Figure is [enzyme] Papain Structure (Huet J et al., 2006)

“…Phytochemicals in c. Papaya with Reported Anticancer Activities
Carica papaya contains a broad spectrum of Phytochemicals including enzymes (in the latex), Carotenoids (in fruits and seeds), alkaloids (in leaves), phenolics (in fruits, leaves, and shoots), glucosinolate (in seeds and fruits) (Krishna et al., 2008; Parle et al., 2011). Some important Phytochemicals found in C. papaya are Lycopene, Betacarotinoid, Benzylisothyocynate, Betacryptoxanthin, Benzylglucosinolate, chlorogenic acid, caffeic acid, protocatachuic acid, Quercetin, Among more than 5000 compounds from plants that have been identified to be associated with anticancer properties (Huang et al., 2009), three groups of bioactive compounds-phenolics, Carotenoids, and glucosinolate-have attracted considerable interest in anticancer studies. Pure compounds of these three groups have been extensively researched in vivo and in vitro studies on many types of cell lines for their potential effects in cancer treatment and prevention. These bio actives act via multiple mechanisms such as cancer cell signalling, proliferation, apoptosis, migration, invasion, as well as angiogenesis and carcinogen elimination (Huang et al., 2009; Zhang et al.., 2004; Thornalley et al., 2002; Nakamura et al., 2006; Wu et al., 2009; Navarro et al., 2011; Wahle et al., 2011; Soobrattee et al.., 2006; Tanaka et al., 2012; Breemen et al., 2008) to exhibit in vitro and in vivo anticancer activities.”


CIBTech Journal of Pharmaceutical Sciences ISSN: 2319–3891 (Online)
An Online International Journal Available at http://www.cibtech.org/cjps.htm 2013 Vol.2 (1) January-March, pp.25-34/Sheikh and Krishnamurthy
Review Article
*Sheikh Fauziya and R Krishnamurthy
CG Bhakta Institute of Biotechnology, Uka Tarsadia University, Maliba Campus Bardoli, Dist. Surat, Gujarat, India-394350
*Author for Correspondence

Asian Pacific Journal of Tropical Disease Publishes Study on Papaya Leaves: Suggest Anti-Cancer Drug


Journal published study that suggests that due to annonaceous acetogenins, papaya leaf biomass could be used for an anti-cancer drug.

Annonaceous acetogenins are similar to long-chain fatty acids. JL McLaughlin of Purdue University also has produced research claiming that it is the effect of the annonaceous acetogenins in the papaya leaf that have effect against cancer. He claims, [in the papaya leaf] “….powerful cytotoxicity, in vivo antitumor, pesticidal, antimalarial, anthelmintic, piscicidal, antiviral, and antimicrobial effects indicated a myriad of potentially useful applications. ”



An Alternative Perspective on Cancer

An Alternative Perspective on Cancer and the Immune System:

What is Cancer and How Does It Attack the Body?

-“Immunition Report”, Frank M. Jordan Volume III, Number 5

“The most common cause of death in the U.S. is cancer, accounting currently for 1 in 2 mortalities… Billions spent in research have not dented death statistics.

Cancer is any of a group of more than 200 diseases with symptoms of unrestrained growth of cells in one of the body organs or tissues. The most common form of cancer is carcinoma which originates in the skin or in the glandular tissue such as the breast or prostate gland. Another form of cancer, sarcoma, affects connective and supportive tissue such as bone, muscle, cartilage and fat. Melanomas are more serious, often, but not always, manifested as skin cancers. Lymphomas affect the lymphatic system throughout the body, while leukemias are cancers of the blood-forming organs.

Did you know you probably get cancer up to six times per year, but your immune system when at peak recognizes, attacks and destroys the cancerous cells before potentially deadly growth and multiplication!

Prevention is promoted with proper lifestyle including nutrition, standard and so-called alternative treatments including nutritional supplements. Permissible treatments logically should be expanded to include these same factors proven safe and effective, in addition to the standards of surgery, chemotherapy and radiation to place the patient’s welfare as the number one priority instead of profits and exclusivity.

When not destroyed immediately by your immune system, the new cancer cells avoid the usual controls on growth and multiplication in normal cells. The growth begins when the genes controlling cell growth and multiplication called oncogenes are transformed by cancer-causing agents named carcinogens into cancer cells.

Normal cells can have a malignant change to become a cancer infested cell. These small groups of abnormal cancer cells divide more rapidly than the normal surrounding cells. The fast multiplication results in invasion and destruction of normal body cells. The abnormal cells usually show a lack of “differentiation,” meaning they no longer perform their unique roll as normal cells in maintaining good health. Cancerous cells act as uncontrollable parasites, consuming needed nutrients while contributing nothing except malnutrition.

If not killed and removed, these cancerous cells can then spread (metastasize) via the bloodstream and lymphatic system to other parts of the body from their original site and potentially be fatal if causing organs to fail.

Your immune response is critical to beating or controlling cancer because cancerous tumors develop and multiply when the white immune cells fail to recognize, respond and kill the cancerous cell invaders. If not at peak, the immune response often fails to respond timely when overwhelmed due to the massive number of corrupted cancer cells that have multiplied rapidly when undetected and unchecked.

What Do Cancer and Fetal Development Cells Have in Common?

Cancer cells are similar to fetal development cells called trophoblast that are responsible for the enormous growth from inception to day 55-60. The pancreas then starts working, secreting an enzyme called chymotrypsin. Trophoblast cells are negatively charged with a protein coating that repels white immune cells to prevent your immune system from destroying the developing child.

At the proper time, chymotrypsin destroys the protein coating, the abnormally fast growth ceases and normal baby development continues. Almost all cancer cells unfortunately exhibit this same protein coating with the negative charge that repels immune cells. If pancreatic enzyme production is impaired, as in diabetes or from fungal infections, cancer cells hide from the immune cells thus avoiding attack and removal. Supplemental proteolytic enzymes are believed to be beneficial nutritional supplements in cases of pancreatic enzyme production.

A Healthy Versus Suppressed Immune Response

When your immune response is in peak condition, it is better able to recognize the cancerous cells quickly and respond to kill the health invaders rapidly in most instances. A suppressed or impaired immune response exposes a body to both development and spread (metastasis) of too-often deadly cancer cells in the body.

We are often our own worst enemies instead of helping in our body war against cancer. Diets are poor, we exercise little, rest inadequately and stress too much. Our immune systems are suppressed with excessive free radicals (rogue molecules that damage cells similar to sparking wires) and nutrient delivery is impaired due to high toxicity and high acidity in the body.

Free radicals arrive in toxins entering our systems, including 4,000 legal food additives. Sugar is the food of cancer with a cancer cell having 92 sugar receptors compared to a normal cell with 4! Cancer could be increasing because we now eat an average of 150 lbs a year of sugar compared to only 5 lbs in 1904! Cancer also thrives in an acidic rather than balanced body. Keeping the pH balanced is essential to fighting cancer.

Add polluted air, most tap water; in addition to pathogens such as parasites, fungi, bacteria and viruses. Mix in heavy metals, particularly with dental work and toxic chemicals. Genetic factors damaging cellular DNA (together with caffeine) join immunological weaknesses in certain cancer types and cases.

Present Cancer Treatments – The Facts

The most common treatment in 50% of cancer cases is chemotherapy, but success unfortunately occurs in too few cases (2 to 25%), such as ovarian cancer in women, testicular cancer in men and Duke’s C, a form of colon cancer. Chemo too often shrinks tumor size but does not kill all the cancer cells while damaging other cells. How many cancer patients have heard the words, “We got it all but we want to do preventive chemotherapy to be sure!” Because chemotherapy ingredients often attempt to curtail rapidly multiplying cancer cells, other rapidly multiplying cells such as hair, nails and skin can also be negatively effected (hair loss, pallor, etc.) by multiple treatments.

Dr. Ralph Moss, author of Questioning Chemotherapy, explains most people confuse decreased tumor size with disappearance of disease. The association appears logical, but no known significant proof exists to support the connection. Statistics too often are skewed due to study drop-outs, age limitations on participants and even statistical definitions such as “cure” means an absence of cancer for a five year period from diagnosis.

Even more disturbing, chemotherapy and radiation are recognized carcinogens that can cause rather than cure cancer while increasing dangerous excess acidity which promotes cancer growth. Because of toxicity, chemotherapy and radiation are always spaced out time-wise between treatments, allowing the cancer cells often to multiply rapidly in the interim. Non-toxic alternative treatments do not require time spacing.

The Biopsy Dilemma in Metastasis

An irony can occur during a biopsy of an encapsulated tumor believed to be cancerous because of potential tumor perforation. If the biopsy procedure perforates a malignant tumor, cancer cells are released into the blood stream to metastasize that are otherwise contained. Sadly, a biopsy that can cause metastasis is often performed for legal reasons just before a surgery scheduled to prevent metastasis! If scheduled for cancer tumor surgery, ask for straight answers about the biopsy status and risk before the surgery.

Alternative therapies are often criticized for not being tested according to scientific standards, but many “accepted” treatments, including chemotherapy and radiation, have very limited success, but are both patentable and profitable. In fact, a “cure” is now defined as being alive 5 years after diagnosis – not cured, with present “cure rates” deceptively including non-life-threatening forms of cancer such as simple skin cancers.

This makes cure rates of 50% or more knowingly deceptive by the cancer and pharmaceutical industry due to deceptive statistic practices. This is a moral crime against the victims of cancer in giving knowingly unrealistic “cure” rates. Shouldn’t natural alternatives that have minimal toxic effects on other important functions of the body also be given research funds?

Why Don’t Pharmaceuticals Research and Promote Natural Cancer Treatments?

Alternative treatments are almost universally non-toxic, causing no harm to normal healthy cells in the body while the body is trying to recover from cancer. How can nutrition be an “alternative” treatment while injecting synthetic chemicals is mainstream? Hopefully the answer isn’t money, but the facts too often indicate otherwise. While surgery, chemotherapy and radiation target specific areas of the body, alternative treatments usually approach cancer as a holistic, or whole-body disease; while enhancing the immune response to better attack cancer cells throughout the body. The holistic approach makes sense as research indicates 60-75% of patients diagnosed with cancer have cancer already metastasized.

Why won’t giant pharmaceuticals market natural and alternative cancer treatments? The current system for a cancer drug to be approved by the FDA requires $700+ million dollars and years in research and approval time. Additionally, a natural cancer treatment is not patentable; a protection needed to assure exclusivity and substantial profits for a long-time period.

Being unpatentable makes the extensive time and huge expenditure uneconomic. Unless the system is changed, a natural form of treating cancer will almost certainly never be marketed by a major pharmaceutical. Medical schools also participate in patent profits. Profits – not people – all too often come first! Interrelationships between those regulating and those manufacturing have become more prevalent and disturbing in assessing the possible abuse of objectivity, although most in the regulatory agencies are well-intended and working within a system determined too often by politicians and contributors.

Doctors – Forced Denial by the Present Medical System

Patients many times are not aware that even if their health care provider wants to try a treatment forced to be classified as alternative, in most states the doctor is not legally allowed to prescribe or even recommend anything but surgery, chemotherapy and radiation due to the rigidity of antiquated Standards of Practice or Care.

Doctors often tell patients using alternative therapies to “keep on doing what you’re doing” to avoid personal licensing problems. Are physicians being taught nutrition and other alternative applications in Medical School in a positive and sufficient manner? The answer unfortunately is no, with little change anticipated. Why can’t we use the best of all health sciences with the patient – not the dollar – as our objective in application? The reality is until sick people vote and natural ingredients can produce billions of dollars for profits and contributions, the system priorities will remain with the wrong focus – to the detriment of the cancer victim.”

I choose to publish this perspective because it explains the science of why it is a good idea to add proteolytic enzymes (like chymopapain and papain in the papaya leaf) to your body because they contribute to dissolve the protein coating (similar to chymotrypsin) around cancer cells so that your body can destroy them.


Who Is Julia Ruffin?

Who is Julia Ruffin?

Julia Ruffin Robertson was taken by cancer at age 55, and is survived by her two sisters; Jenny and Margie, three daughters; Gwenette, Virginia, and Jane; and seven grandchildren; Francis, Julia, Laurel, Owen, Nicholas, Sylvia, and Jamal.

Julia was from Laurel, a small town in Mississippi. She was named “Judy” as a child, and after raising three daughters she followed her life passion for art and returned to university and worked for her master’s degree in art history. After receiving her degree she changed her name to Julia.

Julia started a private high school near Washington, DC, and then moved with her husband, Palmer to Malawi, Africa to run a small mission college. Even after discovering her sickness with cancer she continued to help her husband in Africa until she was too sick to function. Julia returned to the states and died soon after.

Julia inspired her daughters to value motherhood, to love all forms of art, to gently work for justice in the world and to pursue solutions for good.

The Director of the project, Jill Nicole Gallo, elected that we run this project in Julia’s name. Julia, she said, is the inspiration for this Project to produce a natural product that heals cancer.

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The Julia Ruffin Project

I have been researching papaya leaf tea for six years now. The tea is safe, based on a toxicity study in 2012. The FDA rates it as GRAS (Generally Regarded as safe). The tea is used at clinics in at least fourteen countries as alternative cancer therapy.

The goal of the Julia Ruffin Project is to promote papaya leaf tea for its effect on cancers. The other goal is to research and grow young papaya leaf tea (leaves from the plant, not the tree) because the leaves have more alkaloids when they are younger and also have a much nicer taste.

The project is non-profit and we need your support. See our site


Not the Non-Information: Papaya Leaf Tea Therapy for Cancer

A well known cancer center has “not the non” information about the effect of papaya leaf tea on cancers.

See this Link

Buried under disclaimers is a set of information about the effect of papaya leaf tea on tumors and cancer.

I am impressed that this clinic even has the guts to tell the story of this tea, deep under Houdini’s disclaimers chains. I call this “not the non” information.

I don’t get why cancer patients are given “not the non” disclaimer info so much. We have clinical studies on the effect of papaya leaf tea on cancers. Why is this not big news? It is not expensive, is available, and is non-toxic. Hmmm

So for me, the blogger who writes in the interest of people with cancer who want to feel better, without disclaimer I say, TRY IT!! How many more clinical studies do you need?

Papaya Leaf Tea has Effect Against Cancer

Papaya leaf tea is used as alternative cancer therapy in fourteen countries. I have studied the science and the farming of the herb for six years. It seems odd that the large papaya fruit-bearing tree is actually classified as an herb. It seems equally odd that the young leaves of this tree make such a miraculous medicinal tea.

Scientists that have studied the anti-tumor effect of the leaves find various medical reasons that the tea has effect against cancer. One of the most well known is research by Nam Dang. I choose to stick by my favorite; that the tea has an unusual enzyme to nature called papain that breaks down and dissolves proteins. Another form of “protease” is called trypsin, and is naturally produced by our pancreas. The protease dissolves the fibrin, or protein coating around our cancer cells or running in our blood thus freeing our bodies to fight or prevent the cancer.

The leaves need to be initially heated to 150-160F degrees to activate the enzyme, therefore, a “tea”.