Jamaican Nurses Experienced in Papaya Skin Therapy

According to a study by a reputable University in the Caribbean, more than 50% of Jamaican nurses interviewed were familiar with the effects of unripe papaya fruit for skin …”desloughing, granulation and healing and reduced odour in chronic skin ulcers…papaya was considered to be more effective than other topical applications in the treatment of chronic ulcers.”

The active enzymes in the unripe fruit are similar to those found in the young papaya leaf.

Authors of the study, Hewitt H, Whittle S, Lopez S, Bailey E, and Weaver S. noted that there is “…some difficulty in preparation of the fruit”.

The “Julia Ruffin Project” organized by Ruffin Trading Company of GA, USA will soon bring to market all-natural, easy to prepare products made in Jamaica from the young papaya leaf for topical use, tea, and medicinal fermented drink.

See http://www.papayaleavesforcancer.com

Reference the study quoted above:
Topical use of papaya in chronic skin ulcer therapy in Jamaica.

Hewitt H, Whittle S, Lopez S, Bailey E, Weaver S.
Journal West Indian Med J. 2000 Mar;49(1):32-3.

Department of Advanced Nursing Education, Faculty of Medical Sciences, University of the West Indies, Kingston, Jamaica.



Sri Lankan Scientists Show Impact of Papaya Leaf on Blood


News from the island that looks like a papaya;
Papaya leaf extract protects blood from hemolysis, and Sri Lankan scientists Ranasinghe P, Ranasinghe P, Abeysekera WP, Premakumara GA, Perera YS, Gurugama P, Gunatilake SB believe that papaya leaf extract can fight …”disease process causing destabilization of biological membranes.” This category should include invasive cancers.

See referenced University of Colombo study:

Asian Pacific Journal of Tropical Disease Publishes Study on Papaya Leaves: Suggest Anti-Cancer Drug


Journal published study that suggests that due to annonaceous acetogenins, papaya leaf biomass could be used for an anti-cancer drug.

Annonaceous acetogenins are similar to long-chain fatty acids. JL McLaughlin of Purdue University also has produced research claiming that it is the effect of the annonaceous acetogenins in the papaya leaf that have effect against cancer. He claims, [in the papaya leaf] “….powerful cytotoxicity, in vivo antitumor, pesticidal, antimalarial, anthelmintic, piscicidal, antiviral, and antimicrobial effects indicated a myriad of potentially useful applications. ”



Drugs With Papaya Leaf Enzyme Papain

The enzyme papain (and chymopapain), found in the papaya leaf, is an active ingredient in the following name brand drugs:

CCM Pharmaceuticals, Myanmar

The drug brand named Beazyme contains generic salt – Papain and is manufactured by Upha Corporation.Beazyme is mainly associated with symptoms and indications – The International Classification of Diseases (ICD)- A09AA – Enzyme preparations.

Generic Salts in Beazyme-Papain-Upha Corporation

Available types of drugs of Beazyme-Papain-Upha Corporation
Tablets; Oral; Papain 150,000 units

Medical categories of Beazyme-Papain-Upha Corporation
Human Drug
Skin and mucous membrane agents

Usage – Diseases of Beazyme-Papain-Upha Corporation
A09AA – Enzyme preparations

Manufacturers of Beazyme-Papain-Upha Corporation
Upha Corporation
CCM Pharmaceuticals

Bestozyme (Papain and Amylase, Alpha-)
Bio E, India

Bestozyme (200Ml)
Biological Evans Ltd
MRP Rs 60.00
Salts – Amylase (75mg) | Papain (60mg/5mL)

Pregnancy: B Lactation: L3 Lab: NA Food: NA
SIDE EFFECTS: Nausea, stomach upset, skin rash, acute toxicity.
DRUG INTERACTION: This drug should not be used with the following medications because very serious, possibly fatal interactions may occur: none known.
MECHANISM OF ACTION: Amylase is an enzyme that helps digest carbohydrates. It is produced in the pancreas and the glands that make saliva.
Pregnancy: D Lactation: L4 Lab: NA Food: NA
SIDE EFFECTS: Nausea, stomach upset, skin rash, acute toxicity.
DRUG INTERACTION: Tell your doctor of all prescription and nonprescription medication you may use. Do not start or stop any medicine without doctor or pharmacist approval.
MECHANISM OF ACTION: Papain contains substances called enzymes that help break down proteins.

Europharm, Hong Kong

Pharmaceutical active ingredients containing related brand and generic drugs, medications or other health care products: Papain
Eurolase available forms, composition, doses: Tablets, Film-Coated; Oral; Papain 100 mg
Eurolase destination | category: Human: Digestants Skin and mucous membrane agents Indications and usages, anatomical therapeutic chemical and diseases classification codes: A09AA – Enzyme preparations
Pharmaceutical companies, researchers, developers, manufacturers, distributors and suppliers: Europharm Laboratories

Rystan, United States
Used For: External Burns, Dermatalogic Cleansing, Wound healing

Papain Biopharmi
Biopharmi, Georgia

Papain Biopharmi – Indications: oedema, inflammation
Papain Biopharmi consists chiefly of a mixture of Papain Biopharmi and chymopapain, proteolytic enzymes that hydrolyse polypeptides, amides, and esters, especially at bonds involving basic amino acids, or leucine or glycine, yielding peptides of lower molecular weight. It is used for the inflamation of soft tissue. Preparations of papain, alone or combined with antibacterial agents and/or other substances, have been taken by mouth for their supposed anti-inflammatory properties, and it has also been used as an ingredient of various mixtures claimed to aid digestion. Papain Biopharmi is widely used as a meat tenderiser and in the clarification of beverages. Malignant neoplasms. Papain has been included in proteolytic enzyme preparations used in oncology to reduce the adverse effects of chemotherapy and radiotherapy. Although the number of clinical studies on which to judge efficacy is limited, a review1 of such studies suggested that systemic enzyme therapy might be beneficial. Clinical studies have used a preparation containing papain, trypsin, and chymotrypsin in a weight ratio of 5:2:2, and the beneficial effect seems to be based on its anti-inflammatory potential. Active ingredients: Papain

Papain Marching
Marching Pharmaceutical, Hong Kong
CAS registry number (Chemical Abstracts Service)

Therapeutic Category: Proteolytic enzyme

Chemical Name: A purified proteolytic substance derived from Carica papayaLinn?

Foreign Name
Papain (German)
Generic Names
Papainase (IS)
Papain (PH: USP 32)
Brand Names
Carident (Papain and Framycetine)
Jelfa, Poland
Sherfarma, Peru
Europharm, Hong Kong
Rystan, United States
Papain Marching
Marching Pharmaceutical, Hong Kong
Pfizer, Chile

Pfizer, Chile

Musculoskeletal: Non-Steroidal Anti-Inflammatory

Composition: Each tablet contains: standardized Papain (10000 U amount of enzyme activity Warner Chilcott) 5 mg.
Therapeutic Action: Anti-inflammatory.
Indications: Anti-inflammatory proteolytic enzyme useful in controlling bruising, swelling and edema caused by traumatic or inflammatory. Bruises, sprains, varicose ulcers and all clinical and exudation phlogosis including tissue. Cash to improve symptoms related to episiotomy.
Dosage: 2 tablets every 4 hours.
Side Effects: Occasionally nausea, vomiting, diarrhea, dizziness, pruritus, rash.
Contraindications: Do not administer simultaneously with anticoagulants, or in patients with bleeding disorders. Systemic infections and hypersensitivity to proteolytic enzymes extracted from Carica Papaya.
Precautions: In patients with renal or hepatic impairment. Not establishing safety during pregnancy.
Presentation: Cartons containing 15 and 30 tablets.

American Cancer Society Funded Research Sixty Years Ago on Papaya Leaf Enzyme


Back in 1954 when we only had typewriters, a grad student at the University of Utah named Joe R. Kimmel typed the results of his research on papain. Joe’s research on the predominant cancer-fighting enzyme in the papaya leaf (papain) was funded by the American Cancer Society. After hearing about this archive, the Director of the Julia Ruffin Project, Jill Nicole Gallo said, “my grandparents could have possibly lived longer if this research was made public”.

The Julia Ruffin Project is chartered to promote the health benefits of papaya leaf tea and focuses on its effect against cancer. Ms Gallo works a plan and a team that will make public these effects instead of burying the research of hardworking researchers in library archives. The Project is setting up to grow potent young leaves in Jamaica.

See http://www.papayaleavesforcancer.com

Our thanks to the dedicated team of library science at the University of Utah.