Papaya Leaf Has The Caffeic Acid That Battles Prostate and Breast Cancer

Of the list of cancer-fighting phytochemicals found in papaya leaf, Caffeic Acid has been shown as the most abundant of any in the papaya leaf, and significantly more abundant in the leaf than in any other part of the papaya plant including the fruit.

-Proximate Analysis, Antioxidant and Anti Proliferative Activities of Different Parts of Carica papaya Maisarah AM1, Asmah R1 and Fauziah O2, 1Department of Nutrition and Dietetics, Universiti Putra Malaysia, Malaysia 2Department of Human Anatomy, Universiti Putra Malaysia, Malaysia

What is significant about this is that Caffeic acid has shown effect on fighting specifically Prostate and Breast cancer. Its use is also as a complement to standard drugs like Tamoxifen. See the selected studies below.

Prostate Cancer:

Breast Cancer:


56% of Breast Cancer Cells Inhibited by Papaya Leaf

Vietnamese researchers claim that 56% of breast cancer cells were inhibited by papaya leaf in the lab. The scientists also made note that the papaya leaf was harmless to the healthy cells. The control used was vitamin C, and papaya leaf showed a much higher antioxidant level with equal dosage.

Their research included tests on lung cancer (62% cells inhibited), and leukemia (60% cells inhibited).

-Research on Biological Activity of some Extracts from Vietnamese Carica papaya Leaves
Do Thi Hoa Vien, Phung Thi Thuy

ASEAN Journal of Chemical Engineering, vol. 12 no.2 (2012)

Pilot Study: White Cell Count Increases with Papaya Leaf Juice

This is not a new pilot study. But this is one that is worthy for promotion because cancer patients suffer from low white cell count. Papaya leaf is used as complementary treatment for cancers, and one reason is that it has shown to raise white cell count.

From, the following treatments may lower your white cell count:

“Breast cancer treatments that can lower your white blood cell count:

Abraxane (chemical name: albumin-bound or nab-paclitaxel)
Adriamycin (chemical name: doxorubicin)
carboplatin (brand name: Paraplatin)
Cytoxan (chemical name: cyclophosphamide)
Doxil (chemical name: doxorubicin)
Ellence (chemical name: epirubicin)
fluorouracil (also called 5-fluorouracil or 5-FU; brand name: Adrucil)
Gemzar (chemical name: gemcitabine)
Halaven (chemical name: eribulin)
Mitomycin (chemical name: mutamycin)
mitoxantrone (brand name: Novantrone)
Navelbine (chemical name: vinorelbine)
Taxol (chemical name: paclitaxel)
Taxotere (chemical name: docetaxel)
thiotepa (brand name: Thioplex)
radiation therapy
targeted therapy:
Avastin (chemical name: bevacizumab)
Herceptin (chemical name: trastuzumab)
Perjeta (chemical name: pertuzumab)
Tykerb (chemical name: lapatanib)”

Also the painful epidemic of chikungunya and Dengue Fever cause white cell count to be compromised.

The following pilot study shows that papaya leaf juice increased the white cell count of test subjects:

Salutary effects of carica papaya leaf extract in dengue fever patients – a pilot study
S Hettige1
Sri Lankan Family Physician, 2008, 29, 17-19

“From the [above] results it was evident that both the platelet counts and the total white cell counts had increased in all patients within 24 hours after administering papaya leaf juice. It is known that the platelet count drops in dengue patients after the first three days of fever and the gradually increases after the 7th day or drop further with derangement of other clotting factors to develop into dengue hemorrhagic state3. It was significant to observe that the platelet count increased in all 12 patients with two doses of papaya leaf juice and all patients recovered with no hospital admission….

This pilot study has shown the effects of papaya leaf juice in dengue patients of elevating the total white cell counts, platelet counts and recovery without hospital admission.
An adequate sample after obtaining ethical approval and advice from a statistician, doing clotting profiles before and after papaya intervention and using a control group would provide an answer to the question is papaya leaf extract effective in elevating the platelet count and clotting factors which are compromised in dengue fever.”


Dr S. Hettige

Egypt and South Africa: Papaya “aerial parts” Show Effect Against Breast Cancer in Lab

We are publishing lab studies done around the world that show the effect of papaya leaf on cancer to encourage cancer research organizations to direct resources toward clinical trials. Papaya leaf tea (cut papaya leaf herb) is inexpensive and available to market as a natural product.

South African and Egyptian scientists worked together at the end of 2013 to show effect of papaya plant “aerial parts” on breast cancer. The Julia Ruffin Project wants to acknowledge their work and success in proving effect in the lab. See the study details below.

Greener Journal of Pharmacy and Pharmacology Vol. 1 (1), pp. 001-005, October 2013
Research Article
Anticancer Activity of Carica papaya Extracts in vito and Phytochemical Analysis
Khaled N. Rashed1*, Gerda Fouche2
1National Research Centre, Pharmacognosy Department, Dokki, Giza, Egypt.
2Natural Product Chemistry Group, Council for Scientific and Industrial Research, PO Box 395, Pretoria 0001, South Africa.

The reported results show that petroleum extract of C. papaya aerial parts has significant anticancer effect on MCF7 (breast) cancer cells. Thus, C. papaya aerial parts could be helpful in cancer prevention and treatment. C. papaya could be a natural source of anticancer compounds with anti proliferative and/or apoptotic properties and as well, due to its anticancer pharmacological effect,
clinical trials are recommended to evaluate the beneficial effects of this plant in human models.”


The Julia Ruffin Project promotes, researches, and test-farms papaya leaf tea

Older posts related to breast cancer and papaya leaf:


Papain in Papaya Leaf has Potential for Tumors; Breast Cancer


The Scottish Doctor John Beard discovered that by injecting the proteases taken from a young calf into a cancerous human tumor his patients could be cured.

Research in Brazil on the protease papain (can be taken from the raw papaya fruit or the leaves of the papaya tree) shows a potential contemporary use of papain on implant surgery to prevent painful fibrous buildup.

This is similar action to Dr Beard’s thinking centuries ago to inject a cancerous, fibrous tumor with a protein dissolving enzyme. It seems this action may also have systemic effect via the bloodstream, as Dr Nam Dang proved similar effect on tumors as well from the action of papaya leaf tea.

See the Brazilian study from 2008:


“The capsular contracture is the most common adverse effect after breast implant [1]. Fibrotic tissue promotes compression around the implant which distorts and deforms the mass which then compromises the aesthetic result and is associated with painful symptoms [2]-[4]. The development of a fibrotic capsule around foreign material is a physiologic reaction of the organism to protect itself from material it does not recognize [5]. The severity of capsule contracture is directly related to the degree of the local inflammatory reaction [6] and does not depend on the implant surface employed [7]. Although it is not clear the pathogenesis of capsular contracture, this phenomenon seems to be multifactorial [8].
Currently, there is no effective preventive measure for capsule contracture [8]. The conventional treatment may be surgical, by capsulectomy (or capsulotomy) or implant replacement and pharmacological using steroids, anti- leukotrienes, anti-TGF-β, antibiotics or antiinflamatories [2], [3].
Up to now there has been no accurate and reproducible pathologic model for examining capsular contracture [9]. This study assumes that eventual interference by papain (PA) on normal healing could be useful in further studies of a more complex model with induced capsule contracture [9].
Some authors have speculated on the possible modulator action of certain proteolytic enzymes present around the implants in the early stages of healing [10], [11].
Papain is a thiol endopeptidase plant whose activity is similar to the lysosomal cathepsin B enzyme with fibrinolytic and proteolytic action on the normal healing mechanism [12].
It has been suggested that the papain could be helpful when used locally around the implant at the surgical procedure, promoting tissue repair with less fibrotic tissue, thus avoiding the capsule contracture.
The aim of this study was to investigate the papain effects on the fibrous capsule thickness, collagen fibers density and myofibroblasts around textured implants in rats.
Abstract— Objective: To study the tissue repair around the textured mammary implants under the action of papain (PA). Conclusion: The papain drug decreased the fibrous capsule formation around the textured silicon implants in rats.”

The papain local depot impairs the capsule fibrous healing around textured silicone implants in rats.
Marcio Moreira, Djalma José Fagundes, Sanderland José Tavares Gurgel

Mexican Scientists Show Papaya Plant effects Breast Cancer Cell Line MCF-7

International Journal of Food Science Nutrition 2009

Screening of antiproliferative effect of aqueous extracts of plant foods consumed in Mexico on the breast cancer cell line MCF-7.
Garcia-Solis P., Yahia E.M., Morales-Tlalpan V., Diaz-Munoz M.,Facultad de Ciencias Naturales, Universidad Autonoma de Queretaro, Campus UAQ-UNAM Juriquilla, Queretaro, Mexico.

We evaluated the antiproliferative effect of aqueous extracts of 14 plant foods consumed in Mexico on the breast cancer cell line MCF-7. The plant foods used were avocado, black sapote, guava, mango, prickly pear cactus stems (called nopal in Mexico, cooked and raw), papaya, pineapple, four different cultivars of prickly pear fruit, grapes and tomato. beta-Carotene, total phenolics and gallic acid contents and the antioxidant capacity, measured by the ferric reducing/antioxidant power and the 2,2-diphenyl-1,1-picrylhydrazyl radical scavenging assays, were analyzed in each aqueous extract. Only the papaya extract had a significant antiproliferative effect measured with the methylthiazolydiphenyl-tetrazolium bromide assay. We did not notice a relationship between the total phenolic content and the antioxidant capacity with antiproliferative effect. It is suggested that each extract of plant food has a unique combination of the quantity and quality of phytochemicals that could determine its biological activity. Besides, papaya represents a very interesting fruit to explore its antineoplastic activities.

Universidad Autonoma de Queretaro

The Julia Ruffin Project promotes, researches, and grows papaya leaf tea.