2016 Study on Fermented Papaya in form of FPP Indicates Cancer Effect

FPP is a registered trademark for a natural preparation of fermented green papaya that has been under intense study for years related to its effect on cancer and viruses.

The study below, published this year by the Asian Pacific Journal of Cancer Prevention, discusses the amazing effect of fermented papaya taken orally, on tumors.

The fermenting of papaya leaf is part of the ancient Aryuvetic medicine. The papaya leaf has some similar enzymes that may account for the medicinal-related properties also found in the green, unripe papaya used as the base for FPP. Fermented products have shown to be more easily absorbed by the body.

Anti-Tumor and Immunoregulatory Effects of Fermented Papaya Preparation (FPP: SAIDO-PS501)

Shinki Murakami1*, Shingo Eikawa2, Savas Kaya2, Mitsuko Imao1, Toshiki Aji2

 Asian Pac J Cancer Prev, 17 (7), 3077-3084

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Scientists published papaya leaf tea as invention to combat cancer

Filed in 2005 by Nam Dang and Chikao Morimoto to the US Patent Office, the portion of the application below offers a view from the scientists as to the way to brew and take the tea for effect on more than ten types of cancer. 

The indication from the application looks like it is “preferable” to take one half to three cups per day of papaya leaf tea, approximately, for one to three months to combat the listed cancers.

…”The present invention’s brew/extract components, prepared from, for example, a papaya leaf, or fractionated components thereof, are effective in the prevention or treatment of stomach cancer, lung cancer, pancreatic cancer, liver cancer, colon cancer, uterine cancer, ovarian cancer, neuroblastoma or other solid cancers, or lymphoma, leukemia or other blood cancers. In a preferred embodiment, treatment is administered to those suffering from a disease. In another embodiment, treatment is administered as prophylaxis. The dose of the brew/extract components or fractionated components thereof to be administered will depend on the dosage form, symptoms of the subject, type of cancer or the like. However, for example, when the brew/extract is taken, it is normally preferable to take an amount of 100 ml to 750 ml per day, every day for between one month and three months. When the fractionated components are taken, it is preferable to take an amount of 10 ml to 200 ml per day, every day for between one month and three months.”

Section [0011]

Compositions for Cancer Prevention, Treatment, or Amelioration Comprising Papaya Extract 

US 20080069907 A1

The scientists, along with Noriko Otsuki, also published in the Journal of Ethnopharmocology the following study in 2010, “Aqueous extract of Carica papaya leaves exhibits anti-tumor activity and immunomodulatory effects” which revealed in detail their science behind the tea.

This article is not intended to prescribe the tea, only to publish information related that is available by academics who study papaya leaf.

International Pharmaceutical Journal: Papaya Leaf Cancer Prevention Reviewed in Saudi Arabia

This research paper just published this year, 2016, gave a concise five page summary of papaya and its effect on disease. Dr Dang’s original research at the University of Florida was referenced related to papaya leaf and its effect on cancer.

“Plants products or constituent of the plants shows therapeutics role in the cancer prevention and treatment [37]. In this regards, papaya and their valuable constituents have a significant role in the cancer management. An important study examined the effect of aqueous- extracted C. papaya leaf fraction on the growth of various tumor cell lines and on the anti-tumor effect of human lymphocytes and results showed that growth inhibitory activity of the CP extract on tumor cell lines derived from cervical carcinoma (Hela), breast adenocarcinoma (MCF-7), hepatocellular carcinoma (HepG2), lung adenocarcinoma (PC14), pancreatic epithelioid carcinoma (Panc-1), and mesothelioma (H2452) in a dose-dependent manner. In addition, CP extract inhibited the proliferative responses of haematopoietic cell lines, including T-cell lymphoma (Jurkat), plasma cell leukemia (ARH77), Burkitt’s lymphoma a (Raji), and anaplastic large cell lymphoma (Karpas-299) [38].”

POTENTIAL ROLE OF CARICA PAPAYA AND THEIR ACTIVE CONSTITUENTS IN THE PREVENTION AND TREATMENT OF DISEASES
ARSHAD H RAHMANI1, YOUSEF H ALDEBASI2
1Department of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Saudi Arabia, 2Department of Optometry, College of Applied Medical Sciences, Qassim University, Saudi Arabia
Email: rehmani.arshad@gmail.com

http://innovareacademics.in/journals/index.php/ijpps/article/download/8891/pdf

Papaya Leaf Shows Effect on Skin Cancer in Lab

2016/01/img_1922.png
A very special publication on Christmas Eve, 2015 shows the hard work in Australia to prove the inhibitive effect of papaya leaf on the second most common type of skin cancer, squamous cells.

” In this study, we investigated the in vitro cytotoxicity of aqueous and ethanolic extracts of Carica papaya leaves on the human oral squamous cell carcinoma SCC25 cell line in parallel with non-cancerous human keratinocyte HaCaT cells. Two out of four extracts showed a significantly selective effect towards the cancer cells and were found to contain high levels of phenolic and flavonoid compounds…

The principal compounds [in papaya leaf] identified were flavonoids or flavonoid glycosides, particularly compounds from the kaempferol and quercetin families, of which several have previously been reported to possess anticancer activities. These results confirm that papaya leaf is a potential source of anticancer compounds and warrant further scientific investigation to validate the traditional use of papaya leaf to treat cancer.”

Chemical Characterization and in Vitro Cytotoxicity on Squamous Cell Carcinoma Cells of Carica Papaya Leaf Extracts
Thao T. Nguyen 1, Marie-Odile Parat 1, Mark P. Hodson 1,2, Jenny Pan 1, Paul N. Shaw 1 and Amitha K. Hewavitharana 1,*
Received: 26 October 2015; Accepted: 18 December 2015; Published: 24 December 2015 Academic Editor: Carmela Fimognari

http://www.mdpi.com/2072-6651/8/1/7/pdf

International Journal of Herbal Medicine Documents Cancer Inhibition of Papaya Leaf

From Research Collected at the Bhupal’s Noble Institutes of Pharmaceutical Sciences in India’s largest state:

Carica papaya Linn: An Overview

Vijay Yogiraj, Pradeep Kumar Goyal, Chetan Singh Chauhan, Anju
Goyal, Bhupendra Vyas

February, 2015

” 5. Medicinal and Pharmacological properties of various parts of Carica papaya plant

5.1 Leaves
Papaya leaf has a numberless of benefits. In some parts of Asia, the young leaves of the papaya are steamed and eaten like spinach.
a) Dengue fever- Commencing on studies of Dr. Sanath Hettige, who conducted the research on 70 dengue fever patients, said papaya leaf juice helps increase white blood cells and platelets, normalizes clotting, and repairs the liver.
b) Cancer cell growth inhibition- Recent research on papaya leaf tea extract has demonstrated cancer cell growth inhibition. It appears to boost the production of key signaling molecules called Th1-type cytokines, which help regulate the immune system.
c) Antimalarial and antiplasmodial activity- Papaya leaves are made into tea as a treatment for malaria. Antimalarial and antiplasmodial activity has been noted in some preparations of the plant, but the mechanism is not
understood and not scientifically proven
d) Facilitate digestion- The leaves of the papaya plants
contain chemical compounds of carpain, Substance which kills microorganisms that often interfere with the digestive function.
Additional Benefits of Papaya Leaves: As an acne medicine, Increase appetite, Ease menstrual pain, Meat tenderizer, Relieve nausea.”

http://florajournal.com/vol2issue5/jan2015/2-4-12.1.pdf

Cancer Research Funds Papaya Leaf

IMG_1045.PNG

Three Australian Cancer Research Foundations funded this preliminary study on papaya leaf that was published this summer 2014.

Funded by
Ramaciotti Foundation. Grant Number: ES2012/0104
Cancer Australia and Cure Cancer Australia Foundation. Grant Number: 1033781
National Health and Medical Research Council Career Development Fellowship

The result of the study:
“Saponins and total phenolic compounds were assessed for their antioxidant, free radical scavenging, ion-reducing capacity, and antipancreatic cancer activity. Optimal aqueous extraction conditions were 85 °C, 25 min. and a water-to-leaf ratio of 20:1 mL g−1. Ethanol extracts demonstrated higher antioxidant, free radical scavenging and ion-reducing capacity, as well as antipancreatic cancer activity. This study revealed that the PL contains numerous bioactive compounds, with significant anticancer activity warranting further studies on the isolation and characterisation of individual bioactive compounds from the PL.”

Antioxidant and anticancer capacity of saponin-enriched Carica papaya leaf extracts

Vuong, Q. V., Hirun, S., Chuen, T. L.K., Goldsmith, C. D., Murchie, S., Bowyer, M. C., Phillips, P. A. and Scarlett, C. J. (2014), Antioxidant and anticancer capacity of saponin-enriched Carica papaya leaf extracts. International Journal of Food Science & Technology. doi: 10.1111/ijfs.12618

http://onlinelibrary.wiley.com/doi/10.1111/ijfs.12618/abstract

Papaya leaf tea has been an Aboriginal medicine for cancer made most famous by the personal experiences of Harold Tietze in 1978, Papaya the Medicine Tree

#alternativemedicine #cancer

What We Call PAPAYA Leaves For Cancer!

The Julia Ruffin Project grows, researches, and promotes papaya leaf tea.

This is what we call “Papaya” around the world:

ASSAMESE: Omita.
BENGALI: Pepe.
BURMESE: Thimbaw.
CZECH: Papaja.
ESTONIAN : Harilik papaia, Papaia.
FIJIAN: Oleti.
FRENCH: Papaye, Papayer.
GERMAN: Melonenbaum, Papayabaum.
GUJARATI: Papaiya, Papayi.
HAWAIIAN: He’i, Mikana, Milikana.
HINDI: Papeeta, Papiitaa.
ITALIAN: Papaia.
JAPANESE: Motukuwa, Papaia, Popoo.
KHMER: Ihong, Doeum lahong.
KOREAN: Pa pa ya.
LAOTIAN: Houng.
MALAY: Betek, Betik, Gedang, Kates, Ketalah. Papaya.
MALAYALAM: Karamooza, Omakai, Omakaya.
MARATHI: Papai, Papaya, Popai.
PALAUAN: Babai, Bobai.
POLISH: Melonowiec właściwy, Papaja.
PORTUGUESE: Ababaia, Mamao, Papaia, Fruto de Mamoeiro, Papaeira.
PUNJABI: Katcha pepita.
RUSSIAN: Papaia.
SAMOAN: Esi.
SPANISH: Fruta bomba, Lechosa, Melon de arbol, Melon zapote, Papayero, Papayo, Papaya.
SWAHILI: Papai.
THAI: Loko, Malako, Malakor, Ma kuai thet, Sa kui se.
TONGAN: Lesi, Lesi fefine
URDU: Papiitaa, Pappeeta.
VIETNAMESE: Du du.