Pill with Papaya Leaf Extract Intended to Fight Dengue

There are a number of positive results from various clinical studies on the effect of papaya leaf juice on Dengue Fever:

1. https://clinicaltrials.gov/ct2/show/NCT02016027

2. http://ijabmr.org/article.asp?issn=2229-516X;year=2016;volume=6;issue=4;spage=249;epage=254;aulast=Charan

3. http://www.openaccessscience.com/pdf-files/vol2_4_dec2012/IJMAP_2_4_4_Carica_papaya.pdf

4. http://slctr.lk/trials/110%20%

5. http://www.jcbsonline.ac.in/Articles/12.%20Case%20report%201%20final%20print.pdf

6. Review of seven clinical studies

http://op.niscair.res.in/index.php/IJNPR/article/download/13529/969

7. https://www.worldwidejournals.com/indian-journal-of-applied-research-(IJAR)/file.php?val=October_2016_1477141322__191.pdf

And now a clinical study on Microlab’s nutraceutical pill, Caripill:

https://ayurajan.blogspot.com/2015/09/caripill-pill-with-papaya-leaf-extract.html?m=1

http://www.caripillmicro.com/assets/japi.pdf

http://www.caripillmicro.com/

The Julia Ruffin Project promotes papaya leaf for its effect on disease.

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Nine Dengue Patients Observed Recovered With Papaya Leaf

A test of the effect of papaya leaf on nine patients with Dengue Fever was published in India last Spring:

“In the present study we found the therapeutic potential of papaya leaf extract (PLE) in curing dengue infection by increasing platelet and WBC counts respectively. Ultrasonographic findings, blood reports, statistical analysis and patient’s recovery from dengue infection further supported the culinary effect of papaya leaf extract (PLE) in dengue patients. The nontoxic nature of PLE also supports its use as natural herbal remedy for dengue infection. An earlier study categorized Carica papaya leaf as non toxic (LD50 >15g per Kg body weight) (Kardono et al., 2003).”

-International Journal of Applied Biology and Pharmaceutical Technology
THERAPEUTIC POTENTIAL OF CARICA PAPAYA L. LEAF EXTRACT IN TREATMENT OF DENGUE PATIENTS
C.V.M. Naresh Kumar1,2, V. Taranath1, A. Venkatamuni3 , R. Vishnu Vardhan4, Y. Siva Prasad1, U. Ravi3 and D.V.R. Sai Gopal1,2*
1Department of Virology, College of Sciences, Sri Venkateswara University, Tirupati -517 502, Andhra Pradesh, India
2Department of Science and Technology-Promotion of University Research and Scientific Excellence Centre (DST-PURSE CENTRE), Sri Venkateswara University, Tirupati -517 502, Andhra Pradesh, India 3Vishnu Sri Hospital, Korlagunta Main Road, Tirupati -517 502, Andhra Pradesh, India 4Department of Statistics, Pondicherry University, Puducherry – 14, India *Corresponding author Email: profdvrsaigopal@gmail.com

http://www.ijabpt.org/applied-biology/therapeutic-potential-of-carica-papaya-l-leaf-extract-in-treatment-ofdengue-patients.pdf

Papaya Leaf for Dengue in Delhi

“Delhi government struggles with dengue outbreak
Extra hospital beds ordered and medical-staff leave cancelled amid warning situation in Indian capital could worsen.”
Showkat Shafi | 19 Sep 2015 10:30 GMT | Health, Dengue, India, Asia
http://www.aljazeera.com/news/2015/09/delhi-government-struggles-dengue-outbreak-150919053907482.html

A respected European Journal notes the Aryvetic approach to managing dengue fever.

Given the recommendation to treat with papaya leaf, and the abundance of this herb in India, it may be profitable to society for papaya plantations to supply hospitals in Delhi with leaves (given the reported nature of the current health crisis.)

“The juice of papaya leaf has been found to be useful in the treatment of dengue fever. A number of scientific papers have proved that papaya leaf juice is actually beneficial for the body. Few recent studies have shown the effect of papaya leaf juice in curing the dengue fever. A recent one, done on five dengue patients by Indian Institute of Forest Management in 2012, found interesting observations. Among the five patients, papaya leaf juice was found to be effective in curing dengue. The platelet count increased in all five patients within 24 hours of drinking the papaya leaf juice. All of them reported significant improvement in health.[10]
A 2009 study, done on mice in Malaysia, reported significant improvement in thrombolytic count in the group which received papaya leaf formulations compared to the control group. It seems that this bitter green juice is promising without posing any serious ill-effects.”

ejpmr, 2015,2(4), 693
EUROPEAN JOURNAL OF PHARMACEUTICAL AND MEDICAL RESEARCH
http://www.ejpmr.com
Research Article search
ISSN 3294-3211
EJPMR
“AN AYURVEDIC INSIGHT TOWARDS DENGUE FEVER”
Dr. Sumit Srivastava*
Associate Professor, Dept. of Rog-nidan, Shri Dhanwantry Ayurvedic College, Chandigarh.
Article Received on 18/05/2015 Article Revised on 12/06/2015 Article Accepted on 04/07/2015

http://archive.indianexpress.com/news/bitter-treatment-papaya-leaves-can-fight-dengue- cancer/1178680/.

The Julia Ruffin Project promotes and researches papaya leaf for its effect on cancer and disease.

Pakistan Researchers Prove Effect of Papaya Leaf on Dengue Infected Man

-http://www.jpma.org.pk/full_article_text.php?article_id=6137

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March, 2014

Effects of papaya leaves on thrombocyte counts in dengue – a case report
Pages with reference to book, From 364 To 366
Osama Siddique, Ayesha Sundus ( Student, Dow University of Health Sciences, Karachi. )
Mohammad Faisal Ibrahim ( Civil Hospital Karachi. )

Introduction
Carica papaya L. is the only species within the Caricaceae genus, and the palm-like tree has segmented leaves, yellow flowers and large black seeded yellow to orange fruits.1 C. papaya L. fruit juice and leaves extracts have demonstrated anti-cancer,2 anti-oxidative,3 anti-inflammatory,4 anti-bacterial,5 nephro-protective,6 hepato-protective7 activity against toxins, hypoglycaemic, hypolipidaemic effects8 and anti-sickling properties in sickle cell disease.9
Dengue fever (flaviviridae family of viruses) is an arthropod-borne disease carried by Aedes ayegypti with four different serotypes 1, 2, 3 and 4.10 Dengue fever cases have been on the rise in Pakistan and other developing countries. It is estimated that there are between 50 and 100 million cases of dengue fever (DF) and about 500,000 cases of dengue haemorrhagic fever (DHF) each year which require hospitalisation.10 There is no known anti-viral chemotherapy for DF yet. Many vaccine trials have been done, but none has produced a satisfactory outcome.10 Management includes supportive measures like anti-pyretic, hydration, blood and blood products and pain killers. Infection induces a life-long immunity to that particular serotype, but secondary infection with another serotype is dangerous and life-threatening due to higher risks of DHF.11 The only way to prevent dengue virus acquisition is to avoid being bitten by a vector mosquito.10
With such high rates of incidence and mortality it would be useful to have a regimen improving the outcome of the disease. Investigating the effect of papaya leaves on the platelets can help our physicians in helping patients with diseases like DF where the platelets are the major cause of complications and mortality. Here we present a DF case who responded positively to the administration of papaya leaves extract.

Quaid-i-Azam University, Islamabad Study Effect of Papaya Leaves on Dengue Man

Scientists from Quaid-i-Azam University, Islamabad tested papaya leaf cure on a 45 year old man with dengue fever.

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Document heading doi:10.1016/S2221-1691(11)60055-5
Dengue fever treatment with Carica papaya leaves extracts
Nisar Ahmad1, 2*, Hina Fazal 1, 3, Muhammad Ayaz4, Bilal Haider Abbasi1, Ijaz Mohammad5, Lubna Fazal5
1Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad 45320, Pakistan
2Nuclear Institute for Food and Agriculture (NIFA) Tarnab, Peshawar 25000, Pakistan
3Pakistan Council of Scientific and Industrial Research (PCSIR) Laboratories Complex, Peshawar 25000, Pakistan 4Department of Environmental Sciences, University of Peshawar, Peshawar 25000, Pakistan
5Postgraduate Medical Institute (PGMI), Lady Reading Hospital, Peshawar 25000, Pakistan
ARTICLE INFO
Received 28 February 2011
Received in revised form 20 March 2011 Accepted 6 April 2011
Available online 30 April 2011
ABSTRACT
The main objective of the current study is to investigate the potential of Carica papaya leaves extracts against Dengue fever in 45 year old patient bitten by carrier mosquitoes. For the treatment of Dengue fever the extract was prepared in water. 25 mL of aqueous extract of C. papaya leaves was administered to patient infected with Dengue fever twice daily i.e. morning and evening for five consecutive days. Before the extract administration the blood samples from patient were analyzed. Platelets count (PLT), White Blood Cells (WBC) and Neutrophils (NEUT) decreased from 176暳103/毺L, 8.10暳103/毺L, 84.0% to 55暳103/毺L, 3.7暳103/毺L and 46.0%. Subsequently, the blood samples were rechecked after the administration of leaves extract. It was observed that the PLT count increased from 55暳103/毺L to 168暳103/毺L, WBC from 3.7暳103/毺L to 7.7暳103/毺L and NEUT from 46.0% to 78.3%. From the patient feelings and blood reports it showed that Carica papaya leaves aqueous extract exhibited potential activity against Dengue fever. Furthermore, the different parts of this valuable specie can be further used as a strong natural candidate against viral diseases.

-The Asian Journal of Tropical Biomedicine
http://apjtb.com/zz/aug/18.pdf

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State of Emergency in Honduras over Dengue: Take Papaya Leaf

South Americans are really needing to hear about the effect of papaya leaf on Dengue Fever. They are currently facing an epidemic that has called their government to issue a state of emergency. The fever is charted to spread out to other South American countries. Papaya is native to South America so this cure is in their back yard. The leaves can be dried in the sun, crushed, and then brewed as a tea for the dengue patient. Papaya leaf tea has shown to very quickly restore red blood cell count and almost miraculously bring healing to the liver.

Honduras faces deadly dengue fever epidemic
Aug 27, 2013 by John Sevigny
World

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In the wake of 12,000 reported cases of mosquito-borne dengue fever and at least 19 deaths from the disease, Honduran officials have declared a state of emergency as the rainy season looms in that Central American country.

Read more: http://m.digitaljournal.com/article/357218#ixzz2f3UMKuJQ

Honduras enfrenta mortal epidemia de dengue

A raíz de 12.000 casos de dengue transmitida por mosquitos y por lo menos 19 muertes por la enfermedad, las autoridades hondureñas han declarado el estado de emergencia ya que la temporada de lluvias se cierne en ese país centroamericano.

Read more: http://m.digitaljournal.com/article/357218#ixzz2f3UMKuJQ

Centroamericano son realmente necesitan escuchar sobre el efecto de hoja de papaya de Dengue Fever. En la actualidad se enfrentan a una epidemia que ha llamado a su gobierno para emitir el estado de emergencia. La fiebre está trazada a extenderse a otros países de América del Sur. La papaya es nativa de América del Sur por lo que este cura es en su patio trasero. Las hojas se pueden secar en el sol, aplastados, y luego elaboradas en forma de té para el paciente dengue. Té de hoja de papaya ha demostrado para restaurar muy rápidamente recuento de glóbulos rojos y casi milagrosamente traer sanidad para el hígado.

Dr Sanath Hettige Sees Urgency in Promoting the Healing Effects of Papaya Leaf Tea

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“a delay in formal research and publication may result in many deaths if we were to wait for results of a study without making information available to patients during the present epidemic.” – Dr Sanath Hettige

From the Sri-Lankan News, Sunday Observer
Sunday, 25 July 2010

Papaya leaf extract – wonder drug for dengue patients?
By C.I. Munasinghe
While the dreaded disease, dengue has reached epidemic proportions with a countless number of patients infected by it islandwide and the death toll mounting unabated, creating a national crisis – a cure for this dreaded disease however is still in wanting.

Dr. Sanath Hettige, an MBBS doctor – a consultant family physician-has affirmed that papaya leaf extract has definite beneficial effects on dengue patients. It prevents dengue patients from going in to dengue haemorrhagic state, he says.

The first ever scientific bio-medical study conducted to discover the salutary effects of Carcia papaya leaf extracts in patients suffering from dengue fever by Dr. Hettige was reported in the Sri Lanka Family Physician magazine in his article on the said subject in 2008.

The report further states, “The pilot study has shown the effects of papaya leaf juice in dengue patients of elevating the total white cell counts, platelet counts and recovery without hospital admission.”

This was followed up in the IMPA newsletter of June 2009 volume 14, issue 6, in which he has written on his preliminary observations of his study to his colleagues for their consideration with the view to establishing a scientifically sound study. In the same article he has also said that “a delay in formal research and publication may result in many deaths if we were to wait for results of a study without making information available to patients during the present epidemic.”

Dr. Hettige’s latest research on randomised controlled clinical trial that is on going with more than 70 dengue patients including children has found that all patients who consumed papaya leaf extracts recovered fully with no hospital admission. The results had been highly significant when compared to the control group who did not consume papaya leaf extract. Meanwhile Dr. Hettige has submitted an application for patent rights for its use and has received a patent number, but is awaiting approval.

The Sunday Observer met Dr. Hettige to find out more details of his decision to reveal his findings related to this wonder juice to the public, the details on how he initially started his research and how this papaya leaf extract could be administered to a patient.

“I have found this method of treatment for dengue patients to be very effective. Although the study is not fully completed, I decided to release this information at a time dengue has reached a national crisis situation and the public would benefit from this information”.

Q: What prompted you to initially do research on this disease?

A; It was in fact my wife, a Senior Medical Officer at the Intensive Care Unit, Sri Jayewardenepura Hospital, who would see the helpless dengue patients among many others, coming in to her unit and she would call me to inform of their suffering, and how most often than not the patients succumbed to this infection. She would constantly ask if there is nothing we could do. This prompted me to do something about it.

Q: How did you first start off your research?

A: Initially, I had a number of patients – relatives of those who work for me, friends and relatives infected by dengue who gave their consent to carry out the research on them. The pilot study consisted of 24 patients in total. Twelve who were given the juice and 12 as controls (who were not given the juice). We found that the 12 who consumed the papaya extract had good results. It was significant to observe that the platelet count increased in all 12 patients with two doses of papaya leaf juice and they all recovered with no hospital admissions, as per the details given in the pilot study that was published.

Preparation
Q; How is the papaya fruit leaf juice prepared for consumption for the purpose of treatment of dengue?

A: Leaves from a fruit-bearing tree can be taken (the Red Lady Papaya variety which is more effective), it has to be washed with clean water and then crushed in a wooden pestle without water or salt. The crushed leaves are then to be squeezed by hand to extract the juice which can be consumed fresh once again, without water, salt or sugar.

Q; What is the quantity of the leaf extract that has to be taken for an adult and child respectively?

A: A quantity of 10 ml is prescribed for adults twice a day and 5ml twice a day for children aged between five and 12 years.

Q: Could you give the scientific explanation as to how papaya leaf extract is effective in curing dengue?

A: It does three main services – the leaf extract increases the white blood cells and blood platelets and normalises the clotting profile which are the main aspects affected when infected with dengue. The most important factor is that it improves liver function too. The juice helps repair the damage caused to liver cells by dengue fever.

Q: At what stage should a patient consume papaya leaf extract?

A: It is best to consume it in the early stages of dengue haemorrhagic fever when the platelet count (PLT) drops below 150000 cu mm or when the packed cell volume is increased by 10 percent even though the World Health Organization (WHO) criteria to diagnose DHF is PLT of 100000 cu mm or Packed cell volume increase by 20 percent.

Papaya leaf juice has definite beneficial effects even when given to patients with very low platelet counts, altered clotting profiles and bleeding tendencies. But in the final stages of dengue, where multi-organ failure has set in, the beneficial effects are minimal. This is why the patients are advised to take papaya leaf juice early. When it is given early to patients, they recover fast, thus preventing the need for hospital admission. Most importantly, patients who have been identified as dengue-infected should first seek medical attention and take the juice along with the prescribed medication.

-http://www.sundayobserver.lk/2001/pix/PrintPage.asp?REF=/2010/07/25/fea02.asp

Thanks to Mr Martinez for a lead to this story.