American Cancer Society has been Funding Research on Papaya Leaf Enzyme

American Cancer Society research on the enzyme papain in the papaya leaf:

IMG_1016.GIF

From 1954
https://papayaleaves.wordpress.com/2013/07/02/american-cancer-society-funded-research-sixty-years-ago-on-papaya-leaf-enzyme/

From 1962
The Carboxyl-Terminal Sequence of Papain
Journal of Biological Chemistry
Albert Light
http://www.jbc.org/content/237/8/2535.full.pdf

From 1964
Proc Natl Acad Sci U S A. Nov 1964; 52(5): 1276–1283.
PMCID: PMC300436
CURRENT STATUS OF THE STRUCTURE OF PAPAIN: THE LINEAR SEQUENCE, ACTIVE SULFHYDRYL GROUP, AND THE DISULFIDE BRIDGES*

Albert Light, Robin Frater,† J. R. Kimmel,‡ and Emil L. Smith

From 1969
“Digestion of tumor cell suspensions
with papain liberates a Sialoglycopeptide fraction from the cell surface…
Abercrombie and Ambrose (1) have proposed that alterations at the cell periphery contribute significantly to many of the manifestations of the malignant cell: invasiveness, liability to passive dissemination, and disorganization of structure…”

Isolation and Chemical Characterization of a Cell-Surface Sialoglycopeptide Fraction from Novikoff Ascites Cells
Earl F. Walborg, Jr., Roberta S. Lantz and Virginia P. Wray Cancer Research 1969;29:2034-2038.
http://cancerres.aacrjournals.org/content/29/11/2034.full.pdf

From 1970:
Immunochemistry
January 1970, Vol.7(1):1–4, IN1–IN2, 5–6, doi:10.1016/0019-2791(70)90025-X
The papain susceptibility of IgG myeloma proteins of different heavy chain subclasses ☆
J. Gergely
H.H. Fudenberg
Erna Van Loghem
http://www.sciencedirect.com/science/article/pii/001927917090025X

From 1985
Reversible Covalent Inhibition of Papain by a Peptide Nitrile. C NMR Evidence for a Thioimidate Ester Adduct.
Joseph B. Moon,la Robert S. Coleman,Ib and Robert P. Hanzlik*
Department of Medicinal Chemistry Received July 22, 1985
http://digitalunion.osu.edu/r2/summer05/page.151/Publications/5.pdf

From 1989:
http://books.google.com/books?id=gEgtL8EFQ9UC&pg=PA132&lpg=PA132&dq=american+cancer+society+papain+research&source=bl&ots=ee7yJTUhY1&sig=Lh04tb0CFJ_31x9vtuUjlKq2vEs&hl=en&sa=X&ei=vSP_U-b_JcbH8AGK5oHIAg&ved=0CCUQ6AEwADgK

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