Papaya Leaf Shows Activity Against E-Coli: Research Published by International Journal

“The leaves of Carica papaya are used in herbal medical practices in South East Nigeria to treat malaria and typhoid fever which engendered a probe of its chemical constituents…
The extract showed potent antimicrobial activity against Staphylococcus aureus,streptococcus faecalis, Escherichia coli and Proteus mirabilis… This research lends credence to the use of C. papaya in herbal medicine in Nigeria.”

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CHEMICAL CONSTITUENTS OF THE LEAF ESSENTIAL OIL OF CARICA PAPAYA FROM SOUTH EAST NIGERIA
AND ITS ANTIMICROBIAL ACTIVITY

OU. Igwe
Department of Chemistry, Michael Okpara University of Agriculture, Umudike, P.M.B. 7267 Umuahia, Abia State, Nigeria.
IJRPC 2015, 5(1), 77-83 Igwe ISSN: 22312781 INTERNATIONAL JOURNAL OF RESEARCH IN PHARMACY AND CHEMISTRY

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Papaya Leaf Tea as Antibiotic

“The activity of the extracts was comparable to those of antibiotics.”

Antimicrobial Activity of Carica Papaya (Pawpaw Leaf) on Some Pathogenic Organisms of Clinical Origin from South-Western Nigeria

*I.I. Anibijuwon and A.O. Udeze

Department of Microbiology, University of Ilorin, P.M.B. 1515, Ilorin, Nigeria

http://www.ethnoleaflets.com/leaflets/anibiude.htm

MAHMUDA BEGUM Shows Antibacterial Effect of Papaya Leaf

Pharmocological investigator shows the antibacterial effect of papaya leaf against the major infectious bacteria to humans. See the results of his study below:

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Begum Comments…
“The results of antibacterial sensitivity of methanolic extract of Carica papaya leaf by disc diffusion method are in depicted below graph and table. The results reveal that the extract has Antimicrobial activity against all the pathogenic organisms studied. The antibacterial activity was screened from the zone of inhibition….”

http://dspace.ewubd.edu/bitstream/handle/123456789/685/Mahmauda_Begum.pdf?sequence=1

PHYTOCHEMICAL AND PHARMACOLOGICAL INVESTIGATION OF CARICA PAPAYA LEAF
DEPARTMENT OF PHARMACY EASTWEST UNIVERSITY
AFTABNAGAR, DHAKA
A DISSERTATION SUBMITTED TO THE DEPARTMENT OF PHARMACY, EASTWEST UNIVERSITY IN THE PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE DEGREE OF BACHELOR OF PHARMACY.
SUBMITTED BY MAHMUDA BEGUM
ID NO: 2009-3-70-017
January, 2014

The Julia Ruffin Project promotes, researches, and test-farms papaya leaf tea.

Papaya Leaf May Make The New Antibiotic

The following study looks at the extract of papaya leaf and its antibacterial effect in the lab on gram-negative and gram-positive bacteria:

1.B.Subtilitis
2.B.megaterium
3.B.cerus
4.B.haemolytic streptococcus
5.Candida albicans

The extract is found to have broad-spectrum antibacterial activity and also used as analgesics and narcotics for pain relief. A report indicate that plant extracts are more active against Gram-positive bacteria than Gram-negative bacteria while that of the leaf extract of C. papaya was next to the most sensitivity with the Gram-negative bacteria especially Proteus mirabilis (Jigna and Sumitra, 2006). The activity of the extract is comparable to those of antibiotics. The demonstration of activity against the test bacteria provides scientific bases for the local usage of the plant in the treatment of various ailments. The fact that the extract is active against Gram-positive bacteria and Fungi tested may indicate a broad spectrum of activity. This observation is very significant because of the possibility of developing therapeutic substances that will be active against multidrug-resistant organisms.”

PHYTOCHEMICAL AND PHARMACOLOGICAL INVESTIGATION OF CARICA PAPAYA LEAF
By MAHMUDA BEGUM

DEPARTMENT OF PHARMACY EASTWEST UNIVERSITY AFTABNAGAR, DHAKA

http://dspace.ewubd.edu/bitstream/handle/123456789/685/Mahmauda_Begum.pdf?sequence=1

Current Research Shows Papaya Leaf Tea is Active Against Human Pathogens

Researchers just this year have published on the effect of papaya leaf tea (aqueous extract of papaya leaf) on human pathogens. Pakistani researcher Sherwani points out that we need to find a new bio active compound to combat infectious disease. In the study below his team showed effect of papaya leaf tea on seventeen human and plant pathogenic fungi. The study was published in the International Research Journal of Pharmacy 9/6/13.

http://www.irjponline.com/admin/php/uploads/1897_pdf.pdf

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Antibody Structure of the Enzyme in Papaya Leaf

Diagram from Life Technologies Site:
http://www.lifetechnologies.com/us/en/home/references/molecular-probes-the-handbook/technical-notes-and-product-highlights/antibody-structure-and-classification.html

The Life Technologies diagram is referring to the antibody structure of papain. Papain is one of two unique primary enzymes found in the papaya leaf. Notice the binding to macrophages… These can be thought of as the "trash collection" at the cellular level.

This company is a major player in the Pharma industry and takes room to make note of the special antibody binding of papain.

In an earlier blog on this site a study is reviewed that tested papaya leaf and its potential as an antibiotic for six potent human diseases.

The Julia Ruffin Project researches, grows and promotes papaya leaf tea.

See http://www.papayaleavesforcancer.com

Pakistan Scientists Show Papaya Leaf Potential for Infectious Disease Breakthrough

A new 2013 publication in the International Research Journal of Pharmacy tested papaya leaf “tea” and papaya leaf extract on various pathogenic fungi (fungi that cause disease in humans) to show its potential to counter infectious diseases especially against drug resistant microbes. Both the tea and the extract showed effect against six saprophytic (parasites on the fungus on dead matter-not directly on dead matter) fungi. We thank the researchers below:

Sikandar Khan Sherwani, Tasveer Zahra Bokhari, Kanwal Nazim, Syed Aneel Gilani, Shahana Urooj Kazmi. Qualitative Phytochemical Screening and Antifungal Activity of Carica Papaya Leaf Extract Against Human and Plant Pathogenic Fungi

http://www.irjponline.com/admin/php/uploads/1897_pdf.pdf