer reviewer
Tel: +603-26162633
Fax: +603 26934114
E-mail: ctzaleha.h2@gmail.com

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For ITP Drink Papaya Leaf Tea

“ITP, Idiopathic thrombocytopenic purpura is a bleeding disorder in which the immune system destroys platelets, which are necessary for normal blood clotting. Persons with the disease have too few platelets in the blood.

ITP is sometimes called immune thrombocytopenic purpura.”
-from MedlinePlus

The International Council on Infectious Diseases published a trial on Dengue patients (a similar platelet disorder) and tested with 5ml of papaya leaf extract per day on the subjects.

http://www.xcdsystem.com/icid2012/58.016.html

This amount of 5ml (less than a tablespoon) did not seem to have a significant effect on patients in this study. Ironically, the ethno medicine practiced around the world requires significantly more papaya leaf tea or extract per day and multiple times per day.

The study below finds papaya leaf effective against low platelet counts:

“Dengue virus, the main cause of dengue fever induces bone marrow suppression. Since bone marrow is the manufacturing center of blood cells, its suppression causes deficiency of blood cells leading to low platelet count. Anaemia and spontaneous severe bleeding are the other consequences of bone marrow suppression. Dengue virus can bind to human platelets in presence of virus specific antibody and cause immune mediated clearance of platelets[7]. Spontaneous aggregation of platelets to vascular endothelial cell pre-infected by virus induces aggregation, lysis and platelet destruction. Anti-platelet antibodies
generated after dengue virus infection causes destruction of platelets. Moreover, dengue virus causes platelet reduction and vascular alteration which is the principal factor causing haemorrhagic problems[8].
Vinca-alkaloids have been proven effective against anti-platelet macrophages in patients suffering from Idiopathic Thrombocytopenic Purpura (ITP)[9]. The saponins in Panax notoginseng have been shown to reduce platlet adhesion and aggregation, prevent thrombosis and improve microcirculation[7]. Carica papaya leaves contain various phytoconstituents like saponins, tannins, cardiac glycosides and alkaloids.

The alkaloids present include carpaine, pseudocarpaine and dehydrocarpaine I and II. These constituents can act on the bone marrow, prevent its destruction and enhance its ability to produce platelets. Moreover, it can also prevent platelet destruction in the blood and thereby increase the life of the platelet in circulation.”

The Journal of Pharmacognosy and Phytochemistry
Vol. 1 No. 5 2013 http://www.phytojournal.com Page | 59
http://phytojournal.com/vol1Issue5/Issue_jan_2013/11.1.pdf

Cancer-Related Low Platelet Count Improved with Papaya Leaf

Papaya leaf has shown to increase platelet count. The Platelet Disorder Support Organization (www.pdso.org) provides the following information:

Low Platelets Associated with Cancer:

Chemotherapy
for many types of cancer can damage the bone marrow and result in a low platelet count. However, there are some cancers that have a more direct association with thrombocytopenia due to bone marrow involvement, compromised immune system, or an enlarged spleen. Someone with cancer usually has other symptoms in addition to low platelets.

Myelodysplastic Syndrome (MDS)
Blood cells are produced in the bone marrow. In MDS the bone marrow is damaged and blood cell production is impaired, including platelets. The disease can transform into acute myelogenous leukemia (AML)
http://www.mds-foundation.org
http://www.ncbi.nlm.nih.gov/pubmed/21575929

Chronic Lymphocytic Leukemia (CLL)
In CLL there is a gradual increase in the B-cells, a type of white blood cell, and eventually bone marrow failure. You can get ITP in addition to CLL
http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001559/
http://www.ncbi.nlm.nih.gov/pubmed/16616070

CD8 T-lymphocyte large granular lymphocytic leukemia (LGL)
This diseases is a rare form of leukemia characterized by abnormal CD8+ T cells, a type of white blood cell.
http://www.ncbi.nlm.nih.gov/pubmed/17915315
http://www.ncbi.nlm.nih.gov/pubmed/11835350
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Refer to the following study related to low platelet count (specifically Dengue) and papaya leaf:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3614241/?report=classic