Papaya Leaf Slows Free Radical Destruction that Causes Aging and Cancer

We have published research articles that show the healing effect of papaya leaf on the liver. But this study explains how this action also has anti-aging and anti-cancer effects:

From the International Journal of Pharmacy

“…In general up on entry of any foreign particle enters in to our body. Free radicals can be generated, which is based on the size of the foreign particle or physico chemical characteristics of that foreign particle (1). The free radicals are not inactivated; their chemical reactivity can damage all cellular macromolecules including proteins, carbohydrates, lipids and nucleic acids. Their destructive effect on protein may play a role in the causation of diseases, like cataracts. Free radical damage to DNA is also implicated in the causation of cancer and its effect on LDL cholesterol is very likely responsible for heart disease. Free radicals are also responsible for ageing (2).
Iron over load causes liver toxicity by producing hydroxyl radicals by promoting Fenton reaction(3). Free radicals also can be able to cause various
diseases like neurodegenerative diseases (4), cardio vascular diseases (5), cancer etc. So the work started because of these serious effects up on the free radical generation, expecting that Herbal medicines have been used able to generate antioxidants, which can be provide balance between free radical generation and anti-oxidant levels or those anti-oxidants prevents the liver damage and gastric ulceration caused by free radicals….
In present study the antioxidant activity of aqueous extract of leaf of Carica papaya was found. From the study it was also found to decrease lipid peroxidation and significant increase in catalase, glutathione and protein with the aqueous extract of leaf of Carica papaya in dose dependant manner. Literature regarding phytoconstituents shows that aqueous extract of leaf of Carica papaya contains Alkaloids Carpain, Pseudo carpain, and dehydro carpaine I & II, Choline, Caproside, Vitamin C & E. Since all these constituents are found in the leaf of this plant it is possible that these constituents may be implicated in antioxidant activity of the species. Therefore, it was concluded that the aqueous extract of the leaf of Carica papaya possess antioxidant principles and has free radical scavenging activity.
The result have shown that the aqueous extract of the leaf of Carica papaya possesses antioxidant properties, supported by the decrease in lipid peroxidation and increase in the reduced glutathione and catalase activity in in vivo method. The in vivo antioxidant activities have been supported by its free radical scavenging activities in in-vitro method. Such antioxidant activity of Carica papaya might be responsible for its importance in traditional medicine for the treatment of various disorders. The present study opens many new areas of research work. This work can be continued in the future to study and confirm liver protective activity in different experimental models and also to isolate, identify, characterize and standardize the active principle(s) that are responsible for this activity.”

Balakrishna V*, Srikanth G, Ajay kumar Sarabu, Thippani Maneshwar
Department of Pharmacology, Vaageswari College of Pharamacy, Karimnagar, Andhra Pradesh, India
International Journal of Pharmacy
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Papaya Leaf Tea for Liver Disease

“Liver disease is the major cause of death worldwide. It ranks ninth in overall causes of death in the U.S. [1] and is the fifth ‘big killer’ in England & Wales. In India too, liver diseases are responsible for lakhs of deaths each year and is rather the only major cause of death still increasing year-on-year. Amongst the different types of liver diseases, alcoholic liver disease (ALD) is the leading cause of morbidity and mortality in the world. In an assessment by the WHO in 2005, 4% of the burden of the disease and 3.2% of all deaths globally were attributable to alcohol. The burden of alcohol-related disease is highest in the developed world, where it may account for as much as 9.2% of all disability-adjusted life years [2]. Even in the developing regions of the world, alcohol accounts for a major portion of global disease burden, and is projected to take on increasing importance in those regions over time [3]…. The available therapeutic interventions for liver diseases, which include drugs like steroids, anti-cytokines, colchicine or supplementation with calorie rich diet or a precursor of glutathione, S-adenosyl L-methionine (SAMe) have not been able to show convincing benefit in humans and also suffer from several side effects. Thus herbal medicines have an important role to play in the treatment of liver disorders considering their efficacy, safety and lesser side effects….The study thus concludes that the leaves of Carica papaya possess hepatoprotective activity, which may be partly due to its antioxidant effect. It also suggests that Carica papaya leaves are a promising candidate for the development of phytomedicine and can be used in herbal formulations alone or in combination with other hepatoprotective drugs (to provide a synergistic effect) for the treatment of liver ailments. Further, studies in humans are needed in this direction to prove its clinical utility.”

British Journal of Pharmaceutical Research 3(4): 648-661, 2013
SCIENCEDOMAIN international
Ameliorative Effect of Leaves of Carica papaya in Ethanol and Antitubercular Drug Induced Hepatotoxicity
Aashish Pandit1, Tarun Sachdeva1 and Pallavi Bafna1*
1Department of Pharmacology, Rayat Institute of Pharmacy, Railmajra, Punjab, India.

Ina conclusion of a study on the leaf’s effect on hypoglycemia, the scientists conclude the study with this statement:

“…the leaf positively affected integrity and function of both liver and pancreas.”

Hypoglycemic effect of Carica papaya leaves in streptozotocin-induced diabetic rats
Isela Esther Juárez-Rojop1*, Juan C Díaz-Zagoya2, Jorge L Ble-Castillo1, Pedro H Miranda-Osorio1, Andrés E Castell-Rodríguez2, Carlos A Tovilla-Zárate4, Arturo Rodríguez-Hernández3, Hidemi Aguilar-Mariscal1, Teresa Ramón-Frías4 and Deysi Y Bermúdez-Ocaña4

Juárez-Rojop et al. BMC Complementary and Alternative Medicine 2012, 12:236

Nigerian Studies Show Protective Effect of Papaya Leaf on the Liver

This study shows promise that papaya leaf tea may be a protective and healing agent for diseases of the liver.

Researchers Minari and Bamisaye published in the Journal of Medicinal Plant Research:

“The hepatoprotective properties of methanolic extract of Carica papaya stalk on albino rat were evaluated. To achieve this, the phytochemical screening of the extract was carried out and carbon tetrachloride (CCl4) (i.p) was injected into albino rats to liver damage. The rats were simultaneously given oral doses of 20, 40, 60, 80 and 100 mg/kg (p.o) of methanolic extract of C. papaya stalk. The effects of this extract on liver total protein concentration, alanine aminotransferase, aspartate aminotranferase, and gamma-glutamyltransferase activities of the rats were studied after 7 days period of the experiment. Administration of CCl4 alone to rats significantly increased (p < 0.05) total protein concentration and the activities of the transferases studied in the serum when compared with controls which received distilled water (p.o). Simultaneous treatment of CCl4 injection and oral administration of different doses of the C. papaya stalk extract significantly reduced (p < 0.05) total protein concentration, activities of liver transferases studied. However, the lowest significant reduction (p < 0.05) of total protein concentration and the transferases was observed with simultaneous administration of 100 mg/kg of the extract on the rats. This study suggests that the extract of C. papaya stalk possesses the phytochemicals with antioxidant properties which might be responsible for it capacity to protect the liver from oxidative damage.”