“PAPAYA (CARICA PAPAYA): SOURCE MATERIAL FOR ANTICANCER”

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Figure is [enzyme] Papain Structure (Huet J et al., 2006)

“…Phytochemicals in c. Papaya with Reported Anticancer Activities
Carica papaya contains a broad spectrum of Phytochemicals including enzymes (in the latex), Carotenoids (in fruits and seeds), alkaloids (in leaves), phenolics (in fruits, leaves, and shoots), glucosinolate (in seeds and fruits) (Krishna et al., 2008; Parle et al., 2011). Some important Phytochemicals found in C. papaya are Lycopene, Betacarotinoid, Benzylisothyocynate, Betacryptoxanthin, Benzylglucosinolate, chlorogenic acid, caffeic acid, protocatachuic acid, Quercetin, Among more than 5000 compounds from plants that have been identified to be associated with anticancer properties (Huang et al., 2009), three groups of bioactive compounds-phenolics, Carotenoids, and glucosinolate-have attracted considerable interest in anticancer studies. Pure compounds of these three groups have been extensively researched in vivo and in vitro studies on many types of cell lines for their potential effects in cancer treatment and prevention. These bio actives act via multiple mechanisms such as cancer cell signalling, proliferation, apoptosis, migration, invasion, as well as angiogenesis and carcinogen elimination (Huang et al., 2009; Zhang et al.., 2004; Thornalley et al., 2002; Nakamura et al., 2006; Wu et al., 2009; Navarro et al., 2011; Wahle et al., 2011; Soobrattee et al.., 2006; Tanaka et al., 2012; Breemen et al., 2008) to exhibit in vitro and in vivo anticancer activities.”

http://www.cibtech.org/J-Pharmaceutical-Sciences/PUBLICATIONS/2013/Vol-2-No-1/05-008…Krishnamurthy…Papaya…Anticancer…25-33.pdf

CIBTech Journal of Pharmaceutical Sciences ISSN: 2319–3891 (Online)
An Online International Journal Available at http://www.cibtech.org/cjps.htm 2013 Vol.2 (1) January-March, pp.25-34/Sheikh and Krishnamurthy
Review Article
PAPAYA (CARICA PAPAYA): SOURCE MATERIAL FOR ANTICANCER
*Sheikh Fauziya and R Krishnamurthy
CG Bhakta Institute of Biotechnology, Uka Tarsadia University, Maliba Campus Bardoli, Dist. Surat, Gujarat, India-394350
*Author for Correspondence

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