Papain is an active enzyme found in the natural papaya leaf. Papain is typically combined with two other proteases in oral enzyme therapy. The clinical study referenced below shows a significant positive difference in the survival rate for patients taking papain.
Systemic Enzyme Therapy in Oncology Effect and Mode of Action
Jörg Leipner and Reinhard Saller
Drugs 2000 Apr; 59 (4): 769-780
“…In this retrospective parallel-group cohort analysis, 166 patients who had received papain/trypsin/chymotrypsin (2 tablets 3 times daily) for at least 6 months were assigned to the active treatment group. The aim of the study was to investigate any effect of enzyme therapy on survival. A statistically significant mean prolongation of survival of 36 months was seen in patients with Stage III multiple myeloma (n = 54) in the enzyme group compared with the control group (n = 36) [83 months versus 47 months].”
Additional cases were reviewed naming less suffering and more survival when oral enzyme therapy that included papain was used as a complement to chemotherapy and radiation.
The mechanism of action was concluded to be:
“…This may constitute one of the mechanisms of action of enzyme therapy: orally administered enzymes seem to induce the synthesis of antiproteinases which in turn inactivate proteinases such as cathepsines”