Papaya Leaf Slows Free Radical Destruction that Causes Aging and Cancer

We have published research articles that show the healing effect of papaya leaf on the liver. But this study explains how this action also has anti-aging and anti-cancer effects:

From the International Journal of Pharmacy

“…In general up on entry of any foreign particle enters in to our body. Free radicals can be generated, which is based on the size of the foreign particle or physico chemical characteristics of that foreign particle (1). The free radicals are not inactivated; their chemical reactivity can damage all cellular macromolecules including proteins, carbohydrates, lipids and nucleic acids. Their destructive effect on protein may play a role in the causation of diseases, like cataracts. Free radical damage to DNA is also implicated in the causation of cancer and its effect on LDL cholesterol is very likely responsible for heart disease. Free radicals are also responsible for ageing (2).
Iron over load causes liver toxicity by producing hydroxyl radicals by promoting Fenton reaction(3). Free radicals also can be able to cause various
diseases like neurodegenerative diseases (4), cardio vascular diseases (5), cancer etc. So the work started because of these serious effects up on the free radical generation, expecting that Herbal medicines have been used able to generate antioxidants, which can be provide balance between free radical generation and anti-oxidant levels or those anti-oxidants prevents the liver damage and gastric ulceration caused by free radicals….
In present study the antioxidant activity of aqueous extract of leaf of Carica papaya was found. From the study it was also found to decrease lipid peroxidation and significant increase in catalase, glutathione and protein with the aqueous extract of leaf of Carica papaya in dose dependant manner. Literature regarding phytoconstituents shows that aqueous extract of leaf of Carica papaya contains Alkaloids Carpain, Pseudo carpain, and dehydro carpaine I & II, Choline, Caproside, Vitamin C & E. Since all these constituents are found in the leaf of this plant it is possible that these constituents may be implicated in antioxidant activity of the species. Therefore, it was concluded that the aqueous extract of the leaf of Carica papaya possess antioxidant principles and has free radical scavenging activity.
CONCLUSION
The result have shown that the aqueous extract of the leaf of Carica papaya possesses antioxidant properties, supported by the decrease in lipid peroxidation and increase in the reduced glutathione and catalase activity in in vivo method. The in vivo antioxidant activities have been supported by its free radical scavenging activities in in-vitro method. Such antioxidant activity of Carica papaya might be responsible for its importance in traditional medicine for the treatment of various disorders. The present study opens many new areas of research work. This work can be continued in the future to study and confirm liver protective activity in different experimental models and also to isolate, identify, characterize and standardize the active principle(s) that are responsible for this activity.”

-IRON OVER LOAD INDUCED LIVER TOXICITY OF AQUEOUS LEAF EXTRACT
OF CARICA PAPAYA IN RATS
Balakrishna V*, Srikanth G, Ajay kumar Sarabu, Thippani Maneshwar
Department of Pharmacology, Vaageswari College of Pharamacy, Karimnagar, Andhra Pradesh, India
International Journal of Pharmacy
Journal Homepage: http://www.pharmascholars.com

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