Papaya Leaf Increases Platelet Count and Red Blood Cell Count in Sri Lankan Study

Sri Lankan study published this year in the Asian Journal of Tropical Biomedicine reached this conclusion:

Fresh C. papaya leaf extract significantly increased the platelet and RBC counts in the test group as compared to controls. Therefore, it is very important to identify those chemicals of C. papaya leaves as it can be recommended to be used as a medication to boost thrombopoiesis and erythropoiesis in humans and in animals.

Does Carica papaya leaf-extract increase the platelet count? An experimental study in a murine model
Sinhalagoda Lekamlage Chandi Asoka

Dharmarathna1, Susiji Wickramasinghe2*, Roshitha Nilmini Waduge3, Rajapakse Peramune Veddikkarage Jayanthe Rajapakse1, Senanayake Abeysinghe Mudiyanselage Kularatne4
1Department of Pathobiology, Faculty of Veterinary Medicine and Animal Science, University of Peradeniya, Sri Lanka 2Department of Parasitology, Faculty of Medicine, University of Peradeniya, Sri Lanka
3Department of Pathology, Faculty of Medicine, University of Peradeniya, Sri Lanka
4Department of Medicine, Faculty of Medicine, University of Peradeniya, Sri Lanka

Siti Zaleha Halim, Herbal Medicine Research Center, Institute for Medical Research, Jalan Pahang 50588, Kuala Lumpur, Malaysia.

This is a interesting study of the efferct of C. papaya leaves extract on the haematological and biochemical parameters in a murine model. The findings are impressive and useful for continuous study related to C. papaya. C. papaya leaf could be an alternative to treat dengue and malaria fever instead of prescription drugs.

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Read “Studies on Papaya Leaf Tea” for Details on how the Enzyme Papain in the Leaf affects Cancers

The Julia Ruffin Project researches, grows, and promotes papaya leaf tea. 

In promoting the tea it is important to explain the science behind the papaya leaf. This book focuses on the science of papain in the leaf and its effect on cancers. see

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Papaya Leaves Contain the Kit for Cancer: Alkaloid, Saponin, Tannin, Glycoside and Flavonoids

Carica Papaya leaves contain Alkaloid, Saponin, Tannin, Glycoside and Flavonoids according to a study PHYTOCHEMICAL ANALYSIS OF PAW-PAW (CARICA PAPAYA) LEAVES this year in India. The study was published by the International Journal of Life Sciences Biotechnology and Pharma Research.

Not only are these five the medicinal kit for cancer, but the five phytochemicals “…are characterized by multilateral pharmacological activity and broad spectrum of therapeutic actions.” – according to author Ikeyi Adachukwu P.











Current Research Shows Papaya Leaf Tea is Active Against Human Pathogens

Researchers just this year have published on the effect of papaya leaf tea (aqueous extract of papaya leaf) on human pathogens. Pakistani researcher Sherwani points out that we need to find a new bio active compound to combat infectious disease. In the study below his team showed effect of papaya leaf tea on seventeen human and plant pathogenic fungi. The study was published in the International Research Journal of Pharmacy 9/6/13.


What Papaya Leaf Tea Can Stimulate Macrophages To Do


Scientists have discovered that papaya leaf tea stimulates macrophages, the “big eaters” in your body. The function of macrophages is one key to battling auto-immune disease. The reason is that macrophages clean up waste in your body including poisons, pathogens, and, of course, cancer cells.

In photo above the macrophage is extending its arms to engulf two pathogens.

A very good description of the effect that macrophages have on auto-immune disease was published in Science Daily (below):

American Physiological Society (2010, August 27).

Macrophages: The ‘defense’ cells that help throughout the body. –ScienceDaily. Retrieved

Aug. 27, 2010 — The term “macrophage” conjures images of a hungry white blood cell gobbling invading bacteria. However, macrophages do much more than that: Not only do they act as antimicrobial warriors, they also play critical roles in immune regulation and wound-healing. They can respond to a variety of cellular signals and change their physiology in response to local cues.

“There has been a huge outpouring of research about host defense that has overshadowed the many diverse activities that these cells do all the time,” said Dr. Mosser. “We’d like to dispel the narrow notion that most people have that macrophages’ only role is defense, and expand it to include their role in homeostasis.”

Monocyte Differentiation
Macrophages exist in nearly all tissues and are produced when white blood cells called monocytes leave the blood and differentiate in a tissue-specific manner. The type of macrophage that results from monocyte differentiation depends on the type(s) of cytokines that these cells encounter. Cytokines are proteins produced by immune cells that can influence cell behavior and affect interactions between cells. For example, macrophages that battle microbial invaders arise in response to interferon-γ, a cytokine that is produced during a cellular immune response involving helper T-cells and the factors they produce. These macrophages are considered to be “classically activated.”
However, when monocytes differentiate in response to stimuli such as prostaglandins or glucocorticoids, the resulting macrophages will assume a “regulatory” phenotype. Alternately, wound-healing macrophages arise when monocytes differentiate in response to interleukin-4, a cytokine which is released during tissue injury…

Immune Regulation
Immune-regulating macrophages produce high levels of the cytokine interleukin-10, which helps suppress the body’s immune response. Suppressing an immune response may seem counter-intuitive, but in the later stages of immunity it comes in handy because it limits inflammation.

According to Dr. Mosser, immune-regulating macrophages may hold the key to developing treatments for autoimmune diseases such as multiple sclerosis or rheumatoid arthritis. The focus of new research is on reprogramming the macrophages to assume a regulatory phenotype and prevent autoimmunity, he said.
There is broad potential for exploiting different stages of macrophage activation, Dr. Mosser added. “It might be possible to manipulate macrophages to make better vaccines, prevent immunosuppression, or develop novel therapeutics that promote anti-inflammatory immune responses.”