Colon Cancer Interrupted by Saponins in Papaya Leaf

“The papaya (Carica papaya) leaf (PL) contains high levels of saponins and polyphenolic compounds, and historically, it has been used as a folk medicine for numerous ailments, including cancer…”

Original Article
Antioxidant and anticancer capacity of saponin-enriched Carica papaya leaf extracts

Quan V. Vuong1,2, Sathira Hirun1,2, Tiffany L.K. Chuen1,2, Chloe D. Goldsmith1,2, Shane Murchie2, Michael C. Bowyer1,2, Phoebe A. Phillips3 andChristopher J. Scarlett1,2,4,*
Article first published online: 15 JUL

DOI: 10.1111/ijfs.12618

© 2014 Institute of Food Science and Technology
International Journal of Food Science & Technology
Volume 50, Issue 1, pages 169–177, January 2015

“Saponins Fight Cancer in Three Distinct Ways:

1. Cancer cells have a different membrane structure, with a more cholesterol-like compounds. As saponins bind cholesterol, they likewise have a natural affinity to bind cancer cell membranes preventing them from entering the body through the intestinal tract where they have the ability to attach themselves to vital organs and grow.

2. Saponins bind bile acids. Some bacteria in the large intestine turn primary bile into a substance that is highly carcinogenic (that is why a high fat diet increases the risk of colon cancer). By binding these primary bile acids, saponins stop this toxic material from forming in the body.

3. Saponins flush pathogens through the digestive system without allowing them to be absorbed into the body (see Strengthening The Immune System). This process relieves a tremendous amount of work off the immune system. With less stress, your body can more effectively identify and destroy cancer cells.”

Papaya Leaf Tea Changed His PSA, Says California Man

Letter to the Blogger:

In 2002 I was diagnosed with prostate cancer. I chose to treat my cancer with proton radiation.
In the fall of 2009 my PSA went up and the prostate biopsy again came up positive.
In January I had cryoablation treatment of the prostate and within weeks my PSA went even higher.
At that point tests were performed that showed the cancer had spread to the lymph nodes. At the recommendtion of the urologist I went on hormone therapy (Lupron). The side effects from the hormone treatment were not pleasant.
In August of 2013 friends told me about papaya leaf tea for cancer and I started drinking the tea that month. My last hormone treatment was April 2014. My PSA test in December 2014 was 0.633.
My urologist could not believe the test as the last time I went 8 months without the hormones my PSA went to 66.
The only explanation for this amazing result is Papaya Leaf Tea.
Thank you Virginia for the input and encouragement that you have given me for drinking the tea.”

We have not published the name of this man but will release his name for specific requests with his permission after a review of the reason for the request. Send in a request and reason to

The Julia Ruffin Project promotes, researches, and test-farms papaya leaf tea.

Memorial Sloan Cancer Center Records that Papaya Leaf Has Anti- Tumor Effect

“Papaya leaves exhibit anti-tumor, immunomodulatory (1), and antioxidant(9) effects in vitro….

Mechanism of Action
Papaya leaf extract modulates the immune system by enhancing the production of Th1 type cytokines, such as interleukin (IL-12), interferon (IFN-gamma) and tumor necrosis factor (TNF-alpha). Fractions with molecular weight less of than 1000 are most active in inhibiting tumor cell growth.”

The record on the website cites the references below:
1. Otsuki N, Dang NH, Kumagai E, et al. Aqueous extract of Carica papaya leaves exhibits anti-tumor activity and immunomodulatory effects. J Ethnopharmacol. Feb 17 2010;127(3):760-767.
9. Okoko T, Ere D. Reduction of hydrogen peroxide-induced erythrocyte damage by Carica papaya leaf extract.Asian Pac J Trop Biomed.2012 Jun;2(6):449-53.”

Constituents Recorded in the papaya leaf:
Carpaine, malic acid, quinic acid, manghaslin and clitorin, minor quantities of various malic acid derivatives, nicotiflorin, and rutin.(6)
Phenolic compounds: Dimethoxycoumarin, protocatechuic acid, p-coumaric acid, caffeic acid, chlorogenic acid, kaempferol and quercetin. (8)”

MAHMUDA BEGUM Shows Antibacterial Effect of Papaya Leaf

Pharmocological investigator shows the antibacterial effect of papaya leaf against the major infectious bacteria to humans. See the results of his study below:


Begum Comments…
“The results of antibacterial sensitivity of methanolic extract of Carica papaya leaf by disc diffusion method are in depicted below graph and table. The results reveal that the extract has Antimicrobial activity against all the pathogenic organisms studied. The antibacterial activity was screened from the zone of inhibition….”

ID NO: 2009-3-70-017
January, 2014

The Julia Ruffin Project promotes, researches, and test-farms papaya leaf tea.

Drugs Containing Papaya Leaf Enzyme Used As Complementary Medicine for Chemotherapy and Radiation

Papaya Leaf Tea contains the active enzymes papain and chymopapain used in these prescription drugs as below:


Find interchangeable branded or generic drugs, if you could not find the prescribed medicine. This site does not supply any medicines. It contains prices for information purposes only.
You should consult a doctor about the dosage before using this medicine!

Uses and prices Sort by popularity
Truzyme – Indications: Pellagra.
Hartnups disease.

Peripheral vascular disease.


Active ingredients: Papain
Unit description, dosage Price, USD
Truzyme 200 ml MDC Syrup $ 0.02
Truzyme 30 ml Drop $ 0.07
Truzyme 15 ml Drop $ 0.60
Truzyme 200 ml Syrup $ 0.07
List of truzyme brand name and generic drugs
Inzyme – Indications: oedema, inflammation
Inzyme consists chiefly of a mixture of Inzyme and chymopapain, proteolytic enzymes that hydrolyse polypeptides, amides, and esters, especially at bonds involving basic amino acids, or leucine or glycine, yielding peptides of lower molecular weight. It is used for the inflamation of soft tissue. Preparations of papain, alone or combined with antibacterial agents and/or other substances, have been taken by mouth for their supposed anti-inflammatory properties, and it has also been used as an ingredient of various mixtures claimed to aid digestion. Inzyme is widely used as a meat tenderiser and in the clarification of beverages. Malignant neoplasms. Papain has been included in proteolytic enzyme preparations used in oncology to reduce the adverse effects of chemotherapy and radiotherapy. Although the number of clinical studies on which to judge efficacy is limited, a review1 of such studies suggested that systemic enzyme therapy might be beneficial. Clinical studies have used a preparation containing papain, trypsin, and chymotrypsin in a weight ratio of 5:2:2, and the beneficial effect seems to be based on its anti-inflammatory potential.

Inzyme 200 ml Syrup $ 0.03
Neopeptine Dps
Neopeptine Dps 15 ml Drop $ 0.05
Nitizyme 100 ml Syrup $ 0.02
Nuzyme 15 ml Drop $ 0.04
Nuzyme 100 ml Syrup $ 0.03
Nuzyme 200 ml Syrup $ 0.02
Onzyme 50+10 Capsule $ 0.05
Onzyme Papain 60 mg, lysinehydrochloride 15 mg,niacinamide 2.25 mg, thiaminemononitrate 2.25 mg,pyridoxine hydrochloride 0.75mg. SYR / 200ml $ 1.19
Orizyme 100 ml Syrup $ 0.02
Panafil (United States)
Papain (Poland)
Papain Biopharmi (Georgia)
Papain Marching (Hong Kong)
Papaya Enzyme
Tablet; Oral; Papain 29.5 mg
Tablet; Oral; Papain 30 mg
Tablet; Oral; Papain 200 mg
Papenzima (Chile)
Tablet; Oral; Papain 5 mg
Quest Enzyme Digest (Malaysia)
Quest Enzyme Digest 90’s
Solarcaine Stop Itch
Solarcaine Stop Itch First Aid Lotion
Lotion; Topical; Papain 3.55%
Stop Itch
Super Papaya Enzyme
Tablet; Oral; Papain 90 mg
Syszyme 100+60 Capsule $ 0.03
Tromasin SA
Uzyme 200 ml Syrup $ 0.02
V Zyme
V Zyme 200 ml Syrup $ 0.02
Xymex 40+30 Tablet $ 0.02
Xymex 15 ml Drop $ 0.03
Xymex 200 ml Syrup $ 0.02
Xymex Pepsin 10 mg, papain 6 mg,sodium citrate 40 mg/5 mL,citric acid 8 mg, ginger oil0.001 mL, cinnamon oil 0.001mL/1 mL. O-DPS / 15ml $ 0.46
Zymax C
Zymax C 30 ml Drop $ 0.02
Zymax C 15 ml Drop $ 0.03
Zymin 15 ml Drop ”

Read more:

Prostatisis Inflammation targeted with Papaya Leaf Tea

A well known clinical study in 1999 successfully showed that papain (the active enzyme in the papaya leaf) combined with bromelain (also a protease enzyme but from the core of the pineapple) combined with a bioflavonoid caused 82% of men studied to have a 25% improvement in symptoms.

Quercetin in men with category III chronic prostatitis: a preliminary prospective, double-blind, placebo-controlled trial.

Shoskes DA1, Zeitlin SI, Shahed A, Rajfer J.

Wikipedia defines bioflavonoids as “flavonoids”.
“….The terms flavonoid and bioflavonoid have also been more loosely used to describe non-ketone polyhydroxy polyphenol compounds which are more specifically termed flavanoids.”

A natural constituent of the papaya leaf is the Phytochemical flavanol and, of course, the protease papain.

The drugs in this case appear to mimic nature. Why not use the natural papaya leaf as a tea for reducing the inflammation from prostatisis?

One can only wonder about the other constituents in the natural papaya leaf that cause it to be naturally non/toxic even in large doses, used as an anti-inflammatory ethnomedicine in over ten countries, and shows an astounding list of effects on other diseases, including cancer.

Papaya leaf Composition:

Leaf Properties
Per 100 g, the leaves are reported to contain 74 calories, 77.5 g H2O 7.0 g.protein, 2.0g fat, 11.3 g total charbohydrate 1. 8 g fiber, 2.2 g ash, 344 mg Ca, 142mg P, 0.8 mg Fe, 16 mg Na, 652 mg K, 11,565 ug beta-carotene equivalent, 0.09mg thiamine, 0.48 mg riboflavin, 2.1 mg niacin, and 140 mg ascorbic acid, as well 136 mg vitamin E. Leaves contain the glycoside, carposide, and the alkaloid, carpaine. Fresh leaf latex contains 75% water, 4.5% caoutchouc-like substances,7% pectinous matter and salts, 0.44% malic acid, 5.3 papain, 2.4% fat, and 2.9% resin.

“Some of Papaya Leaf’s constituents include the fermenting agent myrosin, alkaloids, rutin, resin, tannins, carpaine, dehydrocarpaines, pseudocarpaine,flavonols, benzylglucosinolate, linalool, malic acid, methyl salicylate, another enzyme, chymopapain (latex and exudate), calcium, iron, magnesium, manganese,
phosphorus, potassium, zinc, beta-carotene, B-vitamins and vitamins A, C and E”.

The Julia Ruffin Project Promotes, Researches, and test-farms papaya leaf tea

Research 38 years ago: Papain Digests Liver Cancer Cells

Papain is one of the active cancer-fighting enzymes in the papaya leaf.

In 1976 the non-profit group, the Regina Elena Institute for Cancer Research sponsored a study on the effect of papain on the external wall of the liver cancer tumor cell. These malignant tumor cells show odd social behavior and unusual growth patterns. The cells on the external wall of the tumor were shown to be affected by papain in a way to slow growth. As quoted below from the study, Papain digests (gets rid of) the Navikaff (liver cancer) cells.

“…Papain digestion of Navikaff cells released cell surface gly capeptides that contained approximately 27% of the neura minidase-labile sialic acid…”

Effect of Neuraminidase and Papain Treatment on Lectin induced Agglutination of Novikoff Tumor Cells and Assay of Lectin Receptor Activity of the Glycopeptides Released from the Cell Surface by Papain

1Giovanni Neil
2 M. Christina Giuliano, Sylvia Capetillo, Ellen B. Gilliam, Douglas C. Hixson
3 and Earl F. Walborg, Jr.
4 Regina Elena Institute for Cancer Research,Viale Regina Elena N. 291, Rome,Italy [G. N., M. C. G.]; Department of Biochemistry.the University of Texas System Cancer Center,
M. D. Anderson Hospital and Tumor Institute [S. C., E. B. G., E. F. W.J;
and the University of Texas Health Science Center at Houston, Graduate School of Biomedical Sciences [D. C. H.], Houston,Texas77025