Papaya Leaf Shows Activity Against E-Coli: Research Published by International Journal

“The leaves of Carica papaya are used in herbal medical practices in South East Nigeria to treat malaria and typhoid fever which engendered a probe of its chemical constituents…
The extract showed potent antimicrobial activity against Staphylococcus aureus,streptococcus faecalis, Escherichia coli and Proteus mirabilis… This research lends credence to the use of C. papaya in herbal medicine in Nigeria.”

2015/09/img_1552.png

CHEMICAL CONSTITUENTS OF THE LEAF ESSENTIAL OIL OF CARICA PAPAYA FROM SOUTH EAST NIGERIA
AND ITS ANTIMICROBIAL ACTIVITY

OU. Igwe
Department of Chemistry, Michael Okpara University of Agriculture, Umudike, P.M.B. 7267 Umuahia, Abia State, Nigeria.
IJRPC 2015, 5(1), 77-83 Igwe ISSN: 22312781 INTERNATIONAL JOURNAL OF RESEARCH IN PHARMACY AND CHEMISTRY

Papaya Leaf for Dengue in Delhi

“Delhi government struggles with dengue outbreak
Extra hospital beds ordered and medical-staff leave cancelled amid warning situation in Indian capital could worsen.”
Showkat Shafi | 19 Sep 2015 10:30 GMT | Health, Dengue, India, Asia
http://www.aljazeera.com/news/2015/09/delhi-government-struggles-dengue-outbreak-150919053907482.html

A respected European Journal notes the Aryvetic approach to managing dengue fever.

Given the recommendation to treat with papaya leaf, and the abundance of this herb in India, it may be profitable to society for papaya plantations to supply hospitals in Delhi with leaves (given the reported nature of the current health crisis.)

“The juice of papaya leaf has been found to be useful in the treatment of dengue fever. A number of scientific papers have proved that papaya leaf juice is actually beneficial for the body. Few recent studies have shown the effect of papaya leaf juice in curing the dengue fever. A recent one, done on five dengue patients by Indian Institute of Forest Management in 2012, found interesting observations. Among the five patients, papaya leaf juice was found to be effective in curing dengue. The platelet count increased in all five patients within 24 hours of drinking the papaya leaf juice. All of them reported significant improvement in health.[10]
A 2009 study, done on mice in Malaysia, reported significant improvement in thrombolytic count in the group which received papaya leaf formulations compared to the control group. It seems that this bitter green juice is promising without posing any serious ill-effects.”

ejpmr, 2015,2(4), 693
EUROPEAN JOURNAL OF PHARMACEUTICAL AND MEDICAL RESEARCH
http://www.ejpmr.com
Research Article search
ISSN 3294-3211
EJPMR
“AN AYURVEDIC INSIGHT TOWARDS DENGUE FEVER”
Dr. Sumit Srivastava*
Associate Professor, Dept. of Rog-nidan, Shri Dhanwantry Ayurvedic College, Chandigarh.
Article Received on 18/05/2015 Article Revised on 12/06/2015 Article Accepted on 04/07/2015

http://archive.indianexpress.com/news/bitter-treatment-papaya-leaves-can-fight-dengue- cancer/1178680/.

The Julia Ruffin Project promotes and researches papaya leaf for its effect on cancer and disease.

Papaya Leaf Slows Free Radical Destruction that Causes Aging and Cancer

We have published research articles that show the healing effect of papaya leaf on the liver. But this study explains how this action also has anti-aging and anti-cancer effects:

From the International Journal of Pharmacy

“…In general up on entry of any foreign particle enters in to our body. Free radicals can be generated, which is based on the size of the foreign particle or physico chemical characteristics of that foreign particle (1). The free radicals are not inactivated; their chemical reactivity can damage all cellular macromolecules including proteins, carbohydrates, lipids and nucleic acids. Their destructive effect on protein may play a role in the causation of diseases, like cataracts. Free radical damage to DNA is also implicated in the causation of cancer and its effect on LDL cholesterol is very likely responsible for heart disease. Free radicals are also responsible for ageing (2).
Iron over load causes liver toxicity by producing hydroxyl radicals by promoting Fenton reaction(3). Free radicals also can be able to cause various
diseases like neurodegenerative diseases (4), cardio vascular diseases (5), cancer etc. So the work started because of these serious effects up on the free radical generation, expecting that Herbal medicines have been used able to generate antioxidants, which can be provide balance between free radical generation and anti-oxidant levels or those anti-oxidants prevents the liver damage and gastric ulceration caused by free radicals….
In present study the antioxidant activity of aqueous extract of leaf of Carica papaya was found. From the study it was also found to decrease lipid peroxidation and significant increase in catalase, glutathione and protein with the aqueous extract of leaf of Carica papaya in dose dependant manner. Literature regarding phytoconstituents shows that aqueous extract of leaf of Carica papaya contains Alkaloids Carpain, Pseudo carpain, and dehydro carpaine I & II, Choline, Caproside, Vitamin C & E. Since all these constituents are found in the leaf of this plant it is possible that these constituents may be implicated in antioxidant activity of the species. Therefore, it was concluded that the aqueous extract of the leaf of Carica papaya possess antioxidant principles and has free radical scavenging activity.
CONCLUSION
The result have shown that the aqueous extract of the leaf of Carica papaya possesses antioxidant properties, supported by the decrease in lipid peroxidation and increase in the reduced glutathione and catalase activity in in vivo method. The in vivo antioxidant activities have been supported by its free radical scavenging activities in in-vitro method. Such antioxidant activity of Carica papaya might be responsible for its importance in traditional medicine for the treatment of various disorders. The present study opens many new areas of research work. This work can be continued in the future to study and confirm liver protective activity in different experimental models and also to isolate, identify, characterize and standardize the active principle(s) that are responsible for this activity.”

-IRON OVER LOAD INDUCED LIVER TOXICITY OF AQUEOUS LEAF EXTRACT
OF CARICA PAPAYA IN RATS
Balakrishna V*, Srikanth G, Ajay kumar Sarabu, Thippani Maneshwar
Department of Pharmacology, Vaageswari College of Pharamacy, Karimnagar, Andhra Pradesh, India
International Journal of Pharmacy
Journal Homepage: http://www.pharmascholars.com

“PAPAYA (CARICA PAPAYA): SOURCE MATERIAL FOR ANTICANCER”

2015/09/img_1433.png
Figure is [enzyme] Papain Structure (Huet J et al., 2006)

“…Phytochemicals in c. Papaya with Reported Anticancer Activities
Carica papaya contains a broad spectrum of Phytochemicals including enzymes (in the latex), Carotenoids (in fruits and seeds), alkaloids (in leaves), phenolics (in fruits, leaves, and shoots), glucosinolate (in seeds and fruits) (Krishna et al., 2008; Parle et al., 2011). Some important Phytochemicals found in C. papaya are Lycopene, Betacarotinoid, Benzylisothyocynate, Betacryptoxanthin, Benzylglucosinolate, chlorogenic acid, caffeic acid, protocatachuic acid, Quercetin, Among more than 5000 compounds from plants that have been identified to be associated with anticancer properties (Huang et al., 2009), three groups of bioactive compounds-phenolics, Carotenoids, and glucosinolate-have attracted considerable interest in anticancer studies. Pure compounds of these three groups have been extensively researched in vivo and in vitro studies on many types of cell lines for their potential effects in cancer treatment and prevention. These bio actives act via multiple mechanisms such as cancer cell signalling, proliferation, apoptosis, migration, invasion, as well as angiogenesis and carcinogen elimination (Huang et al., 2009; Zhang et al.., 2004; Thornalley et al., 2002; Nakamura et al., 2006; Wu et al., 2009; Navarro et al., 2011; Wahle et al., 2011; Soobrattee et al.., 2006; Tanaka et al., 2012; Breemen et al., 2008) to exhibit in vitro and in vivo anticancer activities.”

http://www.cibtech.org/J-Pharmaceutical-Sciences/PUBLICATIONS/2013/Vol-2-No-1/05-008…Krishnamurthy…Papaya…Anticancer…25-33.pdf

CIBTech Journal of Pharmaceutical Sciences ISSN: 2319–3891 (Online)
An Online International Journal Available at http://www.cibtech.org/cjps.htm 2013 Vol.2 (1) January-March, pp.25-34/Sheikh and Krishnamurthy
Review Article
PAPAYA (CARICA PAPAYA): SOURCE MATERIAL FOR ANTICANCER
*Sheikh Fauziya and R Krishnamurthy
CG Bhakta Institute of Biotechnology, Uka Tarsadia University, Maliba Campus Bardoli, Dist. Surat, Gujarat, India-394350
*Author for Correspondence