Papaya Leaf Tea: Oral Enzyme Therapy

Oral Enzyme Therapy combines various proteases (protein dissolving enzymes) in order to prevent disease, assist the body to fight various cancers, and lessen the negative effects of chemotherapy and radiation. The proteolytic enzymes papain and chymopapain are found naturally in the papaya leaf.

Memorial Sloan Cancer Center Site explains possible Mechanism of Action:
“PEs (proteolytic enzymes) are thought to exert immunomodulatory effects by causing increased release of reactive oxygen species by polymorphonuclear leukocytes (7) or by production of tumor necrosis factor-alpha and interleukins IL-6 and IL-1B that cause cytotoxic effects (1) (2). The antiangiogenic effects that papain exhibits in VEGF-activated human endothelial cells is concentration-dependent and likely due to interference with AKT, MEK1/2 and SAPK/JNK phosphorylation (15). Bromelain has been shown to lower the tumorigenic/metastatic capacities of sarcoma L-1 cells (3). It also inhibited glioma cell migration and invasion by affecting expression of integrins, necessary for cellular migration and invasion (5). In B16 murine melanoma models, PEs inhibited metastasis by reducing expression of CD44 and CD54 molecules (6).”

One example of a clinical trial that documented the lessened effect of radiation on cancer patients who took oral enzyme therapy is below:

Co-medication with hydrolytic enzymes in radiation therapy of uterine cervix: evidence of the reduction of acute side effects.

Dale PS1, Tamhankar CP, George D, Daftary GV.
Cancer Chemother Pharmacol. 2001 Jul;47 Suppl:S29-34.

“CONCLUSIONS: In patients with locally advanced cancer of the uterine cervix, oral enzyme therapy was found to be effective in significantly reducing radiation therapy-related side effects such as genitourinary symptoms, subcutaneous changes and reactions of the vaginal mucosa.”

In another clinical study, oral enzyme therapy was an effective complementary treatment for patients undergoing chemotherapy and radiation:

“…CONCLUSION: Complementary treatment of colorectal cancer patients with OE improves their quality of life by reducing both the signs and symptoms of the disease and the adverse reactions associated with adjuvant antineoplastic therapies. This epidemiological retrolective cohort analysis provides evidence that patients may also benefit by a prolongation of survival time. OE were generally well tolerated.”

PMID 11561874 [PubMed – indexed for MEDLINE]

Influence of a complementary treatment with oral enzymes on patients with colorectal cancers–an epidemiological retrolective cohort study.

Popiela T1, Kulig J, Hanisch J, Bock PR.
Cancer Chemother Pharmacol. 2001 Jul;47 Suppl:S55-63.

Papaya Leaf Tea as a natural oral enzyme therapy solution may contain a more complete set of necessary compounds to allow for absorption by the body. This theory is presented in part in the blog below:

Picture above; Mr Jacob Jeyasekaran
Of the Julia Ruffin Project

The Julia Ruffin Project promotes, researches, and test-farms papaya leaf tea.


Cancer Research Funds Papaya Leaf


Three Australian Cancer Research Foundations funded this preliminary study on papaya leaf that was published this summer 2014.

Funded by
Ramaciotti Foundation. Grant Number: ES2012/0104
Cancer Australia and Cure Cancer Australia Foundation. Grant Number: 1033781
National Health and Medical Research Council Career Development Fellowship

The result of the study:
“Saponins and total phenolic compounds were assessed for their antioxidant, free radical scavenging, ion-reducing capacity, and antipancreatic cancer activity. Optimal aqueous extraction conditions were 85 °C, 25 min. and a water-to-leaf ratio of 20:1 mL g−1. Ethanol extracts demonstrated higher antioxidant, free radical scavenging and ion-reducing capacity, as well as antipancreatic cancer activity. This study revealed that the PL contains numerous bioactive compounds, with significant anticancer activity warranting further studies on the isolation and characterisation of individual bioactive compounds from the PL.”

Antioxidant and anticancer capacity of saponin-enriched Carica papaya leaf extracts

Vuong, Q. V., Hirun, S., Chuen, T. L.K., Goldsmith, C. D., Murchie, S., Bowyer, M. C., Phillips, P. A. and Scarlett, C. J. (2014), Antioxidant and anticancer capacity of saponin-enriched Carica papaya leaf extracts. International Journal of Food Science & Technology. doi: 10.1111/ijfs.12618

Papaya leaf tea has been an Aboriginal medicine for cancer made most famous by the personal experiences of Harold Tietze in 1978, Papaya the Medicine Tree

#alternativemedicine #cancer

Pilot Study: White Cell Count Increases with Papaya Leaf Juice

This is not a new pilot study. But this is one that is worthy for promotion because cancer patients suffer from low white cell count. Papaya leaf is used as complementary treatment for cancers, and one reason is that it has shown to raise white cell count.

From, the following treatments may lower your white cell count:

“Breast cancer treatments that can lower your white blood cell count:

Abraxane (chemical name: albumin-bound or nab-paclitaxel)
Adriamycin (chemical name: doxorubicin)
carboplatin (brand name: Paraplatin)
Cytoxan (chemical name: cyclophosphamide)
Doxil (chemical name: doxorubicin)
Ellence (chemical name: epirubicin)
fluorouracil (also called 5-fluorouracil or 5-FU; brand name: Adrucil)
Gemzar (chemical name: gemcitabine)
Halaven (chemical name: eribulin)
Mitomycin (chemical name: mutamycin)
mitoxantrone (brand name: Novantrone)
Navelbine (chemical name: vinorelbine)
Taxol (chemical name: paclitaxel)
Taxotere (chemical name: docetaxel)
thiotepa (brand name: Thioplex)
radiation therapy
targeted therapy:
Avastin (chemical name: bevacizumab)
Herceptin (chemical name: trastuzumab)
Perjeta (chemical name: pertuzumab)
Tykerb (chemical name: lapatanib)”

Also the painful epidemic of chikungunya and Dengue Fever cause white cell count to be compromised.

The following pilot study shows that papaya leaf juice increased the white cell count of test subjects:

Salutary effects of carica papaya leaf extract in dengue fever patients – a pilot study
S Hettige1
Sri Lankan Family Physician, 2008, 29, 17-19

“From the [above] results it was evident that both the platelet counts and the total white cell counts had increased in all patients within 24 hours after administering papaya leaf juice. It is known that the platelet count drops in dengue patients after the first three days of fever and the gradually increases after the 7th day or drop further with derangement of other clotting factors to develop into dengue hemorrhagic state3. It was significant to observe that the platelet count increased in all 12 patients with two doses of papaya leaf juice and all patients recovered with no hospital admission….

This pilot study has shown the effects of papaya leaf juice in dengue patients of elevating the total white cell counts, platelet counts and recovery without hospital admission.
An adequate sample after obtaining ethical approval and advice from a statistician, doing clotting profiles before and after papaya intervention and using a control group would provide an answer to the question is papaya leaf extract effective in elevating the platelet count and clotting factors which are compromised in dengue fever.”


Dr S. Hettige

Egypt and South Africa: Papaya “aerial parts” Show Effect Against Breast Cancer in Lab

We are publishing lab studies done around the world that show the effect of papaya leaf on cancer to encourage cancer research organizations to direct resources toward clinical trials. Papaya leaf tea (cut papaya leaf herb) is inexpensive and available to market as a natural product.

South African and Egyptian scientists worked together at the end of 2013 to show effect of papaya plant “aerial parts” on breast cancer. The Julia Ruffin Project wants to acknowledge their work and success in proving effect in the lab. See the study details below.

Greener Journal of Pharmacy and Pharmacology Vol. 1 (1), pp. 001-005, October 2013
Research Article
Anticancer Activity of Carica papaya Extracts in vito and Phytochemical Analysis
Khaled N. Rashed1*, Gerda Fouche2
1National Research Centre, Pharmacognosy Department, Dokki, Giza, Egypt.
2Natural Product Chemistry Group, Council for Scientific and Industrial Research, PO Box 395, Pretoria 0001, South Africa.

The reported results show that petroleum extract of C. papaya aerial parts has significant anticancer effect on MCF7 (breast) cancer cells. Thus, C. papaya aerial parts could be helpful in cancer prevention and treatment. C. papaya could be a natural source of anticancer compounds with anti proliferative and/or apoptotic properties and as well, due to its anticancer pharmacological effect,
clinical trials are recommended to evaluate the beneficial effects of this plant in human models.”


The Julia Ruffin Project promotes, researches, and test-farms papaya leaf tea

Older posts related to breast cancer and papaya leaf:

#breastcancer Culinary Review of Papaya Leaf Tea

Review: Julia Ruffin Project Ltd. Papaya Leaf Tea
Herbal Tea, Julia Ruffin Project Limited, Papaya Tea

“To sum up the flavor: slightly vegetal, slightly botanical, slightly fruity, and a hint of medicinal.”
Vanessa’s Teaview: 8/10

“This young papaya leaf tea definitely ranks among the most unique and memorable teas that I have reviewed over the years. As the name suggests, this tea is made from the young leaves and stems of papaya plants.The Julia Ruffin website emphasizes that these leaves are hand picked from young plants, not large trees, and are dried in a solar-powered dehydrator. These leaves have been researched to contain numerous compounds that have wonderful medicinal benefits including fighting HIV, cancer, and malaria. The product website contains a wealth of information about the health benefits of this tea but I won’t get into the details in this review. Along with my sample of the young papaya leaf tea, I was also given a sample of cut papaya leaf herb to compare with it. I did a side-by-side brewing of these two teas to assess the difference. The first thing I will say is that it is VERY important to follow the brewing guidelines (which I at first could not find). I first used boiling water, and wow, that is a huge mistake. The tea is harsh, bitter, and pretty much undrinkable. But when the tea is prepared as recommended, by infusing the leaves in boiling water allowed to cool to 155 degrees F, it makes a world of difference. The Julia Ruffin website describes this tea as being similar to but sweeter than green tea. I would have to say that this is generally a pretty good description of these tea. I do notice that it has a bit of a medicinal flavor but it is not over-poweringor off-putting. The sweetness of this tea can best be characterized as a general fruitiness, although I really don’t think one could say that it tastes at all like the papaya fruit. To sum of the flavor: slightly vegetal, slightly botanical, slightly fruity, and a hint of medicinal.”

The Julia Ruffin Project promotes, researches, and test-farms papaya leaf tea. The Project does not sell papaya leaf tea, and only solicited a culinary review of new farming methods to further promote drinking of the tea. 


Set of Minerals in Papaya Leaf May Explain Medicinal Value

Scientists show a strong mineral set in the papaya leaf. The manganese specifically helps the body absorb enzymes. The powerful protease enzymes papain and chymopapain in the papaya leaf (which are considered cancer and inflammation fighters) may find a path to absorption through the manganese.

“…It has now been found that certain proteolytic enzymes are activated in the presence of ions of calcium, magnesium, manganese, cobalt or combinations thereof… Preferred for use as single activators are calcium and magnesium.”

-Activated enzyme compositions
US 3019171 A. 1957

International Journal of Scientific & Engineering Research, Volume 4, Issue 6, June-2013 1012

ISSN 2229-5518

Estimation of Minerals in Carica papaya L. Leaf found in Northern India by using ICP-OES Technique

Dinesh Kumar Sharma, Prof. B. Tiwari, Rabindra Kr. Singh, Sandeep Sahu, S. C. Mathur, R. M. Singh & G. N. Singh

The study on CP leaves done herewith has shown very rich minerals composition in green, yellow and brown leaves, which were collected from the plain as well as hill area of Northern India and CP leaves, can be seen as a potential source of useful drug, food & dietary supplement. The brown leaf can be used as anti-anaemic agent. It possesses immune-stimulants with anti-oxidant property. In the recent case study report, CP leaves extract controls dengue infection, has opens new gateway and raised eyebrows of many scientists. On the other hand, the presence of important anti-oxidants & vitamins may suppress various free radicals species induced during the viral infection. Particularly, the mineral composition may balance the mineral deficiency promoted by the virus and strengthen the immune cells against the dengue virus. The usefulness of these nine minerals obtained, like Ca, Mg, Mn, Na, K, Fe, Zn, Cu and Cr, which are found in rich quantity in CP leaves. The minerals are the elements that originate in the Earth and cannot be made by living organisms. Plants obtain minerals from the soil, and most of the minerals in our diets come directly from plants or indirectly from animal sources.

…Manganese (Mn) plays an important role in a number of physiologic processes as a constituent of multiple enzymes and an activator of other enzymes. A number of manganese- activated enzymes play important roles in the metabolism of carbohydrates, amino acids and cholesterol17.

…Manganese activates several enzyme systems and supports the utilization of vitamin C, E, choline, and other B-vitamins.

In Conclusion,
Therefore, papaya leaves due to its potent therapeutic properties can be formulated in herbal formulations as a medicine/dietary supplement and may be marketed as a nutraceutical product and as well as drug in curing the several diseases like Dengue fever, malaria etc.

The Julia Ruffin Project is a not for profit organization that promotes, researches, and grows papaya leaf tea

The purpose of this blog, sponsored by the Julia Ruffin Project, is to promote the value of the herb papaya leaf in its natural form taken as a tea or an extract.

Papaya Leaf May Make The New Antibiotic

The following study looks at the extract of papaya leaf and its antibacterial effect in the lab on gram-negative and gram-positive bacteria:

4.B.haemolytic streptococcus
5.Candida albicans

The extract is found to have broad-spectrum antibacterial activity and also used as analgesics and narcotics for pain relief. A report indicate that plant extracts are more active against Gram-positive bacteria than Gram-negative bacteria while that of the leaf extract of C. papaya was next to the most sensitivity with the Gram-negative bacteria especially Proteus mirabilis (Jigna and Sumitra, 2006). The activity of the extract is comparable to those of antibiotics. The demonstration of activity against the test bacteria provides scientific bases for the local usage of the plant in the treatment of various ailments. The fact that the extract is active against Gram-positive bacteria and Fungi tested may indicate a broad spectrum of activity. This observation is very significant because of the possibility of developing therapeutic substances that will be active against multidrug-resistant organisms.”