Lab Shows Anti-Pancreatic Cancer Effect of Papaya Leaf Tea

Focused on the Phytochemical saponin in the Carica Papaya Leaf, researchers tested the effect of papaya leaf tea as a 20:1 ratio of leaf to water brewed 25 minutes at 85 degrees C (185 F). The tea showed effect against cell lines with pancreatic cancer.

Antioxidant and anticancer capacity of saponin-enriched Carica papaya leaf extracts
Quan V. Vuong1,2, Sathira Hirun1,2, Tiffany L.K. Chuen1,2, Chloe D. Goldsmith1,2, Shane Murchie2, Michael C. Bowyer1,2, Phoebe A. Phillips3 andChristopher J. Scarlett1,2,4,*
Article first published online: 15 JUL 2014

DOI: 10.1111/ijfs.12618

© 2014 Institute of Food Science and Technology

http://onlinelibrary.wiley.com/doi/10.1111/ijfs.12618/abstract

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Papaya Leaf Powder will be the New “Matcha”

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Based on its unique natural phenols and phytochemicals, the papaya leaf stands out in Nature. Even as compared to Green Tea and its powdered form, (matcha or maccha), papaya leaf tea could be the new “matcha” in powdered form.

Green Tea boasts the natural phenol, catechin, (EGCG), which is shown to be effective in neutralizing free radicals. Matcha is generally considered for its super cancer-fighting in Japan due to this intense level of catechins. The availability of more catechins to your body with Matcha is based on the fact that this style of green tea preparation provides at least four times the effect of regular green tea brew because your body can absorb the whole leaf.

Determination of catechins in matcha green tea by micellar electrokinetic chromatography.
AuthorsWeiss DJ, et al. Show all Journal
J Chromatogr A. 2003 Sep 5;1011(1-2):
http://www.ncbi.nlm.nih.gov/m/pubmed/14518774/

Papaya leaf contains a phenolic content higher than any other part of the papaya plant. According to the Memorial-Sloan Cancer Center website, the phenolic compounds in the papaya leaf include: Dimethoxycoumarin, protocatechuic acid, p-coumaric acid, caffeic acid, chlorogenic acid, kaempferol and quercetin.
http://www.mskcc.org/cancer-care/herb/papaya-leaf

The cancer-fighting phytochemicals in the papaya leaf are gaining in reputation as compared to green tea. Papaya leaf has the complete set of cancer-fighting phytochemicals.

This invites us to consider not only its culinary appeal in powdered form, but also the increase in cancer fighting benefits of papaya leaf prepared as a Matcha. The thinking behind the Matcha form of green tea is that the whole leaf can be ingested, increasing its potency in your body.

Papaya leaf powder is available from most major herbal wholesalers.

http://omicsonline.org/open-access/proximate-analysis-antioxidant-and-antiproliferative-activities-of-different-parts-of-carica-papaya-2155-9600.1000267.pdf”

The Julia Ruffin Project researches, promotes, and grows papaya leaf tea.

Enzyme in Papaya Leaf, Papain, Inhibits Tumor Growth and Metastatis in Lab

Proteolytic Enzyme Therapy for cancerous tumors goes back to the success of Dr Beard in 1910 (Enzyme Therapy for Cancer). He retrieved the trypsin (a proteolytic enzyme) from young cows and injected it straight into the patient’s Tumor. This method showed success. Doctors who subsequently tried to mimic this procedure were discredited but they tried to retrieve trypsin from old cows, which by definition have less pancreatic enzymes due to their age. The theory of an “enzyme bank” that decreases as we age belongs to Dr Edward Howell, who proved this in a series of studies over years. (1945 +)

The enzyme in papaya leaves, papain, is a proteolytic enzyme that also seems to show a similar effect on tumors, as in this animal study below. Papain is a more potent proteolytic enzyme than our body’s trypsin.

Inhibition of tumor growth, invasion and metastasis in papain-immunized mice.

Authors
Bellelli A, Mattioni M, Rusconi V, Sezzi ML, Bellelli L.
Journal
Invasion Metastasis. 1990;10(3):142-69.

“The growth rate, invasion and metastasis of both the B16 melanoma and the Lewis lung carcinoma were inhibited in mice immunized with papain. These animals presented an increased mean survival time as compared to the tumor-bearing nonimmunized controls. Quantitative microscopy suggested that vasodilation and edema, associated with tumor invasion, are, at least partially, sustained by proteolytic enzymes, being strongly reduced when tumor cells were inoculated in papain-immunized mice.”

http://www.ncbi.nlm.nih.gov/m/pubmed/2139872/

Study Reveals Most Effective Anti-Cancer Papaya Leaf Tea Temperature

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The International Journal of Food Science and Technology published a study in July that claims the best anti-cancer temperature of Papaya Leaf Tea is 85C (185 degrees F) and cooked for 25 minutes with a water to leaf ratio of 20:1. The specific cancer under study was pancreatic cancer.
Antioxidant and anticancer capacity of saponin-enriched Carica papaya leaf extracts
Quan V. Vuong1,2, Sathira Hirun1,2, Tiffany L.K. Chuen1,2, Chloe D. Goldsmith1,2, Shane Murchie2, Michael C. Bowyer1,2, Phoebe A. Phillips3 andChristopher J. Scarlett1,2,4,*
http://onlinelibrary.wiley.com/doi/10.1111/ijfs.12618/abstract

Papaya Leaf Tea for Liver Disease

“Liver disease is the major cause of death worldwide. It ranks ninth in overall causes of death in the U.S. [1] and is the fifth ‘big killer’ in England & Wales. In India too, liver diseases are responsible for lakhs of deaths each year and is rather the only major cause of death still increasing year-on-year. Amongst the different types of liver diseases, alcoholic liver disease (ALD) is the leading cause of morbidity and mortality in the world. In an assessment by the WHO in 2005, 4% of the burden of the disease and 3.2% of all deaths globally were attributable to alcohol. The burden of alcohol-related disease is highest in the developed world, where it may account for as much as 9.2% of all disability-adjusted life years [2]. Even in the developing regions of the world, alcohol accounts for a major portion of global disease burden, and is projected to take on increasing importance in those regions over time [3]…. The available therapeutic interventions for liver diseases, which include drugs like steroids, anti-cytokines, colchicine or supplementation with calorie rich diet or a precursor of glutathione, S-adenosyl L-methionine (SAMe) have not been able to show convincing benefit in humans and also suffer from several side effects. Thus herbal medicines have an important role to play in the treatment of liver disorders considering their efficacy, safety and lesser side effects….The study thus concludes that the leaves of Carica papaya possess hepatoprotective activity, which may be partly due to its antioxidant effect. It also suggests that Carica papaya leaves are a promising candidate for the development of phytomedicine and can be used in herbal formulations alone or in combination with other hepatoprotective drugs (to provide a synergistic effect) for the treatment of liver ailments. Further, studies in humans are needed in this direction to prove its clinical utility.”

British Journal of Pharmaceutical Research 3(4): 648-661, 2013
SCIENCEDOMAIN international http://www.sciencedomain.org
Ameliorative Effect of Leaves of Carica papaya in Ethanol and Antitubercular Drug Induced Hepatotoxicity
Aashish Pandit1, Tarun Sachdeva1 and Pallavi Bafna1*
1Department of Pharmacology, Rayat Institute of Pharmacy, Railmajra, Punjab, India.
http://www.sciencedomain.org/download.php?f=1371531990-Pandit342013BJPR4517.pdf

Ina conclusion of a study on the leaf’s effect on hypoglycemia, the scientists conclude the study with this statement:

“…the leaf positively affected integrity and function of both liver and pancreas.”

Hypoglycemic effect of Carica papaya leaves in streptozotocin-induced diabetic rats
Isela Esther Juárez-Rojop1*, Juan C Díaz-Zagoya2, Jorge L Ble-Castillo1, Pedro H Miranda-Osorio1, Andrés E Castell-Rodríguez2, Carlos A Tovilla-Zárate4, Arturo Rodríguez-Hernández3, Hidemi Aguilar-Mariscal1, Teresa Ramón-Frías4 and Deysi Y Bermúdez-Ocaña4

Juárez-Rojop et al. BMC Complementary and Alternative Medicine 2012, 12:236 http://www.biomedcentral.com/1472-6882/12/236

Researchers advise Papaya Leaf for Immunity Disorder With Similarities to effect of Ebola

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Research by Nam Dang related to the effect of papaya leaf on the immune system may have advice for our ebola crisis. Best of all, papaya leaf is indigenous to these affected African countries and their ethno medicine includes the use of papaya leaf tea.

Follows is an article from 2003 that describes the effect of Ebola on DC cells and also the correlation to diseases such as Dengue H fever (which papaya leaf tea has shown effect). Then the leading research by Nam Dang and others which discusses the effect of carica papaya leaf tea extract and its related effect on the immune system.

Am J Pathol. Dec 2003; 163(6): 2347–2370.
doi: 10.1016/S0002-9440(10)63591-2
PMCID: PMC1892369
Pathogenesis of Ebola Hemorrhagic Fever in Cynomolgus Macaques

Evidence that Dendritic Cells Are Early and Sustained Targets of Infection

Thomas W. Geisbert,* Lisa E. Hensley,* Tom Larsen,* Howard A. Young,† Douglas S. Reed,* Joan B. Geisbert,* Dana P. Scott,* Elliott Kagan,‡ Peter B. Jahrling,* and Kelly J. Davis*
“…While the importance of monocytes/macrophages in EBOV pathogenesis have been well-documented, 28,30,41,43-44 few studies have addressed the importance of DC in EBOV pathogenesis; these cells also play important roles in initiation and regulation of the host immune response. DC are a family of professional antigen-presenting cells, derived from bone marrow, which have the ability to initiate and modulate cell-mediated immune responses. 45,46 Immature DC function as sentinels of the adaptive immune system; they are located in the peripheral tissues where they capture and process exogenous antigens and migrate to regional lymph nodes where they undergo maturation. A wide variety of stimuli, including infectious virus, bacterial antigens, or inflammatory cytokines, can trigger maturation of DC, which is characterized by phenotypic changes, including up-regulation of MHC and costimulatory molecules, and production of IL-12. Presentation of acquired antigen by mature DC leads to T-cell activation. 47,48 Monocytes circulating in the blood could be equally important in the DC response as circulating monocytes counter infection by crossing the endothelial barrier, infiltrating the focus of infection, and developing either into macrophages or DC.
Regarding the importance of EBOV predilection for DC in disease pathogenesis, we speculate that EBOV acts in a manner similar to other viruses that are known to disable the host immune response by attacking and manipulating the very cells that play the most critical roles in initiating the antiviral immune response. DC-tropic viruses such as HIV, 49,50 measles virus, 51-53 LCMV, 54 Dengue, 55 cytomegalovirus, 56 and HSV1 57 have evolved mechanisms to impair the function of DC, thereby enhancing their chance to escape immune surveillance…”
“…The current study demonstrates, for the first time, that DC are early and sustained cellular targets of EBOV in nonhuman primates; that lymphocyte apoptosis is a relatively early event in disease progression, and furthermore, it is the NK cell fraction that is likely lost through increased apoptosis early in the course of infection.”
“…While the importance of monocytes/macrophages in EBOV pathogenesis have been well-documented, 28,30,41,43-44 few studies have addressed the importance of DC in EBOV pathogenesis; these cells also play important roles in initiation and regulation of the host immune response. DC are a family of professional antigen-presenting cells, derived from bone marrow, which have the ability to initiate and modulate cell-mediated immune responses.”
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1892369/

Journal of Ethnopharmacology
journal homepage: http://www.elsevier.com/locate/jethpharm
Aqueous extract of Carica papaya leaves exhibits anti-tumor activity and immunomodulatory effects
Noriko Otsukia,1, Nam H. Dangb,1, Emi Kumagaia, Akira Kondoc, Satoshi Iwataa, Chikao Morimotoa,d,∗
a Division of Clinical Immunology, Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo, Japan b Division of Hematology/Oncology, The University of Florida, Gainesville, FL, USA
c Kondo Hospital, 1-6-25, Nishishinhama, Tokushima, Tokushima 770-8008, Japan
d Department of Rheumatology and Allergy, Research Hospital, The Institute of Medical Science, The University of Tokyo, Japan

“It is known that p40, a subunit of IL-12p70, is produced by antigen-presenting cells (APCs), such as monocytes or dendritic cells (DCs). It has also been shown that human IL-12p70 production from DCs is dependent on CD40-40L interactions, whereas p40 pro- duction is not (Cella et al., 1996). Based on these previous reports, it is conceivable that CP extract may modify not only activation of APCs, but also the interaction of T-APCs or T-B cells; namely, CP extract modifies both innate and acquired immunity.”

“…The family of monocyte-chemoattractant proteins, including CCL2 (MCP-1), CCL7 (MCP-3) and CCL8 (MCP-2), are considered to play important roles in the recruitment of monocytes, basophils, plasmacytoid dendritic cells and memory T lymphocytes to sites of inflammation. Their enhanced expression is correlated with vari- ous cytokines, such as IL-1􏰃, TNF-􏰁 and IFN-􏰀 (Viola and Luster, 2008). In addition, patients with high circulating level of CCL2 had significantly higher survival rate than those with low CCL2 pro- duction (Monti et al., 2003)…”

“…Our studies suggest that in addition to its anti- tumor effect, the fact that CP extract enhances production of Th1 type cytokines, such as IL-12, IFN-􏰀 and TNF-􏰁, raises the possibility that CP extract may contribute to the treatment of Th2-mediated allergic disorders, such as allergic rhinitis and bronchial asthma, or as an adjuvant of various vaccines by inducing a shift from Th2 to Th1 type immune response.”

“…Conclusion: Since Carica papaya leaf extract can mediate a Th1 type shift in human immune system, our results suggest that the CP leaf extract may potentially provide the means for the treatment and prevention of selected human diseases such as cancer, various allergic disorders, and may also serve as immunoadjuvant for vaccine therapy.”
http://www.researchgate.net/publication/40448909_Aqueous_extract_of_Carica_papaya_leaves_exhibits_anti-tumor_activity_and_immunomodulatory_effects