Papaya Leaf Tea Ideal Temp at 140F to 158F

20130629-094425.jpg

Two protein dissolving enzymes in the papaya leaf, papain and chymopapain, have been given credit for their effect against cancer.

According to the BIOZYM Corporation of Hamburg, Germany, papain operates at an ideal temperature of 140F to 158F (60C-70C). This is WHY papaya leaf is best taken in your body as a tea.

http://www.biozym.de/datasheets/papain.php

Chymopapain operates similar to papain but ideal temp is 98F, according to BRENDA, the comprehensive enzyme information system.

http://www.brenda-enzymes.org/php/result_flat.php4?ecno=3.4.22.6

20130629-095910.jpg

Advertisements

Papaya Leaf Tea is Four Times More Protective of Cells than Vitamin C

20130627-084053.jpg

New tests in the lab at Niger Delta University show that papaya leaf “tea” protects your red blood cells (erythrocytes) from free-radical damage (lipid peroxidation) better than ascorbic acid (manufactured vitamin C).

Reduction of hydrogen peroxide-induced erythrocyte damage by Carica papaya leaf extract.

Authors
Okoko T, et al. Show all Journal
Asian Pac J Trop Biomed. 2012 Jun;2(6):449-53. doi: 10.1016/S2221-1691(12)60074-4.

Affiliation
Biochemistry Programme, Department of Chemical Sciences, Niger Delta University, PMB 71, Wilberforce Island, Bayelsa State, Nigeria.

Abstract
OBJECTIVE: To investigate the in vitro antioxidant potential of Carica papaya (C. papaya) leaf extract and its effect on hydrogen peroxide-induced erythrocyte damage assessed by haemolysis and lipid peroxidation.

METHODS: Hydroxyl radical scavenging activities, hydrogen ion scavenging activity, metal chelating activity, and the ferrous ion reducing ability were assessed as antioxidant indices. In the other experiment, human erythrocytes were treated with hydrogen peroxide to induce erythrocyte damage. The extract (at various concentrations) was subsequently incubated with the erythrocytes and later analysed for haemolysis and lipid peroxidation as indices for erythrocyte damage.

RESULTS: Preliminary investigation of the extract showed that the leaf possessed significant antioxidant and free radical scavenging abilities using in vitro models in a concentration dependent manner (P<0.05). The extract also reduced hydrogen peroxide induced erythrocyte haemolysis and lipid peroxidation significantly when compared with ascorbic acid (P<0.05). The IC50 values were 7.33 mg/mL and 1.58 mg/mL for inhibition of haemolysis and lipid peroxidation, respectively. In all cases, ascorbic acid (the reference antioxidant) possessed higher activity than the extract.

CONCLUSIONS: The findings show that C. papaya leaves possess significant bioactive potential which is attributed to the phytochemicals which act in synergy. Thus, the leaves can be exploited for pharmaceutical and nutritional purposes.

http://www.ncbi.nlm.nih.gov/m/pubmed/23569948/

20130627-084406.jpg

Cytokines Talk Tea

20130625-104536.jpg

Dr Dang’s research on the effect of papaya leaf “tea” on cancer reviewed the now proven impact of T-1 type cytokines on communicating an immune response.

The article below explains how cytokines “talk tea”.

The immune-body cytokine network defines a social architecture of cell interactions
Ziv Frankenstein1,2, Uri Alon2 and Irun R Cohen*1

Abstract
Background: Three networks of intercellular communication can be associated with cytokine secretion; one limited to cells of the immune system (immune cells), one limited to parenchymal cells of organs and tissues (body cells), and one involving interactions between immune and body cells (immune-body interface). These cytokine connections determine the inflammatory response to injury and subsequent healing as well as the biologic consequences of the adaptive immune response to antigens. We informatically probed the cytokine database to uncover the underlying network architecture of the three networks.
Results: We now report that the three cytokine networks are among the densest of complex networks yet studied, and each features a characteristic profile of specific three-cell motifs. Some legitimate cytokine connections are shunned (anti-motifs). Certain immune cells can be paired by their input-output positions in a cytokine architecture tree of five tiers: macrophages (MΦ) and B cells (BC) comprise the first tier; the second tier is formed by T helper 1 (Th1) and T helper 2 (Th2) cells; the third tier includes dendritic cells (DC), mast cells (MAST), Natural Killer T cells (NK-T) and others; the fourth tier is formed by neutrophils (NEUT) and Natural Killer cells (NK); and the Cytotoxic T cell (CTL) stand alone as a fifth tier. The three-cell cytokine motif architecture of immune system cells places the immune system in a super-family that includes social networks and the World Wide Web. Body cells are less clearly stratified, although cells involved in wound healing and angiogenesis are most highly interconnected with immune cells.
Conclusion: Cytokine network architecture creates an innate cell-communication platform that organizes the biologic outcome of antigen recognition and inflammation. Informatics sheds new light on immune-body systems organization.”

http://www.biomedcentral.com/content/pdf/1745-6150-1-32.pdf

Papaya Leaf Tea Stimulates Macrophages

20130624-111330.jpg

Scientists have discovered that papaya leaf tea stimulates macrophages, the “big eaters” in your body.

Macrophages clean up waste in your body including poisons, pathogens, and, of course, cancer cells.

In photo above the macrophage is extending its arms to engulf two pathogens.

A very good description of macrophages was published in Science Daily (below):

American Physiological Society (2010, August 27).

Macrophages: The ‘defense’ cells that help throughout the body. –ScienceDaily. Retrieved

Aug. 27, 2010 — The term “macrophage” conjures images of a hungry white blood cell gobbling invading bacteria. However, macrophages do much more than that: Not only do they act as antimicrobial warriors, they also play critical roles in immune regulation and wound-healing. They can respond to a variety of cellular signals and change their physiology in response to local cues.

“There has been a huge outpouring of research about host defense that has overshadowed the many diverse activities that these cells do all the time,” said Dr. Mosser. “We’d like to dispel the narrow notion that most people have that macrophages’ only role is defense, and expand it to include their role in homeostasis.”

Monocyte Differentiation
Macrophages exist in nearly all tissues and are produced when white blood cells called monocytes leave the blood and differentiate in a tissue-specific manner. The type of macrophage that results from monocyte differentiation depends on the type(s) of cytokines that these cells encounter. Cytokines are proteins produced by immune cells that can influence cell behavior and affect interactions between cells. For example, macrophages that battle microbial invaders arise in response to interferon-γ, a cytokine that is produced during a cellular immune response involving helper T-cells and the factors they produce. These macrophages are considered to be “classically activated.”
However, when monocytes differentiate in response to stimuli such as prostaglandins or glucocorticoids, the resulting macrophages will assume a “regulatory” phenotype. Alternately, wound-healing macrophages arise when monocytes differentiate in response to interleukin-4, a cytokine which is released during tissue injury…

Immune Regulation
Immune-regulating macrophages produce high levels of the cytokine interleukin-10, which helps suppress the body’s immune response. Suppressing an immune response may seem counter-intuitive, but in the later stages of immunity it comes in handy because it limits inflammation.

According to Dr. Mosser, immune-regulating macrophages may hold the key to developing treatments for autoimmune diseases such as multiple sclerosis or rheumatoid arthritis. The focus of new research is on reprogramming the macrophages to assume a regulatory phenotype and prevent autoimmunity, he said.
There is broad potential for exploiting different stages of macrophage activation, Dr. Mosser added. “It might be possible to manipulate macrophages to make better vaccines, prevent immunosuppression, or develop novel therapeutics that promote anti-inflammatory immune responses.”

Solid Cancer Tumors

20130625-105813.jpg

Dr John Beard and Dr William Kelley proved in the lab that proteases kill cancer in solid tumor form.

Dr Nam Dang and Dr Otsuki concluded in the lab that papaya leaf tea (packed with proteases papain and chymopapain) kill cancer in solid tumor form as well.

-Aqueous extract of Carica papaya leaves exhibits anti-tumor activity and immunomodulatory effects.

AuthorsOtsuki N, et al. Show all Journal
J Ethnopharmacol. 2010 Feb 17;127(3):760-7. doi: 10.1016/j.jep.2009.11.024. Epub 2009 Dec 2.

Affiliation
Division of Clinical Immunology, Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.

An Alternative Perspective on Cancer

20130620-092709.jpg
An Alternative Perspective on Cancer and the Immune System:

What is Cancer and How Does It Attack the Body?

-“Immunition Report”, Frank M. Jordan Volume III, Number 5

“The most common cause of death in the U.S. is cancer, accounting currently for 1 in 2 mortalities… Billions spent in research have not dented death statistics.

Cancer is any of a group of more than 200 diseases with symptoms of unrestrained growth of cells in one of the body organs or tissues. The most common form of cancer is carcinoma which originates in the skin or in the glandular tissue such as the breast or prostate gland. Another form of cancer, sarcoma, affects connective and supportive tissue such as bone, muscle, cartilage and fat. Melanomas are more serious, often, but not always, manifested as skin cancers. Lymphomas affect the lymphatic system throughout the body, while leukemias are cancers of the blood-forming organs.

Did you know you probably get cancer up to six times per year, but your immune system when at peak recognizes, attacks and destroys the cancerous cells before potentially deadly growth and multiplication!

Prevention is promoted with proper lifestyle including nutrition, standard and so-called alternative treatments including nutritional supplements. Permissible treatments logically should be expanded to include these same factors proven safe and effective, in addition to the standards of surgery, chemotherapy and radiation to place the patient’s welfare as the number one priority instead of profits and exclusivity.

When not destroyed immediately by your immune system, the new cancer cells avoid the usual controls on growth and multiplication in normal cells. The growth begins when the genes controlling cell growth and multiplication called oncogenes are transformed by cancer-causing agents named carcinogens into cancer cells.

Normal cells can have a malignant change to become a cancer infested cell. These small groups of abnormal cancer cells divide more rapidly than the normal surrounding cells. The fast multiplication results in invasion and destruction of normal body cells. The abnormal cells usually show a lack of “differentiation,” meaning they no longer perform their unique roll as normal cells in maintaining good health. Cancerous cells act as uncontrollable parasites, consuming needed nutrients while contributing nothing except malnutrition.

If not killed and removed, these cancerous cells can then spread (metastasize) via the bloodstream and lymphatic system to other parts of the body from their original site and potentially be fatal if causing organs to fail.

Your immune response is critical to beating or controlling cancer because cancerous tumors develop and multiply when the white immune cells fail to recognize, respond and kill the cancerous cell invaders. If not at peak, the immune response often fails to respond timely when overwhelmed due to the massive number of corrupted cancer cells that have multiplied rapidly when undetected and unchecked.

What Do Cancer and Fetal Development Cells Have in Common?

Cancer cells are similar to fetal development cells called trophoblast that are responsible for the enormous growth from inception to day 55-60. The pancreas then starts working, secreting an enzyme called chymotrypsin. Trophoblast cells are negatively charged with a protein coating that repels white immune cells to prevent your immune system from destroying the developing child.

At the proper time, chymotrypsin destroys the protein coating, the abnormally fast growth ceases and normal baby development continues. Almost all cancer cells unfortunately exhibit this same protein coating with the negative charge that repels immune cells. If pancreatic enzyme production is impaired, as in diabetes or from fungal infections, cancer cells hide from the immune cells thus avoiding attack and removal. Supplemental proteolytic enzymes are believed to be beneficial nutritional supplements in cases of pancreatic enzyme production.

A Healthy Versus Suppressed Immune Response

When your immune response is in peak condition, it is better able to recognize the cancerous cells quickly and respond to kill the health invaders rapidly in most instances. A suppressed or impaired immune response exposes a body to both development and spread (metastasis) of too-often deadly cancer cells in the body.

We are often our own worst enemies instead of helping in our body war against cancer. Diets are poor, we exercise little, rest inadequately and stress too much. Our immune systems are suppressed with excessive free radicals (rogue molecules that damage cells similar to sparking wires) and nutrient delivery is impaired due to high toxicity and high acidity in the body.

Free radicals arrive in toxins entering our systems, including 4,000 legal food additives. Sugar is the food of cancer with a cancer cell having 92 sugar receptors compared to a normal cell with 4! Cancer could be increasing because we now eat an average of 150 lbs a year of sugar compared to only 5 lbs in 1904! Cancer also thrives in an acidic rather than balanced body. Keeping the pH balanced is essential to fighting cancer.

Add polluted air, most tap water; in addition to pathogens such as parasites, fungi, bacteria and viruses. Mix in heavy metals, particularly with dental work and toxic chemicals. Genetic factors damaging cellular DNA (together with caffeine) join immunological weaknesses in certain cancer types and cases.

Present Cancer Treatments – The Facts

The most common treatment in 50% of cancer cases is chemotherapy, but success unfortunately occurs in too few cases (2 to 25%), such as ovarian cancer in women, testicular cancer in men and Duke’s C, a form of colon cancer. Chemo too often shrinks tumor size but does not kill all the cancer cells while damaging other cells. How many cancer patients have heard the words, “We got it all but we want to do preventive chemotherapy to be sure!” Because chemotherapy ingredients often attempt to curtail rapidly multiplying cancer cells, other rapidly multiplying cells such as hair, nails and skin can also be negatively effected (hair loss, pallor, etc.) by multiple treatments.

Dr. Ralph Moss, author of Questioning Chemotherapy, explains most people confuse decreased tumor size with disappearance of disease. The association appears logical, but no known significant proof exists to support the connection. Statistics too often are skewed due to study drop-outs, age limitations on participants and even statistical definitions such as “cure” means an absence of cancer for a five year period from diagnosis.

Even more disturbing, chemotherapy and radiation are recognized carcinogens that can cause rather than cure cancer while increasing dangerous excess acidity which promotes cancer growth. Because of toxicity, chemotherapy and radiation are always spaced out time-wise between treatments, allowing the cancer cells often to multiply rapidly in the interim. Non-toxic alternative treatments do not require time spacing.

The Biopsy Dilemma in Metastasis

An irony can occur during a biopsy of an encapsulated tumor believed to be cancerous because of potential tumor perforation. If the biopsy procedure perforates a malignant tumor, cancer cells are released into the blood stream to metastasize that are otherwise contained. Sadly, a biopsy that can cause metastasis is often performed for legal reasons just before a surgery scheduled to prevent metastasis! If scheduled for cancer tumor surgery, ask for straight answers about the biopsy status and risk before the surgery.

Alternative therapies are often criticized for not being tested according to scientific standards, but many “accepted” treatments, including chemotherapy and radiation, have very limited success, but are both patentable and profitable. In fact, a “cure” is now defined as being alive 5 years after diagnosis – not cured, with present “cure rates” deceptively including non-life-threatening forms of cancer such as simple skin cancers.

This makes cure rates of 50% or more knowingly deceptive by the cancer and pharmaceutical industry due to deceptive statistic practices. This is a moral crime against the victims of cancer in giving knowingly unrealistic “cure” rates. Shouldn’t natural alternatives that have minimal toxic effects on other important functions of the body also be given research funds?

Why Don’t Pharmaceuticals Research and Promote Natural Cancer Treatments?

Alternative treatments are almost universally non-toxic, causing no harm to normal healthy cells in the body while the body is trying to recover from cancer. How can nutrition be an “alternative” treatment while injecting synthetic chemicals is mainstream? Hopefully the answer isn’t money, but the facts too often indicate otherwise. While surgery, chemotherapy and radiation target specific areas of the body, alternative treatments usually approach cancer as a holistic, or whole-body disease; while enhancing the immune response to better attack cancer cells throughout the body. The holistic approach makes sense as research indicates 60-75% of patients diagnosed with cancer have cancer already metastasized.

Why won’t giant pharmaceuticals market natural and alternative cancer treatments? The current system for a cancer drug to be approved by the FDA requires $700+ million dollars and years in research and approval time. Additionally, a natural cancer treatment is not patentable; a protection needed to assure exclusivity and substantial profits for a long-time period.

Being unpatentable makes the extensive time and huge expenditure uneconomic. Unless the system is changed, a natural form of treating cancer will almost certainly never be marketed by a major pharmaceutical. Medical schools also participate in patent profits. Profits – not people – all too often come first! Interrelationships between those regulating and those manufacturing have become more prevalent and disturbing in assessing the possible abuse of objectivity, although most in the regulatory agencies are well-intended and working within a system determined too often by politicians and contributors.

Doctors – Forced Denial by the Present Medical System

Patients many times are not aware that even if their health care provider wants to try a treatment forced to be classified as alternative, in most states the doctor is not legally allowed to prescribe or even recommend anything but surgery, chemotherapy and radiation due to the rigidity of antiquated Standards of Practice or Care.

Doctors often tell patients using alternative therapies to “keep on doing what you’re doing” to avoid personal licensing problems. Are physicians being taught nutrition and other alternative applications in Medical School in a positive and sufficient manner? The answer unfortunately is no, with little change anticipated. Why can’t we use the best of all health sciences with the patient – not the dollar – as our objective in application? The reality is until sick people vote and natural ingredients can produce billions of dollars for profits and contributions, the system priorities will remain with the wrong focus – to the detriment of the cancer victim.”

I choose to publish this perspective because it explains the science of why it is a good idea to add proteolytic enzymes (like chymopapain and papain in the papaya leaf) to your body because they contribute to dissolve the protein coating (similar to chymotrypsin) around cancer cells so that your body can destroy them.

20130620-091309.jpg

Nigerian Scientists Prove Papaya Leaf as a Malaria Prophylactic

20130619-083716.jpg

20130619-083759.jpg

Scientists Uhegbu, F. O., Elekwa, I., Ukoha, C. At Abia State University in Nigeria showed effect of papaya leaf “tea” on Malaria in the lab. Papaya leaf was compared to the effect of the malaria drug Maloxine.

Malaria has been documented as the number one killer of children in the world.

Reference their study:
English Title: Comparative efficacy of crude aqueous extract of Mangiferea indica, Carica papaya and sulphadoxine pyrimethamine on mice infested with malaria parasite in vivo. Personal Authors: Uhegbu, F. O., Elekwa, I., Ukoha, C.
Author Affiliation: Department of Biochemistry, Faculty of Biological and Physical Sciences, Abia State University, Uturu, Nigeria.
Document Title: Global Journal of Pure and Applied Sciences, 2005 (Vol. 11) (No. 3) 399-401
Abstract:
The comparative efficacy of sulfadoxine-pyrimethamine (Maloxine) and leaf extracts of Mangifera indica (mango) and Carica papaya (paw-paw) was investigated in Plasmodium berghei-infected mice. Maloxine had the highest efficacy, reducing the parasite count from an average count of 9.4?0.04 to 1.4?0.05 after six days of treatment. The paw-paw leaf extract reduced the malaria parasite count from an average of 9.2?0.06 to 2.6?0.06; while the mango leaf extract showed an average reduction from 9.8?0.01 to 3.2?0.03 after six days of treatment. However, a combination of the two leaf extracts (1:1) exhibited a higher antimalaria efficacy than the separate leaf extracts, reducing the parasite count from 9.4?0.031 to 2.0?0.15. The public health implications of these findings are discussed.
Publisher: Bachudo Science Co. Ltd.