“Papaya leaves exhibit anti-tumor, immunomodulatory (1), and antioxidant(9) effects in vitro….
Mechanism of Action
Papaya leaf extract modulates the immune system by enhancing the production of Th1 type cytokines, such as interleukin (IL-12), interferon (IFN-gamma) and tumor necrosis factor (TNF-alpha). Fractions with molecular weight less of than 1000 are most active in inhibiting tumor cell growth.”
The record on the website cites the references below:
1. Otsuki N, Dang NH, Kumagai E, et al. Aqueous extract of Carica papaya leaves exhibits anti-tumor activity and immunomodulatory effects. J Ethnopharmacol. Feb 17 2010;127(3):760-767.
9. Okoko T, Ere D. Reduction of hydrogen peroxide-induced erythrocyte damage by Carica papaya leaf extract.Asian Pac J Trop Biomed.2012 Jun;2(6):449-53.”
Constituents Recorded in the papaya leaf:
Carpaine, malic acid, quinic acid, manghaslin and clitorin, minor quantities of various malic acid derivatives, nicotiflorin, and rutin.(6)
Phenolic compounds: Dimethoxycoumarin, protocatechuic acid, p-coumaric acid, caffeic acid, chlorogenic acid, kaempferol and quercetin. (8)”